Protein Alignment CG3744 and Dpp8

DIOPT Version :10

• Sequence 1: NP_733056.3
• Gene: CG3744 / 42972
• FlyBaseID: FBgn0039240
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_001381020.1
• Gene: Dpp8 / 315758
• RGDID: 1310901
• Length: 892
• Species: Rattus norvegicus
• Alignment Length: 928
• Identity: 363/928 - (39%)
• Similarity: 510/928 - (54%)
• Gaps: 100/928 - (10%)

  Fly   200 ECDDCEEDEDDPVDNDGHIAAPTPNKSWAENKQVVQEIRKKMCNLSSMVPTNVQF--RHLSDG-- 260
            |..:|||...:..|............||::.|:::.:.||....:.:..|.:..|  |...||
  Rat    25 ETAECEEGNGESQDRPKLEPFYVERYSWSQLKKLLTDTRKYHGYMMAKAPHDFMFVKRADPDGPH 89

  Fly   261 RARCYFLGTPPQSWETTLLFADINLTQSEEQQLLVQRLEGIASDEWSPTMNAGSPTSSGHQPAFL 325
            ..|.|:|....::.|.||.:::|..|.:....|:
  Rat    90 SDRVYYLAMSGENRENTLFYSEIPKTINRAAVLM------------------------------- 123

  Fly   326 FNSLPRPRLPWSPLLQQPIQSSGGSGGSGSASPYAREYQLLQERKRLSTWGITSYELHKPSGKLV 390
                    |.|.|||.. .|::...|      .|:||.:||:||||:.|.||.:|:.|..||..:
  Rat   124 --------LSWKPLLDL-FQATLDYG------MYSREEELLRERKRIGTVGIAAYDYHPGSGTFL 173

  Fly   391 FPCFNDLYQCLD---TGYNSGLLFPTQLRT-CPQWTALDPQICPQNSDMIAYISDCDLFVTHTLS 451
            |...:.:|...|   .|:....|.|..:.| ||. ..:||::||.:.|.||:|...|:::::.::
  Rat   174 FQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPN-IRMDPKLCPADPDWIAFIHSNDIWISNLVT 237

  Fly   452 GHEKRLTYTSTGRHSYVDDALSAGVPSYVMQEEFSRYQGFWWQPH-----SNDGIYRIVYEEVDE 511
            ..|:||||......|..:|..||||.::|:||||.||.|:||.|.     |...|.||:|||.||
  Rat   238 REERRLTYVHNELASMEEDPRSAGVATFVLQEEFDRYSGYWWCPQAERTPSGGKILRILYEENDE 302

  Fly   512 SEVSVYTFPSSTAMHGRVDEYRFPRTGSPNAKSKLKLVQFVLNEALQVSEIAIKDL--PYSLLAV 574
            |||.:....|......|.|.:|:|:||:.|.|...|:.:.|::....:.::..|:|  |:.:|
  Rat   303 SEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIVVDAEGGIIDVIDKELVQPFEIL-- 365

  Fly   575 FSWLEYIVRVGWTPDAKYVWVQGLDRKQQRLDVILIPLDNFCESYSSQVSTPTDSIGDHSWRSLY 639
            |..:|||.|.||||:.||.|...|||.|..|.::||         |.::..|.:.......|.:.
  Rat   366 FEGVEYIARAGWTPEGKYAWSILLDRSQTHLQIVLI---------SPELFIPVEDDAMDRQRLIE 421

  Fly   640 S--RTITPLQVIYTERSDSWINVHDMLHFLDLT-ETSVTFLWASE-ETGFRHLYLVTASLLLSQ- 699
            |  .::||| :||.|.:|.|||:||:.|....| |..:.|::||| :|||||||.:|:.|..|:
  Rat   422 SVPDSVTPL-IIYEETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYKITSILKESKY 485

  Fly   700 ---ANGQPDPGSVGAQPSFVDLSALQPRILNKVALTSGEWEVLAR---NLWVDKANKLVYFVGLR 758
               :.|.|.|            |..:..|..::|:||||||||.|   |:|||:|.|||||.|.:
  Rat   486 KRSSGGLPAP------------SDFKCPIKEEIAITSGEWEVLGRHGSNIWVDEARKLVYFEGTK 538

  Fly   759 DTPLEKHLYVVSLERPEHIRLLTEPGYSYLVEFDDQCKLMLLVYCNIQRLPSCKVMRVNQTCSNG 823
            |:|||.||||.|...|..:..||:.|||:.......|...:..|.| |:.|.|..:....:..:.
  Rat   539 DSPLEHHLYVTSYANPGDVVRLTDRGYSHSCCLSRHCDFFISKYSN-QKSPHCVSLYKLSSPDDD 602

  Fly   824 GVNGIQISLVGYLHEGGKPEPQYC-PQIFSPQLPSGDIVYAMVFKPHNFELGVKYPTVLNVYGGP 887
            .|:..:......|...| |.|.|. |:|||.:..:|..:|.|::|||:.:.|.||||||.:||||
  Rat   603 PVHKTKEFWATILDSAG-PLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGP 666

  Fly   888 EVQTVNNTFKGKHQLRMHMLAAQGYCVICIDSRGSRHRGKRFESHIRGRMGQVELTDQVDALRSL 952
            :||.|||.|||....|::.||:.||.|:.||:|||.|||.:||...:.:|||:|:.|||:.|:.|
  Rat   667 QVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYL 731

  Fly   953 SDQLGYIDMDRVAIHGWSYGGYLSLMGLVQYPKIFKVAIAGAPVTNWEYYDTGYTERYMDMPQNN 1017
            :.|..:||:|||.|||||||||||||.|:|...||:|||||||||.|.:||||||||||..|..|
  Rat   732 ASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQN 796

  Fly  1018 EAGYSAGSVLEYVNSFPEEDKRLLLIHGLIDENVHFCHTSRLISALNKANKPYEVHLFPEERHSL 1082
            |.||..|||......||.|..||||:||.:||||||.|||.|:|.|.:|.|||::.::|:||||:
  Rat   797 EQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSI 861

  Fly  1083 RNLESNKNYETKLLSFLQ 1100
            |..||.::||..||.:||
  Rat   862 RVPESGEHYELHLLHYLQ 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_733056.3	DPPIV_N	419..802	CDD:395744	153/400 (38%)
		Peptidase_S9	902..1101	CDD:459761	115/199 (58%)
Dpp8	NP_001381020.1	Dpp_8_9_N	1..156	CDD:466112	40/176 (23%)
		DPPIV_N	169..589	CDD:395744	166/445 (37%)
		Peptidase_S9	681..885	CDD:459761	115/199 (58%)