DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3744 and Dpp4

DIOPT Version :9

Sequence 1:	NP_001262935.1	Gene:	CG3744 / 42972	FlyBaseID:	FBgn0039240	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_036921.2	Gene:	Dpp4 / 25253	RGDID:	2515	Length:	767	Species:	Rattus norvegicus

Alignment Length:	831	Identity:	186/831 - (22%)
Similarity:	334/831 - (40%)	Gaps:	200/831 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 GHQPAFLFNSLPRPRLPWSPLLQQPIQSSGGSGGSGSASP----YAREYQLLQERKRLSTWGITS 379
            |:...||.||              ..:..|.|....|.||    ...||..:::.:...|...:.
  Rat    82 GNSSIFLENS--------------TFEIFGDSISDYSVSPDRLFVLLEYNYVKQWRHSYTASYSI 132

  Fly   380 YELHKPSGKLVFPCFNDLYQCLDTGYNSGLLFPTQLRTCPQWTALDPQICPQNSDMIAYISDCDL 444
            |:|:|..                      |:...::....||....     |....:||:...|:
  Rat   133 YDLNKRQ----------------------LITEEKIPNNTQWITWS-----QEGHKLAYVWKNDI 170

  Fly   445 FVTHTLSGHEKRLTYTSTGRHSYVDDALSAGVPSYVMQEE-FSRYQGFWWQPHSNDGIYRIVYEE 508
            :|  .:..|......||||:    ::.:..|:..:|.:|| |..|...||.|   :|.: :.|.:
  Rat   171 YV--KIEPHLPSHRITSTGK----ENVIFNGINDWVYEEEIFGAYSALWWSP---NGTF-LAYAQ 225

  Fly   509 VDESEVSV--YTFPSSTAM-HGRVDEYRFPRTGSPNAKSKLKLVQFVLN-EALQVSEIAIKDLPY 569
            .:::.|.:  |:|.|..:: :.:.....:|:.|:.|...|.    |::| ::|..:...|   |.
  Rat   226 FNDTGVPLIEYSFYSDESLQYPKTVWIPYPKAGAVNPTVKF----FIVNTDSLSSTTTTI---PM 283

  Fly   570 SLLA---VFSWLEYIVRVGWTPDAKYVWVQGLDRKQQRLDVILIPLDNF-----CESYSSQVST- 625
            .:.|   |.:...|:..|.|..:.: :.:|.|.|.|....:.:...|..     |.:....:.|
  Rat   284 QITAPASVTTGDHYLCDVAWVSEDR-ISLQWLRRIQNYSVMAICDYDKTNLVWNCPTTQEHIETS 347

  Fly   626 PTDSIGDHSWRSLYSRTITPLQVIYTERSDSWINVHDMLHFLDLTETSVTFLWASEETGFRHLYL 690
            .|..:|          ...|.:..:|....|:..:                  .|::.|::|
  Rat   348 ATGWVG----------RFRPAEPHFTSDGSSFYKI------------------VSDKDGYKH--- 381

  Fly   691 VTASLLLSQANGQPDPGSVGAQPSFVDLSALQPRILNKVALTSGEWEVLARNLWVDKANKLVYFV 755
                :...|.:.:|:...     :|:               |.|.|||::...   ..:..:|::
  Rat   382 ----ICQFQKDRKPEQDC-----TFI---------------TKGAWEVISIEA---LTSDYLYYI 419

  Fly   756 G--LRDTPLEKHLYVVSL---------------ERPEH--IRLLTEPGYSYLVEFDDQCKLMLLV 801
            .  .::.|..::||.:.|               ||.::  :.|..|..|..|     .|:...|.
  Rat   420 SNEYKEMPGGRNLYKIQLTDHTNKKCLSCDLNPERCQYYSVSLSKEAKYYQL-----GCRGPGLP 479

  Fly   802 YCNIQRLPSCKVMRVNQTCSNGGVNGIQISLVGYLHEGGKPEPQYCPQIFSPQLPSG--DIV--- 861
            ...:.|....|.:||.:  .|..::                     ..:...|:||.  |.:
  Rat   480 LYTLHRSTDQKELRVLE--DNSALD---------------------KMLQDVQMPSKKLDFIVLN 521

  Fly   862 -----YAMVFKPHNFELGVKYPTVLNVYGGPEVQTVNNTFKGKHQLRMHMLAAQGYCVICIDSRG 921
                 |.|:..|| |:...|||.:::||.||..|..:..|  :.....::.:.:...|...|.||
  Rat   522 ETRFWYQMILPPH-FDKSKKYPLLIDVYAGPCSQKADAAF--RLNWATYLASTENIIVASFDGRG 583

  Fly   922 SRHRGKRFESHIRGRMGQVELTDQVDALRSLSDQLGYIDMDRVAIHGWSYGGYLSLMGLVQYPKI 986
            |.::|.:....|..|:|.:|:.||::|.|... ::|::|..:|||.|||||||::.|.|.....:
  Rat   584 SGYQGDKIMHAINKRLGTLEVEDQIEAARQFL-KMGFVDSKQVAIWGWSYGGYVTSMVLGSGSGV 647

  Fly   987 FKVAIAGAPVTNWEYYDTGYTERYMDM--PQNNEAGYSAGSVLEYVNSFPEEDKRLLLIHGLIDE 1049
            ||..||.|||:.|||||:.||||||.:  |::|...|...:|:....:|.:.:  .|||||..|:
  Rat   648 FKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVE--YLLIHGTADD 710

  Fly  1050 NVHFCHTSRLISALNKANKPYEVHLFPEERHSLRNLESNKNYETKLLSFLQ 1100
            ||||..::::..||..|...::...:.:|.|.:.:..::::..:.:..|||
  Rat   711 NVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQ 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_001262935.1	DPPIV_N	419..802	CDD:279298	77/415 (19%)
		DAP2	<838..1099	CDD:224423	84/272 (31%)
		Peptidase_S9	902..1101	CDD:278741	69/201 (34%)
Dpp4	NP_036921.2	DPPIV_rep	36..56	CDD:408582
		DPPIV_N	106..479	CDD:395744	85/480 (18%)
		Peptidase_S9	560..764	CDD:395257	70/207 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840