DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB3 and CLB5

DIOPT Version :9

Sequence 1:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_015445.1	Gene:	CLB5 / 856237	SGDID:	S000006324	Length:	435	Species:	Saccharomyces cerevisiae

Alignment Length:	456	Identity:	112/456 - (24%)
Similarity:	194/456 - (42%)	Gaps:	119/456 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 NLSV--NVFGASKMTTRASSKVEDSVENCHKVLDKLEEALARPKPRPKAVPAAKKTVLGEVQLPA 183
            ||.:  |....||..:.:..:|:||                  ||| :|:          ..:|.
Yeast    29 NLKILQNKRALSKNDSSSKQQVQDS------------------KPR-RAL----------TDVPV 64

  Fly   184 MPNPMQIPVLLPPTHNLAAPQVAA-------VKPV------RRISNDFNKTEDSLYMSALEDVSS 235
            ..||      |.....:.|...||       ::|:      |:|.||
Yeast    65 NNNP------LSQNKRIVAGSKAAKVRREENIRPIVSAVQKRQIYND------------------ 105

  Fly   236 CDSMRLSGNFEAARRRSAKLQQKTEQQPQPLLLTLPETAPSQV-----VPIPPVPEEV--EDFDR 293
                          |.:|:.:::.|::.:      .:.|.|.|     :....|.|.|  :|.|.
Yeast   106 --------------RTAAEQEEEEEEEGE------DDDAASIVNKKRRIDAEGVSEIVGWQDLDY 150

  Fly   294 KNWDDPFQVSHYAMDIFNYLKVREAE-FPIADYM---PRQIHLTTWMRTLLVDWMVEVQETFELN 354
            ...||...|:.|:.:||.:|..||.| .|..:|:   ..:.:|...|||:||||:|||.|.|:..
Yeast   151 VEKDDTAMVAEYSAEIFAFLYRRELETLPSHNYLLDKTSKYYLRPSMRTILVDWLVEVHEKFQCY 215

  Fly   355 HETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIACKYDERQPPLIEDFLYICDGAYNHDELVR 419
            .|||:|::.::|.:|.:..:...|||||...:.|||.|::|...|.:.::.||.|||.:.:::..
Yeast   216 PETLFLSINLMDRFLAKNKVTMNKLQLLAVTSLFIAAKFEEVNLPKLAEYAYITDGAASKNDIKN 280

  Fly   420 MERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTLTLARYILELSLMDYANISFSDSQMASAAL 484
            .|...|..:::::|.|....||||.::..........:.::|||.:...:..|....|.:::.|:
Yeast   281 AEMFMLTSLEFNIGWPNPLNFLRRISKADDYDPVNRNIGKFILEYAYCCHQFIHLPPSTVSAMAM 345

  Fly   485 FMALRMHGGPGQLDKQTWTSTLIYYTG---------YQ------LADFAEIVTALNAGL--HRKP 532
            ::|.||   ..:...:.|..||.:|:|         :|      :.|.|...|.|::.:  ::||
Yeast   346 YIARRM---TNRNKNELWNGTLQHYSGGIDPIHDEAFQSLCIDLVKDIASSKTHLDSLILKYKKP 407

  Fly   533 R 533
            |
Yeast   408 R 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	45/128 (35%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	27/116 (23%)
CLB5	NP_015445.1	COG5024	1..431	CDD:227357	112/456 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343526
Domainoid	1	1.000	50	1.000	Domainoid score	I2893
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9224
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
TreeFam	1	0.960	-	-
	8	7.800