DRSC/TRiP Functional Genomics Resources

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Protein Alignment KMT2A and SET1

DIOPT Version :10

Sequence 1:XP_011541131.1 Gene:KMT2A / 4297 HGNCID:7132 Length:4005 Species:Homo sapiens
Sequence 2:NP_011987.1 Gene:SET1 / 856519 SGDID:S000001161 Length:1080 Species:Saccharomyces cerevisiae


Alignment Length:614 Identity:152/614 - (24%)
Similarity:227/614 - (36%) Gaps:190/614 - (30%)


- Green bases have known domain annotations that are detailed below.


Human  3488 LQHVN----------------QLLASKTGIHSSQR--------DLDSASGPQVSNFTQTVDAPNS 3528
            |.|.|                |.:|||......:|        ||....|....:..:.:...||
Yeast   561 LDHANFPELLAKRELKEKEKRQQIASKIAEDELKRKEEAKRDFDLFGLYGGYAKSNKRNLKRHNS 625

Human  3529 MGLE----QNKALSSAV--------------QASPTSPGG------SPSSPSSGQRSASPSVPGP 3569
            :.|:    :.|.||:.:              :.:|.:..|      ..........|:|......
Yeast   626 LALDHTSLKRKKLSNGIKPMAHLLNEETDSKETTPLNDEGITRVSKEHDEEDENMTSSSSEEEEE 690

Human  3570 TKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQ 3634
            ..|..|.|....|....:...|.:..|        :|||..:|            :..|.:|:.:
Yeast   691 EAPDKKFKSESEPTTPESDHLHGIKPL--------VPDQNGSS------------DVLDASSMYK 735

Human  3635 SSQKECGQPAGQVAVLPEVQV------------TQNPANEQE---------SAEPKTVEEEESNF 3678
            .:..|..:|     |.|..:.            .||...::|         |....||..|.| .
Yeast   736 PTATEIPEP-----VYPPEEYDLKYSQTLSSMDLQNAIKDEEDMLILKQLLSTYTPTVTPETS-A 794

Human  3679 SSPLMLWLQQEQKRKESITEKKPK------KGLVFEISSDDGFQICAESIEDAWKSLTDKVQEAR 3737
            :....:|    |.|::.:.|:|..      .|.:|:.....|....||    .::.:.||::   
Yeast   795 ALEYKIW----QSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAE----GFRKIADKLK--- 848

Human  3738 SNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKP-------EEANEPPLN 3795
                        :|.|                    .|.|    |.|:|       .|.||  ..
Yeast   849 ------------INYL--------------------PHRR----RVHQPLNTVNIHNERNE--YT 875

Human  3796 PHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNP------------NDEEEEEVQLKSARRATSM 3848
            |....|.|               |.:::|.:..|            |...:::::.:.|...|..
Yeast   876 PELCQREE---------------SSNKEPSDSVPQEVSSSRDNRASNRRFQQDIEAQKAAIGTES 925

Human  3849 DLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDS 3913
            :|   :....|.| .|:.|...||.||..||:...:|.|.||:|||.|..||....:.|||.|..
Yeast   926 EL---LSLNQLNK-RKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLK 986

Human  3914 KGIG-CYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELT 3977
            .||| .|:||:|::.|:|||..|..||||||.|:|||.:::|.:.|::.|||:|:|.|...||||
Yeast   987 NGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELT 1051

Human  3978 YDYKFPIE-DASNKLPCNCGAKKCRKFLN 4005
            |||||..| |...:|||.|||..|:.|||
Yeast  1052 YDYKFEREKDDEERLPCLCGAPNCKGFLN 1080

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KMT2AXP_011541131.1 zf-CXXC 1180..1227 CDD:366873
PHD1_KMT2A 1466..1512 CDD:277063
PHD2_KMT2A 1514..1563 CDD:277065
PHD3_KMT2A 1601..1660 CDD:277067
Bromo_ALL-1 1683..1813 CDD:99925
ePHD_KMT2A 1907..2019 CDD:277163
FYRN 2060..2107 CDD:461787
FYRC 3705..3788 CDD:197781 13/89 (15%)
SET_KMT2A_2B 3852..4005 CDD:380947 73/154 (47%)
SET1NP_011987.1 AF-4 <11..>136 CDD:461550
RRM_scSet1p_like 246..360 CDD:409743
SET_assoc 422..486 CDD:432058
N-SET 763..932 CDD:463344 40/236 (17%)
SET_SET1 926..1076 CDD:380998 72/153 (47%)
Blue background indicates that the domain is not in the aligned region.

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