DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB3 and Ccnb3

DIOPT Version :9

Sequence 1:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_038956227.1	Gene:	Ccnb3 / 317389	RGDID:	1564367	Length:	1405	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	179/626 - (28%)
Similarity:	280/626 - (44%)	Gaps:	139/626 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ATTRAAITSGHHQLQQAVNPILGALGAATRKGLTRRAAATGNIDPNVENMQTRAKRKADHSP--- 67
            |..::.||......:..:.....|..|...|.|:....:...:....|.:.::.|.:|:...
  Rat   840 AIMKSLITEDESIKEAFIRSYTTATEAPAEKSLSLEETSINEVATLKEPLSSQEKHRAELVTVLK 904

  Fly    68 -----IKNDKIKRSALG---NLTNNVKIMTLHPAQDEEQSGVGKKPTAQQLQALMDAKKQENLSV 124
                 :||.:::|.||.   |..:||:.:........|:| .|::.|..:..||.:
  Rat   905 ELLVLVKNPRLERLALAFQENPPSNVETLLREVLALVEKS-TGEESTLNEPLALQE--------- 959

  Fly   125 NVFGASKMTTRASSKVEDSVENCHKVLDKLEEALARPKPRPKAVPAAKKTVLGEVQLPAMPNPMQ 189
                  |::|:|        |...|.|..||:.           |:.||
  Rat   960 ------KLSTKA--------ELSPKELLALEDN-----------PSFKK---------------- 983

  Fly   190 IPVLLPPTHNLAAPQVAAV---KP------VRRISNDFNK-TEDSLYMSAL-------------- 230
                       |:||.:..   ||      :.|:|..|.: :.||||...|
  Rat   984 -----------ASPQGSLTFDHKPDIEKDEITRMSFSFEEFSIDSLYEKVLALSEGFTTTEQLSF 1037

  Fly   231 EDVSSCDSMRL----------------------SGNFEAARRRSAKLQQKTE-----QQPQPLLL 268
            .|:.:.|..::                      |..||:.:..|:......|     ...:|.:.
  Rat  1038 TDLQNFDESKIVDEEDIFKSFFVFENENNPNLSSNGFESRKDNSSAPMPSLEAFNSVMNSEPCVS 1102

  Fly   269 TLPETAPS-------QVVPIPPVPEEVEDFDRKNWDDPFQVSHYAMDIFNYLKVREAEFPIADYM 326
            ....:..|       ||: |....:..|.|.::: .|....|.||.:||.|||.||.:|.:..||
  Rat  1103 ATKSSQSSLGGKETEQVI-ILDDSDTQESFVKED-SDLLLSSTYAKNIFIYLKEREEKFIVTKYM 1165

  Fly   327 PRQIHLTTWMRTLLVDWMVEVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIAC 391
            ..|:.||:.||.:|||||||||..|.::|||||||||::|.||.:....|..|||||:.|:.||.
  Rat  1166 DEQMELTSDMRAILVDWMVEVQANFRMSHETLYLAVKLMDRYLMKAQCEKNHLQLLGSTAYMIAA 1230

  Fly   392 KYDERQPPLIEDFLYICDGAYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTLT 456
            |::|..||.:.:|||||:..|...|:|.:||..|:.:.:|:.||::|.||||||.|....|.|||
  Rat  1231 KFEESYPPSLTEFLYICEDLYPKSEMVSLERNILKTLNFDINIPIAYHFLRRYASCIHASMKTLT 1295

  Fly   457 LARYILELSLMDYANISFSDSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYTGYQLADFAEIV 521
            |:|:|.|::|.:|..|....|::|:|:..:||.|.      :.:....:|.|.||||||:...:|
  Rat  1296 LSRFICEMTLQEYDYIDERPSKLAAASFILALYMR------NLKDCVPSLEYSTGYQLAELHILV 1354

  Fly   522 TALNAGLHRKPRATIKTIRNKYSHKIFHEVAKVPLLTNQEL 562
            ..||..|:.:.|..:|.:..|||.:.:.||||:|.|:.::|
  Rat  1355 RKLNHLLNFRSRTVLKNVFEKYSEETYFEVAKIPPLSMKDL 1395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	62/124 (50%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	47/119 (39%)
Ccnb3	XP_038956227.1	CYCLIN_SF	1133..1270	CDD:424085	65/137 (47%)
Ccnb3	XP_038956227.1	CYCLIN_SF	1274..1388	CDD:424085	47/119 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350490
Domainoid	1	1.000	133	1.000	Domainoid score	I4948
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto98618
orthoMCL	1	0.900	-	-		OOG6_106469
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.710