DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB3 and CLB2

DIOPT Version :9

Sequence 1:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_015444.1	Gene:	CLB2 / 856236	SGDID:	S000006323	Length:	491	Species:	Saccharomyces cerevisiae

Alignment Length:	556	Identity:	143/556 - (25%)
Similarity:	231/556 - (41%)	Gaps:	127/556 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NVENMQTRAKRKADHSPIKNDKIKRSALGNLTNNVKIMTLHPAQDEEQSGVGKKPTAQQLQALMD 115
            |.||.|..:..:.    ::|  ::|.||.|:||..           .|......|.....::.::
Yeast     7 NTENSQNTSSSRF----LRN--VQRLALNNVTNTT-----------FQKSNANNPALTNFKSTLN 54

  Fly   116 AKKQENLSVNVFGASKMTTRASSKVEDSVENCHKVLDKLEEALARPK-----------PRPKAVP 169
            :.|:|...:..|      ||.|.....:.:...:.|.  |..:..||           |..:...
Yeast    55 SVKKEGSRIPQF------TRESVSRSTAAQEEKRTLK--ENGIQLPKNNLLDDKENQDPSSQQFG 111

  Fly   170 AAKKTVLGEVQLPAMPNPMQIPVLLPPTHNLAAPQVAAVKPVRRISNDFNKTEDSLYMSALEDVS 234
            |......|..:|||               |::..:.::.|.:  |.:|           .|:.|.
Yeast   112 ALTSIKEGRAELPA---------------NISLQESSSAKEI--IQHD-----------PLKGVG 148

  Fly   235 SCDSMRLSGNFEAARRRSAKLQQKTEQQPQPLLLTLPETAPSQVVPIPPVPE------------- 286
            |...: :..:.|..:...|:.|.:...       |..||...:..||..:.|
Yeast   149 SSTEV-VHNSVENEKLHPARSQLQVRN-------TESETDSGKKRPISTIVEQELPKKFKVCDEN 205

  Fly   287 -----EVEDFDRKNWDDPFQVSHYAMDIFNYLKVREA-EFPIAD--YMPRQIHLTTWMRTLLVDW 343
                 |.||.|.::.:|||.||.|..|||.||...|. ..|..:  |..|.||..   |.:||:|
Yeast   206 GKEEYEWEDLDAEDVNDPFMVSEYVNDIFEYLHQLEVITLPKKEDLYQHRNIHQN---RDILVNW 267

  Fly   344 MVEVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIACKYDERQPPLIEDFLYIC 408
            :|::...|.|..||||||:.|:|.:|.:|::..:||||:|.:..|||.||:|...|.|:.|....
Yeast   268 LVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASET 332

  Fly   409 DGAYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTLTLARYILELSLMDYANIS 473
            |||...||:...|:..|:.:|::|..|....||||.::.....:.:.|||:::||:||:|:..|.
Yeast   333 DGACTEDEIKEGEKFILKTLKFNLNYPNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIG 397

  Fly   474 FSDSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYTG-----------YQLADFAEIVTALNAG 527
            ...|..|:||:||:.:|      |.|..|...||:|:|           :.:.|:. :...::..
Yeast   398 ILPSLCAAAAMFMSRKM------LGKGKWDGNLIHYSGGYTKEELAPVCHMIMDYL-VSPIVHDE 455

  Fly   528 LHRKPRA-------------TIKTIRNKYSHKIFHE 550
            .|||.::             .:|..:|.|.....||
Yeast   456 FHRKYQSRRFMKASIISVQWALKVRKNGYDIMTLHE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	50/127 (39%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	37/140 (26%)
CLB2	NP_015444.1	COG5024	8..487	CDD:227357	140/549 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343518
Domainoid	1	1.000	50	1.000	Domainoid score	I2893
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9224
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
TreeFam	1	0.960	-	-
	9	8.830