DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3744 and Dpp9

DIOPT Version :9

Sequence 1:	NP_001262935.1	Gene:	CG3744 / 42972	FlyBaseID:	FBgn0039240	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001347213.1	Gene:	Dpp9 / 224897	MGIID:	2443967	Length:	921	Species:	Mus musculus

Alignment Length:	905	Identity:	354/905 - (39%)
Similarity:	493/905 - (54%)	Gaps:	104/905 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 SWAENKQVVQEIRKKMCNLSSMVPTNVQFRHLSDGRA----RCYFLGTPPQSWETTLLFADINLT 286
            ||...:.::...||....:.|..|.:.||....|...    |.|:||.|..|.|.:||:::|...
Mouse    88 SWDGLRSIIHGSRKSSGLIVSKAPHDFQFVQKPDESGPHSHRLYYLGMPYGSRENSLLYSEIPKK 152

  Fly   287 QSEEQQLLVQRLEGIASDEWSPTMNAGSPTSSGHQPAFLFNSLPRPRLPWSPLLQQPIQSSGGSG 351
            ..:|..||                                       |.|..:|.. .|::...|
Mouse   153 VRKEALLL---------------------------------------LSWKQMLDH-FQATPHHG 177

  Fly   352 GSGSASPYAREYQLLQERKRLSTWGITSYELHKPSGKLVFPCFNDLYQCLDTGYNSGL---LFPT 413
                  .|:||.:||:|||||..:|||||:.|..||..:|...|.|:.|.|.|.|..:   :.|.
Mouse   178 ------VYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPL 236

  Fly   414 QLRTCPQWTALDPQICPQNSDMIAYISDCDLFVTHTLSGHEKRLTYTSTGRHSYVDDALSAGVPS 478
            :::|......:||:|||.:....::|::.||:|.:..:|.|:|||:...|....:|:..||||.:
Mouse   237 EIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGSAGVLDNPKSAGVAT 301

  Fly   479 YVMQEEFSRYQGFWWQP----HSNDGI--YRIVYEEVDESEVSVYTFPSSTAMHGRVDEYRFPRT 537
            :|:||||.|:.|.||.|    ..::|:  .||:|||||||||.|...||......:.|.||:|||
Mouse   302 FVIQEEFDRFTGCWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRT 366

  Fly   538 GSPNAKSKLKLVQFVLNEALQVSEIAIKDLPYSLLAVFSWLEYIVRVGWTPDAKYVWVQGLDRKQ 602
            ||.|.|..|||.:...:...::.....|:|.....::|..:|||.|.|||.|.||.|...|||.|
Mouse   367 GSKNPKIALKLAELQTDHQGKIVSSCEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQ 431

  Fly   603 QRLDVILIPLDNFCESYSSQVSTPTDSIGDHSWRSLYSRTITPLQVIYTERSDSWINVHDMLHFL 667
            |||.::|:|...|..:..|:......:      |:: .:.:.|. |||.|.::.||||||:.|..
Mouse   432 QRLQLVLLPPALFIPAVESEAQRQAAA------RAV-PKNVQPF-VIYEEVTNVWINVHDIFHPF 488

  Fly   668 DLTE--TSVTFLWASE-ETGFRHLYLVTASLLLSQANGQPDPGSVGAQPSFVDLSALQPRILNKV 729
            ...|  ....||.|:| :|||.|||.||..|.....:        ..:|........:..|..:|
Mouse   489 PQAEGQQDFCFLRANECKTGFCHLYRVTVELKTKDYD--------WTEPLSPTEDEFKCPIKEEV 545

  Fly   730 ALTSGEWEVLARN---LWVDKANKLVYFVGLRDTPLEKHLYVVSLERPEHIRLLTEPGYSYLVEF 791
            ||||||||||:|:   :||::..|||||.|.:|||||.||||||.|....|..||..|:|:....
Mouse   546 ALTSGEWEVLSRHGSKIWVNEQTKLVYFQGTKDTPLEHHLYVVSYESAGEIVRLTTLGFSHSCSM 610

  Fly   792 DDQCKLMLLVYCNIQRLPSCKVMRVNQTCSNGGVNGIQISLVGYLH----------EGGKPEPQY 846
            .....:.:..|.::...|...|.:::....:.            ||          |.....|.|
Mouse   611 SQSFDMFVSHYSSVSTPPCVHVYKLSGPDDDP------------LHKQPRFWASMMEAANCPPDY 663

  Fly   847 C-PQIFSPQLPSGDIVYAMVFKPHNFELGVKYPTVLNVYGGPEVQTVNNTFKGKHQLRMHMLAAQ 910
            . |:||.....:...:|.|::|||..:.|.|:||||.|||||:||.|||:|||...||::.||:.
Mouse   664 VPPEIFHFHTRADVQLYGMIYKPHTLQPGRKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASL 728

  Fly   911 GYCVICIDSRGSRHRGKRFESHIRGRMGQVELTDQVDALRSLSDQLGYIDMDRVAIHGWSYGGYL 975
            ||.|:.||.|||..||..||..::.:|||||:.|||:.|:.::::.|:||:.|||||||||||:|
Mouse   729 GYAVVVIDGRGSCQRGLHFEGALKNQMGQVEIEDQVEGLQYVAEKYGFIDLSRVAIHGWSYGGFL 793

  Fly   976 SLMGLVQYPKIFKVAIAGAPVTNWEYYDTGYTERYMDMPQNNEAGYSAGSVLEYVNSFPEEDKRL 1040
            |||||:..|::|||||||||||.|..|||||||||||:|:||:.||.||||..:|...|.|..||
Mouse   794 SLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQQGYEAGSVALHVEKLPNEPNRL 858

  Fly  1041 LLIHGLIDENVHFCHTSRLISALNKANKPYEVHLFPEERHSLRNLESNKNYETKLLSFLQ 1100
            |::||.:||||||.||:.|:|.|.:|.|||::.::|.||||:|..||.::||..||.|||
Mouse   859 LILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCRESGEHYEVTLLHFLQ 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_001262935.1	DPPIV_N	419..802	CDD:279298	149/394 (38%)
		DAP2	<838..1099	CDD:224423	143/261 (55%)
		Peptidase_S9	902..1101	CDD:278741	116/199 (58%)
Dpp9	NP_001347213.1	DPPIV_N	204..628	CDD:332444	161/439 (37%)
Dpp9	NP_001347213.1	Peptidase_S9	720..921	CDD:278741	116/199 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831433
Domainoid	1	1.000	258	1.000	Domainoid score	I1993
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16385
Inparanoid	1	1.050	595	1.000	Inparanoid score	I961
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55279
OrthoDB	1	1.010	-	-		D137965at2759
OrthoFinder	1	1.000	-	-		FOG0003791
OrthoInspector	1	1.000	-	-		otm43074
orthoMCL	1	0.900	-	-		OOG6_102236
Panther	1	1.100	-	-	LDO	PTHR11731
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4215
SonicParanoid	1	1.000	-	-		X2183
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940