DRSC/TRiP Functional Genomics Resources

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Protein Alignment KMT2A and pie

DIOPT Version :9

Sequence 1:XP_011541131.1 Gene:KMT2A / 4297 HGNCID:7132 Length:4005 Species:Homo sapiens
Sequence 2:NP_001260348.1 Gene:pie / 44315 FlyBaseID:FBgn0005683 Length:582 Species:Drosophila melanogaster


Alignment Length:634 Identity:128/634 - (20%)
Similarity:213/634 - (33%) Gaps:184/634 - (29%)


- Green bases have known domain annotations that are detailed below.


Human  1903 IEDNR--QCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFE---DDDG----SLKNVH 1958
            :|||:  ||.:| .|.|......|..:.: :|...|..|.|.|..:.:   |..|    .|:::.
  Fly     1 MEDNKELQCLIC-KYSDTDDLVFGEWMIV-RNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIR 63

Human  1959 MAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCV--FLDDKKVYCQRHR--DLIKG 2019
            ......::.:|.:|.|.||::.|  ..|.|.:|..|......|  |....|.||.:.|  |..|.
  Fly    64 EEAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDDYKR 126

Human  2020 EV---VPEN--------------------------GF--EVFRRVFVDFEGISLR------RKFL 2047
            ::   .|.|                          ||  :...|.:....|..||      .:|.
  Fly   127 QLQSNPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSGYYLRCIWCRSERFR 191

Human  2048 NGL---------------EPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYW----- 2092
            :.:               :..|.:..:....:.|     |..:|   |.|.|...:|:.|     
  Fly   192 DSIRLQSVFVPDRDATWEKQRNAYRELHERNLKC-----DQPNC---LCPSGRTYNRLSWVILCC 248

Human  2093 ---STTDARKRC-VYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAE-- 2151
               :.|.|..:| |...::.:.|.   ..|...::..|..|.||..|...||.::.:..|..:  
  Fly   249 SSCAATSAHLKCLVGALRLPKKRE---RTDFKCSMCLDVERRIAEGPARTTEETNADGDNQVDGS 310

Human  2152 -IISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYS---PTQRSPG-----CRPLPSAGS---- 2203
             .:....||....|.|               :||.:|   .::||..     .:|..:|.|    
  Fly   311 FYVQKLGPDAATRSLT---------------QTPVFSEEDESERSSNITVIFSQPKSNATSERLS 360

Human  2204 -PTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTG 2267
             ..|....||.:.|                    ||:.|....:....:....:|.:.|......
  Fly   361 LSPPQEEMIVEIPD--------------------SPEASPKTSIDENHSPQPIARRDTSDSPQPI 405

Human  2268 TATDLESSAKVVDHVLGPLNSS--TSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSAS 2330
            .|:::..|.:       |..:|  ..|.|.|:.:.|.:.|..|..|...|     |.:.:.|.::
  Fly   406 AASEIPDSPQ-------PTAASEIPDLPQTTAINVNPELTQQTALNTIPH-----SPQPEASFST 458

Human  2331 DLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSF 2395
            .|||::......:.:.::...:.        |.:||..|   ||    |.|.|.| |..|.. .|
  Fly   459 QLVSQTFDCPQPQEQAVAKAPNS--------PSLPKEDP---NT----LLVLKSG-FQCPGE-PF 506

Human  2396 SSKEALSFPHLHLRGQ---------RNDRDQHTDSTQSA----NSSPDE 2431
            .......|.|....|:         :.|..:..|::|:|    |.:||:
  Fly   507 FYLVIYEFEHGTCMGECIGTCVLRFKEDDPRIQDTSQAALERVNITPDD 555

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KMT2AXP_011541131.1 zf-CXXC 1180..1227 CDD:251032
PHD1_KMT2A 1466..1512 CDD:277063
PHD2_KMT2A 1514..1563 CDD:277065
PHD3_KMT2A 1601..1660 CDD:277067
Bromo_ALL-1 1683..1813 CDD:99925
ePHD_KMT2A 1907..2019 CDD:277163 31/124 (25%)
FYRN 2061..2107 CDD:283589 12/54 (22%)
FYRC 3705..3788 CDD:197781
SET <3861..4005 CDD:225491
SET 3867..3987 CDD:214614
PostSET 3989..4005 CDD:214703
pieNP_001260348.1 PHD_SF 9..117 CDD:304600 28/111 (25%)
PHD_SF 224..>260 CDD:304600 10/43 (23%)
PARM 318..>491 CDD:293666 42/230 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1084
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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