DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycB3 and cye-1

DIOPT Version :9

Sequence 1:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001021027.1	Gene:	cye-1 / 172399	WormBaseID:	WBGene00000871	Length:	524	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	118/492 - (23%)
Similarity:	197/492 - (40%)	Gaps:	108/492 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RRAAATGNIDPNVENMQTRAKRKADHSPIKNDKIKRSALGNLTNNVKIMTLHPAQDEEQSGVGKK 104
            |:::.|....|..:..:.::...:.|..:: :::..:|: ::..|:      |.::...|.||
Worm     4 RKSSRTAERVPTTQKPERKSAILSPHDELR-ERLLETAI-DMKENI------PQRNTRNSSVG-- 58

  Fly   105 PTAQQLQALMDAKKQENLSVNVFGASKMTT----RASSKVEDSVENCHKVLDKLE-EALARPKPR 164
               .|.....:.:|:.  |.....|:|..:    |..|: |||:|...:..|..| .:.:....|
Worm    59 ---SQKSDCSETRKRR--STKEGPAAKRHSGEKHRNGSR-EDSLEYISEYSDDREVGSSSSQSSR 117

  Fly   165 PKAVPAAKKTVLGEVQLPAMPNPMQIPVLLPPTHNLAAPQVAAVKPVR---------RISNDFNK 220
            .:..|           |||||...::......:.|||..: .:.:.||         .|.:||:.
Worm   118 TRGQP-----------LPAMPEEEEVFDKSSSSDNLAESE-ESHEMVRLEERQDIEEEIEDDFDD 170

  Fly   221 TEDSLY--MSALEDVSSCDS----MRLSGNFEAARRRSAKLQQKTEQQPQPLLLTLPETAPSQVV 279
            .|:.:.  ....|::.|.|.    ::..| |...:|    |.........|..|:   ||....:
Worm   171 EEEDVVNDKEEYEEIESEDEDDYPVQNEG-FAVTKR----LMNDEHMVTAPTFLS---TAKCDGI 227

  Fly   280 PIPPVPEEVEDFDRKNWDDPFQVSHYAMDIFNYLKVREAEFPIADYMPRQIH--LTTWMRTLLVD 342
            ..|          .|.|.               |.|:..|.|.|.......|  :....|.:|:|
Worm   228 GSP----------TKVWS---------------LMVKRDEIPRATRFLLGNHPDMDDEKRRILID 267

  Fly   343 WMVEVQETFELNHETLYLAVKIVDLYLCREVINKE----KLQLLGAAAFFIACKYDERQPPLIED 403
            ||:||.|:.:|:.||.:|||..||.||  |..|.|    ..||:|.||.|||.||:|..||...|
Worm   268 WMMEVCESEKLHRETFHLAVDYVDRYL--ESSNVECSTDNFQLVGTAALFIAAKYEEIYPPKCID 330

  Fly   404 FLYICDGAYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARC--------------AKVPMPT 454
            |.::.|.|:..|.:..||...::.|.:.||...|.::|..|.:.              ..:.:|.
Worm   331 FAHLTDSAFTCDNIRTMEVLIVKYIGWSLGPITSIQWLSTYLQLLGTGKKNKSDHYEEQNMYVPE 395

  Fly   455 LTLARY-----ILELSLMDYANISFSDSQMASAALFM 486
            |..:.|     ||:..|.:..:.:||...:|:|.||:
Worm   396 LLRSEYLEMCKILDFLLFEIDSFTFSYRTIAAAVLFV 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	48/130 (37%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	15/71 (21%)
cye-1	NP_001021027.1	Cyclin_N	233..360	CDD:278560	49/143 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920