DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3744 and dpp4

DIOPT Version :9

Sequence 1:	NP_001262935.1	Gene:	CG3744 / 42972	FlyBaseID:	FBgn0039240	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001154809.1	Gene:	dpp4 / 100301982	ZFINID:	ZDB-GENE-081104-277	Length:	742	Species:	Danio rerio

Alignment Length:	848	Identity:	209/848 - (24%)
Similarity:	340/848 - (40%)	Gaps:	216/848 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 IASDEWSPTMNAGSPTSSGHQPAFLFNSLPRPRLPWSPLLQQPIQSSGGSGGSGSASPYAR---- 361
            ::.||:......||        .||||:                 ::|......:...:||
Zfish    59 VSDDEYFHKTGEGS--------VFLFNA-----------------TTGNGNEFVNQQIFARVAAF 98

  Fly   362 EYQLLQERKRLSTWGITSYELHKPSGKLVFPCFNDLYQCLDTGYNSGLLFPTQLRTCPQWTALDP 426
            :|.:..:||.:..  :::|.      ||....:...|...|.....  ...|.:....|:.|..|
Zfish    99 DYLVSADRKYVCF--LSNYT------KLWRHTYTASYSIYDLEKRD--FINTDIPHDVQYLAWSP 153

  Fly   427 QICPQNSDMIAYISDCDLFVTHTLSGHEKRLTYTSTGRHSYVDDALSAGVPSYVMQEE-FSRYQG 490
                 ....:|::...:::|..|.:...|::  |:.|.|:.:.:    |||.:|.:|| ||....
Zfish   154 -----TGHKLAFVWKYNVYVKETPNSAFKQV--TTNGAHNLILN----GVPDWVYEEEMFSTNSA 207

  Fly   491 FWWQPHSNDGIYRIVYEEVDESEVS--VYT------FPSSTAMHGRVDEYRFPRTGSPNAKSKLK 547
            .||.|:..    .:.|.|.::|||.  .||      :|.:..:       .:|:.|:||...||.
Zfish   208 LWWSPNGR----FVAYAEFNDSEVHNIEYTWFGEGQYPETVFV-------PYPKAGTPNPTVKLF 261

  Fly   548 LVQFVLNEALQVSEIAIKDLPYSLLAVFSWLEYIVRVGWTPDAKYVWVQGLDRKQQRLDVILIPL 612
            :.....|...|||      :|..   |.:...|:..|.|..|.: :.||...|.|..  |:|...
Zfish   262 VFDTNTNTIKQVS------VPSD---VGAGEHYLSTVTWASDHR-IAVQWQKRTQNY--VVLETY 314

  Fly   613 D----NFCESYSSQVSTPTDSIGDHSWRSLYSRTITPLQVIYTERSDSWINVHDMLHFLDLTETS 673
            |    |:.|...||:.  |.|.|   |...:|    |.:.::  |.|.               .|
Zfish   315 DFNDGNWTEGSLSQII--TSSTG---WVGRFS----PDEPVF--RPDG---------------NS 353

  Fly   674 VTFLWASEETGFRHL-YLVTASLLLSQANGQPDPGSVGAQPSFVDLSALQPRILNKVALTSGEWE 737
            ..::.:::|. |:|| |.                  :|.|               ::.||.|:||
Zfish   354 CYYILSNDER-FKHLAYF------------------IGTQ---------------RIFLTRGKWE 384

  Fly   738 VLARNLWVDKANKLVYFVG--LRDTPLEKHLYVVSLERPEHIRLLTEPGYSYLVEFDDQCKLMLL 800
            |::   .:...|..:|||.  ..::|.::::|.:::....|              .|.:|   |.
Zfish   385 VIS---ILKVTNNALYFVSNEHNESPGQRNVYKITINGASH--------------SDREC---LT 429

  Fly   801 VYCNIQRLPSCKVMRVN---------QTCSNGGV-----------------NGIQISLVGYLHEG 839
            ...|..|   ||.....         .:||..|:                 |.:   |...|.|.
Zfish   430 CTLNADR---CKYNSATFSTEGSYYLMSCSGPGLPLYTLRNSQAELRVLENNSV---LEHKLQEI 488

  Fly   840 GKPEPQYCPQIFSPQLPSG--DIVYAMVFKPHNFELGVKYPTVLNVYGGPEVQTVNNTFKGKHQL 902
            ..|...|      .:|..|  |:.|.|:..| .|:...|||.:::||.||..|  .:.|:.:...
Zfish   489 AMPSNMY------GKLKIGEFDLWYQMILPP-RFDKSKKYPLLIDVYAGPCSQ--KSDFRFRVGW 544

  Fly   903 RMHMLAAQGYCVICIDSRGSRHRGKRFESHIRGRMGQVELTDQVDALRSLSDQLGYIDMDRVAIH 967
            ..::.:.:...|...|.|||.::|.:....:..|:|..|:.||:.|.|...| :|:||..|:||.
Zfish   545 STYLASTERVIVASFDGRGSGYQGDQIMHALYKRLGTYEVEDQITAARQFID-MGFIDKSRIAIW 608

  Fly   968 GWSYGGYLSLMGLVQYPKIFKVAIAGAPVTNWEYYDTGYTERYMDMPQNNEAGYSAGSVLEYVNS 1032
            |||||||::.|.|.....:||..:|.|||:.|||||:.||||||..|..|:|.|...:|.....|
Zfish   609 GWSYGGYVTSMVLGAGSGVFKCGMAVAPVSKWEYYDSIYTERYMLTPAENQAFYDNSTVTGRAKS 673

  Fly  1033 FPEEDKRLLLIHGLIDENVHFCHTSRLISALNKANKPYEVHLFPEERHSLRNLESNKNYETKLLS 1097
            |  :..:.||:||..|:||||...:::..||......::...:.:|.|||.. .:|::..|.:..
Zfish   674 F--KSVQYLLVHGTADDNVHFQQAAQISKALVDEQVDFDTMWYTDEDHSLGG-SANQHVYTHMTH 735

  Fly  1098 FLQ 1100
            ||:
Zfish   736 FLK 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_001262935.1	DPPIV_N	419..802	CDD:279298	88/398 (22%)
		DAP2	<838..1099	CDD:224423	89/262 (34%)
		Peptidase_S9	902..1101	CDD:278741	72/199 (36%)
dpp4	NP_001154809.1	DPPIV_N	103..461	CDD:279298	103/484 (21%)
		FrsA	509..733	CDD:223999	82/230 (36%)
		Peptidase_S9	540..741	CDD:278741	72/203 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574437
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840