DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3744 and apeh

DIOPT Version :9

Sequence 1:	NP_001262935.1	Gene:	CG3744 / 42972	FlyBaseID:	FBgn0039240	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_942570.3	Gene:	apeh / 100333019	ZFINID:	ZDB-GENE-030131-9870	Length:	746	Species:	Danio rerio

Alignment Length:	722	Identity:	152/722 - (21%)
Similarity:	266/722 - (36%)	Gaps:	168/722 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 HTLSGHEKR-------------LTYTSTGRHS--YVDDALSAGVPS-------YVMQEEFSRYQG 490
            :|..|.||:             |..|:..:|.  |.||.....|.|       |:.:::..:.:.
Zfish   124 NTTEGEEKQFLEIWHKNRKLKCLNLTTLNKHGKVYEDDQFGCLVWSHSETHLLYIAEKKRPKTES 188

  Fly   491 FWWQ-------PHSNDGIYRIVYEEVDESEVSVYTFPSSTAMHGRVDEYRFPRTGSPNAKSKLKL 548
            ::.|       |...:.|      :.|:.|.:|   |.        .::.:......|..||...
Zfish   189 YFQQGPETSLTPDEEEPI------KTDKKEETV---PG--------HQFEYYEDWGENLVSKSSP 236

  Fly   549 VQFVLNEALQVSEIAIKDLPYSLLAVFS-----WLEY---IVRVGWTPDAKYVWVQGLDRKQQRL 605
            |..||:  ::.|.|::.:   .:.|..|     |...   ::.|||..:...:.::....::..|
Zfish   237 VLCVLD--IEGSNISVLE---GIPAAISPGQAFWAPADTGLLFVGWWHEPFRLGLKSCGNRRSSL 296

  Fly   606 DVILIPLDNFCESYSSQVSTPTDSIGDHSWRSLYSRTITP--LQVIYTER--SDSWINVHDMLHF 666
            ..:.: ....|:..||      |||      |:.|..::|  .:::|.|.  |.|.:..|.:
Zfish   297 FYVDL-ASGKCDQLSS------DSI------SVCSPRLSPDHCRIVYLESGVSCSHLQCHRL--- 345

  Fly   667 LDLTETSVTFLWASEETGFRHLYLVTASLLLSQANGQPDPGSVGAQPSFVDLSALQPRILNKVAL 731
                   ..|.|.:::|          |:::.......|.|..|.. ||:    |.||
Zfish   346 -------CVFDWYTKQT----------SVVVDVVQRARDDGFTGIY-SFL----LSPR------- 381

  Fly   732 TSGEWEVLARNLWVDKANKLVYFVGLRDTPLEKHLYVVSLERPEHIRLLT---EPGYSYLVEFDD 793
                       .|...:.::::....|.   .|.|:||.....|..||.:   |..::.|....|
Zfish   382 -----------CWSADSERVLFCSAQRS---RKELFVVDTSSREITRLTSQSQEGSWNLLNIHRD 432

  Fly   794 QCKLMLLVYCNIQRLPSCKVMRVNQTCSNGGVNGIQ-ISLVGYLHEGGKPEPQYCPQI--FSP-- 853
                :::|.|:....|  ..:||......|..:.|. ::|     |..:|:.....|.  |||
Zfish   433 ----LMVVSCSSPNSP--PDLRVGFLPGKGSESKISWVTL-----EESQPQSDISWQTLNFSPPP 486

  Fly   854 -----QLPSGDIVYAMVFKPHNFELGVKYPTVLNVYGGPEVQTVNNTFKGKHQLRMHMLAAQGYC 913
                 |.|..|. .|::.||.:.....|.|.::..:|||....|:...     |...:|...|:.
Zfish   487 EQDNTQYPGLDF-DALLLKPKDTPADGKLPLIVMPHGGPHSVLVSEWI-----LSTAVLCKMGFS 545

  Fly   914 VICIDSRGSRHRGKRFESHIRGRMGQVELTDQVDALRSLSDQLGYIDMDRVAIHGWSYGGYLSLM 978
            |:.::.|||...|:.....:.|..|..::.|...|:.|:..|.|: |..:||:.|.|:||:|:..
Zfish   546 VLLVNYRGSLGFGQDNVFSLPGNCGTQDVKDVQFAVDSVLKQGGF-DEQKVAVIGGSHGGFLACH 609

  Fly   979 GLVQYPKIFKVAIAGAPVTN------------WEYYDTGYTERYMDMPQNNEAGYSAGSVLEYVN 1031
            .:.|||..:|..:|..||||            |...:.|:.  |....|...|......:...:.
Zfish   610 LIGQYPGFYKACVARNPVTNLASMVCCTDIPDWCIVEAGFD--YKPDIQLEPAILEQMLIKSPIK 672

  Fly  1032 SFPEEDKRLLLIHGLIDENVHFCHTSRLISALNKANKPYEVHLFPEERHSLRNLESNKN-YETKL 1095
            ...:....:||:.|..|:.|..........||.....|..|..:|...|||..:::..: :....
Zfish   673 HVAKVKTPVLLMLGEGDKRVPNKQGIEYYKALKSLQVPVRVLWYPGNNHSLSKVDAESDGFMNGA 737

  Fly  1096 LSFLQNL 1102
            |..:|:|
Zfish   738 LWMIQHL 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_001262935.1	DPPIV_N	419..802	CDD:279298	73/397 (18%)
		DAP2	<838..1099	CDD:224423	69/282 (24%)
		Peptidase_S9	902..1101	CDD:278741	51/211 (24%)
apeh	NP_942570.3	DAP2	197..728	CDD:224423	135/631 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574444
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840