Protein Alignment CycB3 and CCNB1

DIOPT Version :9

• Sequence 1: NP_001262934.1
• Gene: CycB3 / 42971
• FlyBaseID: FBgn0015625
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_114172.1
• Gene: CCNB1 / 891
• HGNCID: 1579
• Length: 433
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 147/551 - (26%)
• Similarity: 228/551 - (41%)
• Gaps: 163/551 - (29%)

  Fly    45 TGNIDPNVENMQTRAK------RKADHSPIKNDK---IKRSALGNLTNNVKIMTLHPAQDEEQSG 100
            |.|...|.||   :||      ::...:|....|   ..|:|||::.|.|
Human     6 TRNSKINAEN---KAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKV--------------- 52

  Fly   101 VGKKPTAQQLQALMDAKKQENLSVNVFGASKMTTRASSKVEDSVENCHKVLDKLEEALARPKPRP 165
                  ::||||.|..||:...|..                      .||:||     ..|||..
Human    53 ------SEQLQAKMPMKKEAKPSAT----------------------GKVIDK-----KLPKPLE 84

  Fly   166 KAVPAAKKTVLGEVQLPAMPNPMQIPVLLPPTHNLAAPQ-VAAVKPVRRISNDFNKTEDSLYMSA 229
            |.                   ||.:||  |.:..:..|: ....:||:         |:.|
Human    85 KV-------------------PMLVPV--PVSEPVPEPEPEPEPEPVK---------EEKL---- 115

  Fly   230 LEDVSSCDSMRLSGNFEAARRRSAKLQQKTEQQPQPLLLTLPETAPSQVVPIPPVPEE------- 287
                                            .|:|:|:.....:|.:.....|..|:
Human   116 --------------------------------SPEPILVDTASPSPMETSGCAPAEEDLCQAFSD 148

  Fly   288 ----VEDFDRKNWDDPFQVSHYAMDIFNYLKVREAEFPIADYMPRQI---HLTTWMRTLLVDWMV 345
                |.|.|.::..||...|.|..||:.||:..|.|..:   .|:.:   .:|..||.:|:||:|
Human   149 VILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAV---RPKYLLGREVTGNMRAILIDWLV 210

  Fly   346 EVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIACKYDERQPPLIEDFLYICDG 410
            :||..|.|..||:|:.|.|:|.::....:.|:.|||:|..|.|||.||:|..||.|.||.::.|.
Human   211 QVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDN 275

  Fly   411 AYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTLTLARYILELSLMDYANISFS 475
            .|...::.:||.:.||.:.:.||.||...||||.::..:|.:...|||:|::||:::||..:.|.
Human   276 TYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFP 340

  Fly   476 DSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYTGYQ-------LADFAEIVTALNAGLHRKPR 533
            .||:|:.|..:||::      ||...||.||.:|..|.       :...|:.|..:|.||.:.
Human   341 PSQIAAGAFCLALKI------LDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKH-- 397

  Fly   534 ATIKTIRNKYSHKIFHEVAKVPLLTNQELFQ 564
               .|::|||:.....:::.:|.| |..|.|
Human   398 ---MTVKNKYATSKHAKISTLPQL-NSALVQ 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	47/127 (37%)
		Cyclin_C	435..555	CDD:281044	39/126 (31%)
CCNB1	NP_114172.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..47		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..116		6/67 (9%)
		Interaction with CDK2	169..177		3/7 (43%)
		Cyclin_N	173..298	CDD:278560	47/127 (37%)
		Interaction with CDK2	258..261		1/2 (50%)
		Cyclin_C	300..418	CDD:281044	40/128 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D475911at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850