DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB3 and CycE

DIOPT Version :9

Sequence 1:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	130/550 - (23%)
Similarity:	204/550 - (37%)	Gaps:	166/550 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LGALGAATRKG--LTRRAAATGNIDPNVENMQTRAKRKADHSPIKNDKIKRSALGNLTNNVKIMT 89
            |.|..|||..|  ..||.::..|.||.:......|||:.                      ::..
  Fly    99 LAASTAATSNGNKRKRRLSSDSNEDPELGFEPPSAKRQQ----------------------RLPA 141

  Fly    90 LHPAQDEEQSGVGKKPTAQQLQALMDAKKQENLSVNVFGASKMTTRASSKVEDSVENCHKVLDKL 154
            |:.::....|.|........:.::.....||.||:.           ||..||           |
  Fly   142 LYGSEQGNLSSVASSVYTSPVVSVDGQSTQELLSIR-----------SSPAED-----------L 184

  Fly   155 EEALARPKP-RPKAVPAAKKTVLGEVQLPAMPNPMQIPVLLPPTHNLAAPQVAAVKPVRRISNDF 218
            .||...|.| .|.:.|:..:            ...|.||::    ..||.||.....|.:.:.|.
  Fly   185 SEAPHSPLPDSPDSPPSPDR------------GSKQTPVVV----RYAAEQVVTSTVVTQKTEDD 233

  Fly   219 NKTEDS----------------------LYMSALEDVSSCDSMRLSGNFEAARRRSAKLQQKTEQ 261
            :..:||                      :|.|.:...||..|.:.:.|.|    |:..|.:..||
  Fly   234 DLLDDSCEDYSYDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQQAVNGE----RTPGLPKHQEQ 294

  Fly   262 QPQPL--LLTLPETAPSQVV-------PIPPVPEEVEDFDRKNWDDPFQVSHYAMDIFNYLKVRE 317
            ...|:  |:....|..|..|       |:|.:.          |.:       |.|::..:..|:
  Fly   295 IHHPVSDLMINMRTPMSPAVENGLRQCPLPALA----------WAN-------AADVWRLMCHRD 342

  Fly   318 AEFPIADYMPRQIH-------LTTWMRTLLVDWMVEVQETFELNHETLYLAVKIVDLYL-CREVI 374
            .:    |...|.|.       |...||.:|:||::||.|.::|:.||.||||..:|.|| ....:
  Fly   343 EQ----DSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKV 403

  Fly   375 NKEKLQLLGAAAFFIACKYDERQPPLIEDFLYICDGAYNHDELVRMERETLRVIKYD-------- 431
            .|..|||:|....|:|.|.:|..||.|.:|.|:.|||....:::..|:..|:.:.:|
  Fly   404 QKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITG 468

  Fly   432 -LGI----------PLSYRFLRRYARCAKVP----MPTLTLARYI-----LELSLMDYANISFSD 476
             ||:          |.|:..:.| .:.|:..    .|..:...::     |:|..:|....::|.
  Fly   469 WLGVYMQLNVNNRTPASFSQIGR-QKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSY 532

  Fly   477 SQMASAALF------MALRMHGGPGQLDKQ 500
            |.:|:||:.      ||||..|    ||.|
  Fly   533 SVLAAAAISHTFSREMALRCSG----LDWQ 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	44/141 (31%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	20/80 (25%)
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	44/132 (33%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	15/45 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850