DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3744 and CG11319

DIOPT Version :9

Sequence 1:	NP_001262935.1	Gene:	CG3744 / 42972	FlyBaseID:	FBgn0039240	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001285682.1	Gene:	CG11319 / 33923	FlyBaseID:	FBgn0031835	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	956	Identity:	206/956 - (21%)
Similarity:	339/956 - (35%)	Gaps:	309/956 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 PRLPWSPLLQQPI-------QSSGGSGGSGSASPYA-------------REYQLLQER---KRLS 373
            ||:....:..|.|       |.|.||...|....|.             |..::|...   |.||
  Fly    52 PRVKGQRIKLQDIVDGLFVPQHSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLS 116

  Fly   374 --TWGITSYELHKPSGKLVFPCFNDLYQCLDTGYNSGLLFPTQLRTCP---QWTALDPQICPQNS 433
              |:.|::.:.:....:.|...|...|....|.|:.......:||..|   :|..|.........
  Fly   117 PFTFTISADKRYLLLAQNVVKLFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAG 181

  Fly   434 DMIAYISDCDLFVTHTL-SGHEKRLTYTSTGRHSYVDDALSAGVPSYVMQEEFSRYQGFWWQPHS 497
            :.:.::...|::....: |....|:|      |..|...:..|:|.::.:||..         |:
  Fly   182 NALVWVQSYDIYYREEVRSASVHRIT------HDAVPGVVYNGIPDWLYEEEIL---------HA 231

  Fly   498 NDGIYR------IVYEEVDESEVSVYTF-------PSS--------------------------- 522
            |:.|:.      ::|...:::.|....|       ||:
  Fly   232 NNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGAGTGSPGAGGSNPH 296

  Fly   523 TAMHGRVDEYRFPRTGSPNAKSKLKLVQFVLNEALQVSEIAIKDL-PYSLLAVFSWLEYIVRVGW 586
            .:::..:...|:|:.|:.|....|::..  |.:.|:|.   |.|| |..::|  :...|.....|
  Fly   297 ASLYPEIRSLRYPKPGTQNPTVTLRVAD--LKDPLKVH---ITDLHPPQIIA--NEDHYFSSASW 354

  Fly   587 TPDAK--YVWVQGLDRKQQRLDVILIPLDNFCESYSSQVSTPTDSIGDHSWRSLYSRTITPL-QV 648
            ...:|  .||:    .:.|.:.|:.:     |::                          || |.
  Fly   355 VSHSKIAVVWL----NRPQNISVVSV-----CKA--------------------------PLFQC 384

  Fly   649 IYTER----SDSWINVHDMLHFLDLTETSVTFLWASEETGFRHLYLVTASLLLSQANGQPDPGSV 709
            |.|.|    ...|:            :|....|:|:..:    :|:..:.|         ..|..
  Fly   385 IETHRVSGDGRGWV------------DTVAVPLFAANAS----IYVAISPL---------RDGLF 424

  Fly   710 GAQPSFVDLSALQPRILNKVALTSGEWEVLARNLWVDKANKLVYFVGLRD-TPLEKHLYVVS--- 770
            |.....|.:...:.|:|   .||.|.:|| .|.|..|:.:..:||:|..: .|.::|||.||
  Fly   425 GYFRHIVHVDIDKNRVL---PLTHGPYEV-NRLLHWDQLDNWIYFLGTPERLPSQQHLYRVSALP 485

  Fly   771 ------LERPEHIRLLTEPGYSYLVE----------------FDD-------------------- 793
                  |..|:   .||.|..|...|                :||
  Fly   486 ARQGQALRSPD---CLTCPAVSQWSEGYDEGHTKSPPKLVTAWDDDWEDSEEAEAQPPQPALPVE 547

  Fly   794 ------------------------------QCKLMLLVYCNIQRLP-------------SCKVMR 815
                                          |.| .:|:.|....:|             |.|..|
  Fly   548 QQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAK-YVLIDCLGPVVPTSILYGLKSAAADSAKTKR 611

  Fly   816 VNQTCSNGGVNGIQISLVGYLHEGGKPEPQY---------------------CPQI--FSPQLPS 857
            .:.........|      |....|.:|:.|:                     .|||  |...:..
  Fly   612 HSTQQEEPPTEG------GDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAMPQIKTFPVMISG 670

  Fly   858 GDIVYAMVFKP---HNFELGVKYPTVLNVYGGPEVQTVN-------NTFKGKHQLRMHMLAAQGY 912
            |......::.|   ...|: .:|||:|:||.||..|.|.       ||:         :..::.|
  Fly   671 GYHAQVRLYLPPVLREDEI-TRYPTILHVYSGPGSQLVTDHWHVDWNTY---------LSGSKDY 725

  Fly   913 CVICIDSRGSRHRGKRFESHIRGRMGQVELTDQVDALRSLSDQLGYIDMDRVAIHGWSYGGYLSL 977
            .|:.||.|||..:|.:....:..|:|.||::||::....|.|.|.:||..|:.:.|||||||.:.
  Fly   726 IVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYLRDNLHFIDSRRMGVWGWSYGGYTAA 790

  Fly   978 MGLVQYPKIFKVAIAGAPVTNWEYYDTGYTERYMDMPQ--NNEAGYSAGSVLEYVNSFPEEDKRL 1040
            :.|.....||:..|:.:|||||:.||:.|.|||:..|.  :|..||....:.:||::.  .|::.
  Fly   791 LALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNL--RDRQF 853

  Fly  1041 LLIHGLIDENVHFCHTSRLISALNKANKPYEVHLFPEERHSLRNLE 1086
            ||:||..|:|||...:..|..:|......|:..::|:|.|||..::
  Fly   854 LLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSGVK 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_001262935.1	DPPIV_N	419..802	CDD:279298	88/510 (17%)
		DAP2	<838..1099	CDD:224423	87/284 (31%)
		Peptidase_S9	902..1101	CDD:278741	65/187 (35%)
CG11319	NP_001285682.1	DPPIV_N	123..504	CDD:279298	88/469 (19%)
		DAP2	<641..916	CDD:224423	84/271 (31%)
		Peptidase_S9	711..916	CDD:278741	67/200 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010