DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB3 and Ccnb3

DIOPT Version :9

Sequence 1:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_898836.2	Gene:	Ccnb3 / 209091	MGIID:	2183443	Length:	1396	Species:	Mus musculus

Alignment Length:	542	Identity:	162/542 - (29%)
Similarity:	272/542 - (50%)	Gaps:	72/542 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 ENMQTRAKRKADHSPI--------KNDKIKRSALG---NLTNNV-----KIMTLHPAQDEEQSGV 101
            |::.::.|.:|:...:        ||..:||.||.   |.:|||     :::.|......::|.:
Mouse   885 ESLSSQEKHRAELVTVLKELLVLMKNPSLKRVALAFQENPSNNVETLLREVLALVENSTADESTL 949

  Fly   102 GKKPTAQQLQALMDAKKQENLSVNVFGASKMTTRASSKVEDSVENCHKVLDKLEEALARPKPRPK 166
            .:||:.:     .|...:|.|::....::|     .:...||:...||
Mouse   950 QEKPSTK-----TDVTPKELLALEENSSNK-----KANPMDSLSFDHK----------------- 987

  Fly   167 AVPAAKKTVLGEV-QLPAMPNPMQIPVLLPPTHNLAAPQVAAVKPVRRISNDFNKT----EDSLY 226
                 ..|.:||: ::........|..|......|:...:||.:.......:|.:|    |:..:
Mouse   988 -----PDTEMGEIARMVLTDEEYNIDTLYERVLALSQGLIAADQLSFTDLQNFEETKIVDEEEFF 1047

  Fly   227 MSALEDVSSCDSMRLSGN-FEAARRRSAKLQQKTE-----QQPQPLL---LTLPETAPSQVVPIP 282
            .|.|. ..:.:|..:|.| ||:....|:.:...::     :...|.:   .:...|..::...|
Mouse  1048 KSFLV-FENKNSPNMSSNAFESRTDNSSAIMPSSKAFNPVENSNPYVSSSKSFKSTLGAKETEI- 1110

  Fly   283 PVPEEVEDFDR--KNWDDPFQVSHYAMDIFNYLKVREAEFPIADYMPRQIHLTTWMRTLLVDWMV 345
            .:.::.:..:|  |...||...:.||.|:|||||.||.:|.:..||..|:.||:.||.:||||:|
Mouse  1111 TIQDDSDSLERIEKEGQDPLLNTIYAKDVFNYLKEREEKFLVQKYMDGQMELTSDMRAILVDWLV 1175

  Fly   346 EVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIACKYDERQPPLIEDFLYICDG 410
            |:|.:|::.||||||||||:||||.:....|..|||||:..:.||.|::|..||.:.:||:||:.
Mouse  1176 EIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICED 1240

  Fly   411 AYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTLTLARYILELSLMDYANISFS 475
            .|...::|.:|...|:.:.:|:.||.:|.||||||.|....|.||||:|:|.|::|.:|..|...
Mouse  1241 MYEKSDMVSLESSILQTLNFDINIPTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEER 1305

  Fly   476 DSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYTGYQLADFAEIVTALNAGLHRKPRATIKTIR 540
            .|::|:|:..:||.|.      :......||.|:|||::|:...:|..||..|:.:..:.:|.:.
Mouse  1306 PSKLAAASFILALYMR------NLSNCVPTLEYFTGYKMAELHILVRKLNHLLNFRSHSILKNVF 1364

  Fly   541 NKYSHKIFHEVAKVPLLTNQEL 562
            .|||.:.:.||||:|.|:.|:|
Mouse  1365 EKYSEETYFEVAKIPPLSKQDL 1386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	59/124 (48%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	45/119 (38%)
Ccnb3	NP_898836.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		D-box	54..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..398
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..796
		COG5024	<1054..1372	CDD:227357	116/324 (36%)
		Cyclin_N	1138..1263	CDD:365896	59/124 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846988
Domainoid	1	1.000	133	1.000	Domainoid score	I5052
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto95125
orthoMCL	1	0.900	-	-		OOG6_106469
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R194
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.740