DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB3 and CCNB3

DIOPT Version :9

Sequence 1:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_016885402.1	Gene:	CCNB3 / 85417	HGNCID:	18709	Length:	1404	Species:	Homo sapiens

Alignment Length:	689	Identity:	202/689 - (29%)
Similarity:	295/689 - (42%)	Gaps:	177/689 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QQAVNPILGALGAATRKGLTRRAAATGNIDPNVENMQTRAKRKADHSPIKNDKIKRSALGNLTNN 84
            :..:|.:|     |.::.|:..||.      |::...:..|:...|..:...| |:.||....|.
Human   722 ESLINKLL-----ALKEELSAEAAT------NIQTQLSLKKKSTSHGKVFFLK-KQLALNETINE 774

  Fly    85 VKIMTLHP---------------------AQDE---EQSGVGKKPTAQ---------QLQALMDA 116
            .:.:...|                     .|:|   |:..|.|:||..         .||.....
Human   775 EEFLNKQPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPST 839

  Fly   117 KKQENL---SVNVFGASKMTTRASSKVEDSVENCHKVLDKLEEAL-ARPKPRPKAV--------- 168
            :|:..|   ||:.....|.|.....|  .|:|  .:.|.|...|| .:|....:.:
Human   840 EKEAVLKEPSVDTEAHFKETLALQEK--PSIE--QEALFKRHSALWEKPSTEKETIFKESLDLQE 900

  Fly   169 -PAAKK-----------------TVLGEVQLPAMPNP-------MQIPVLL--PPTH-------N 199
             |:.||                 .||.|..:.....|       .:.|:.|  .||:       .
Human   901 KPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKEDTFLKT 965

  Fly   200 LAAPQ------VAAVKPVRRISNDFNKTEDSLYMSA-------LEDVSSCDSMRLSGNFEAARRR 251
            |..||      |::..|....|.....|..|:..|.       .||:.:.:....:|. |.:.:.
Human   966 LLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPTTGK-ELSFKE 1029

  Fly   252 SAKLQQKTEQQPQPLLLT--LPE---------TAPSQVV-------------------------- 279
            ...||:....:....|.|  :|:         |.|..:.
Human  1030 PLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVGKSRTTTESSACESA 1094

  Fly   280 ---PIPP----VPEEV----EDFDRKNWDDPFQVSHYAMDIFNYLKVREAE--------FPIADY 325
               |:.|    .|:|.    ||.|..:.|..|. ..||.:||:|:|.||.|        |.:.||
Human  1095 SDKPVSPQAKGTPKEQITPREDIDEDSSDPSFN-PMYAKEIFSYMKEREIEETAQSHEQFILTDY 1158

  Fly   326 MPRQIHLTTWMRTLLVDWMVEVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIA 390
            |.|||.:|:.||.:||||:||||.:||:.|||||||||:|||||.:.|..|:|||||||.||.||
Human  1159 MNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIA 1223

  Fly   391 CKYDERQPPLIEDFLYICDGAYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTL 455
            .|::|...|.::||:||||..|...|::.||...|.|:|.|:.||::|.||||||||....|.||
Human  1224 AKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTL 1288

  Fly   456 TLARYILELSLMDYANISFSDSQMASAALFMALRMHGGPGQLDKQT--WTSTLIYYTGYQLADFA 518
            ||:|||.|::|.:|..:....|::|:|:|.:||.|        |:.  |...|.:|:||.:::..
Human  1289 TLSRYICEMTLQEYHYVQEKASKLAAASLLLALYM--------KKLGYWVPFLEHYSGYSISELH 1345

  Fly   519 EIVTALNAGLHRKPRATIKTIRNKYSHKIFHEVAKVPLL 557
            .:|..||..|......::|.:..||||.:|.||||:|.|
Human  1346 PLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPAL 1384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	71/132 (54%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	48/121 (40%)
CCNB3	XP_016885402.1	Cyclin_N	1133..1266	CDD:306612	71/132 (54%)
CCNB3	XP_016885402.1	Cyclin_C	1268..1384	CDD:308564	49/123 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156575
Domainoid	1	1.000	150	1.000	Domainoid score	I4401
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto91544
orthoMCL	1	0.900	-	-		OOG6_106469
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.740