DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB3 and cig2

DIOPT Version :9

Sequence 1:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_593889.1	Gene:	cig2 / 2543481	PomBaseID:	SPAPB2B4.03	Length:	411	Species:	Schizosaccharomyces pombe

Alignment Length:	422	Identity:	119/422 - (28%)
Similarity:	184/422 - (43%)	Gaps:	54/422 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 MTTRASSKVEDSVENCHKVLDKLEEALARPKPRPKAVPAAKKTVLGEVQLPAMPNPMQIPVLLPP 196
            |...:.||...|..|.|...|  |..|...:...|.....|.:...|:.||..       .:|..
pombe     1 MALYSISKPVGSKINKHSYQD--ENTLVGKQALSKGTEKTKLSTNFEINLPRR-------TVLSD 56

  Fly   197 THNLAAPQVAAVKPVRRISNDFNKTEDSLYMSALEDVSSCDSMRLSGNFEAARRRSAKLQQKTE- 260
            ..|:.... |..|..::....|                  |...||.|.||.:...:|..:|.:
pombe    57 VSNVGKNN-ADEKDTKKAKRSF------------------DESNLSTNEEADKPVESKFVKKLKV 102

  Fly   261 --QQPQPLLLTLPETAPSQVVPIPPVPEEVEDFDRKNWDDPFQVSHYAMDIFNYLKVREAE-FPI 322
              :...|.:.||.:             :.|.:.|.....:|.....||.:||.|::..:.: .|.
pombe   103 YSKNADPSVETLQK-------------DRVSNVDDHLSSNPLMAEEYAPEIFEYIRKLDLKCLPN 154

  Fly   323 ADYMPRQIHLTTWMRTLLVDWMVEVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAF 387
            ..||.:|..||..||.:|.:|:||:...|.|..|||||||.|:|.:|.|...:..|.||.|..|.
pombe   155 PKYMDQQKELTWKMREILNEWLVEIHSNFCLMPETLYLAVNIIDRFLSRRSCSLSKFQLTGITAL 219

  Fly   388 FIACKYDERQPPLIEDFLYICDGAYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPM 452
            .||.||:|...|.|::|:|:.|||:..:::...||..|.|:.:||..|....|||:.::......
pombe   220 LIASKYEEVMCPSIQNFVYMTDGAFTVEDVCVAERYMLNVLNFDLSYPSPLNFLRKISQAEGYDA 284

  Fly   453 PTLTLARYILELSLMDYANISFSDSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYT-GYQLAD 516
            .|.||.:|:.|:.|.|:..:.:..|::|:||::::.|:      |.:..||..|:..: ||:..:
pombe   285 QTRTLGKYLTEIYLFDHDLLRYPMSKIAAAAMYLSRRL------LRRGPWTPKLVESSGGYEEHE 343

  Fly   517 FAEIVTALNAGLHRKPRATIKTIRNKYSHKIF 548
            ..||...: ...|.|| ...|....|||.|.|
pombe   344 LKEIAYIM-LHYHNKP-LEHKAFFQKYSSKRF 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	50/125 (40%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	33/115 (29%)
cig2	NP_593889.1	COG5024	1..399	CDD:227357	119/422 (28%)
		Cyclin_N	139..265	CDD:278560	50/125 (40%)
		Cyclin_C	267..382	CDD:281044	33/115 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3040
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47403
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	1	1.000	-	-		X94
TreeFam	1	0.960	-	-
	8	7.900