DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycB3 and Ccne1

DIOPT Version :9

Sequence 1:	NP_001262934.1	Gene:	CycB3 / 42971	FlyBaseID:	FBgn0015625	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_031659.2	Gene:	Ccne1 / 12447	MGIID:	88316	Length:	408	Species:	Mus musculus

Alignment Length:	413	Identity:	100/413 - (24%)
Similarity:	165/413 - (39%)	Gaps:	111/413 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 KTEDSLYMSALEDVSSCD-SMRLSGNFEAARRRSAKLQQKTEQQPQPLLLTLPETAPSQVVPIPP 283
            :..||...|.:::....| |:|       :|:|.|.:.... |.|...:..:.:|..|:....|
Mouse     3 RERDSTDHSNMKEEGGSDLSVR-------SRKRKANVAVFL-QDPDEEIAKIDKTVKSEDSSQP- 58

  Fly   284 VPEEVEDFDRKNWDDPFQVSHYAMDIFNYLKV------REAEFPIADYMPRQIH--------LTT 334
                        |||    :...:|..:::..      .|.|:|...:.||:|.        :..
Mouse    59 ------------WDD----NSACVDPCSFIPTPNKEEDNELEYPRTAFQPRKIRPPRASPLPVLN 107

  Fly   335 W---------------------------------MRTLLVDWMVEVQETFELNHETLYLAVKIVD 366
            |                                 ||.:|:||::||.|.::|:.||.|||....|
Mouse   108 WGNREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFD 172

  Fly   367 LYLC-REVINKEKLQLLGAAAFFIACKYDERQPPLIEDFLYICDGAYNHDELVRMERETLRVIKY 430
            .|:. :..|.|..|||:|.:|.|||.|.:|..||.:..|.|:.|||.:.||::.||...::.:|:
Mouse   173 RYMASQHNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKW 237

  Fly   431 DLGIPLS-YRFLRRYARCAKV-----------PMPTLTLARYILELSLMDYANISFSDSQMASAA 483
            .|. ||: ..:|..|.:.|.|           |.........:|:|.::|...:.|....:|::|
Mouse   238 RLS-PLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFPYGVLAASA 301

  Fly   484 LFMALRMHGGPGQLDKQTWTSTLIYYTGYQLADFAEIVTALNAGLHRKPRATIKTIRNKYSHKIF 548
            |:     |....:|.::.        :|||..|..:.|..:      .|.|.:  ||...|.|:.
Mouse   302 LY-----HFSSLELMQKV--------SGYQWCDIEKCVKWM------VPFAMV--IREMGSSKLK 345

  Fly   549 HEVAKVPL--LTNQELFQGNLDL 569
            | ...||:  ..|.:....:|||
Mouse   346 H-FRGVPMEDSHNIQTHTNSLDL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	48/172 (28%)
CycB3	NP_001262934.1	Cyclin_C	435..555	CDD:281044	28/131 (21%)
Ccne1	NP_031659.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		6/30 (20%)
		Cyclin_N	113..240	CDD:278560	40/126 (32%)
		Cyclin_C	243..362	CDD:281044	29/140 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..408
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820