Protein Alignment KMT2A and NSD

DIOPT Version :10

• Sequence 1: XP_011541131.1
• Gene: KMT2A / 4297
• HGNCID: 7132
• Length: 4005
• Species: Homo sapiens
• Sequence 2: NP_733239.1
• Gene: NSD / 43351
• FlyBaseID: FBgn0039559
• Length: 1427
• Species: Drosophila melanogaster
• Alignment Length: 1626
• Identity: 307/1626 - (18%)
• Similarity: 512/1626 - (31%)
• Gaps: 591/1626 - (36%)

Human  2696 SAEGQV---DGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVD 2757
            :|.|.|   ..:|.|:.:||            :::|.:|.:|:     |.:..::|:
  Fly    15 AAHGNVLCNSASDSLTATDE------------VAAGNDESVAT-----EGDDVEIPR-------- 54

Human  2758 DGTESDTSVTATTR---KSSQIPKRNGKENGTE--NLKIDRPEDAGEKEHVTKSSVGHKNEPKMD 2817
                 ||:.:...|   |..|.|.:||.:...|  .|:..|.....:::....|.|..|.:  :.
  Fly    55 -----DTNNSTPVRLLDKPGQNPVQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKRD--LI 112

Human  2818 NCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNT---ELLKSDS---------D 2870
            |..|....|..|..:..:.....:|...:.|:...........|:   |.|..|:         .
  Fly   113 NLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGG 177

Human  2871 NNNSDDCGNIL-----PSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLF 2930
            ....||..|.|     .|.|...::||..|      ||.|:.                      |
  Fly   178 GGGGDDSANQLLSKTYMSPIEKLLIKNGAS------SPNSTG----------------------F 214

Human  2931 EVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKR 2995
            |..|:.|.....|...|...:....:.::.|||..                           :.:
  Fly   215 EAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDE---------------------------KNQ 252

Human  2996 VTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTR 3060
            ..:.||||.:...|..:......||.|...|... |:...:|:|.::...      |...:|..|
  Fly   253 QEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAIS-IKSETEAEHKAAVDV------HIKQEDTIR 310

Human  3061 NSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLY 3125
                          :.|.|           .|.:.::..:...|..|:.:||:|..
  Fly   311 --------------LDIVN-----------NPVESTSIVITEEPKDLEKSTEELAF--------- 341

Human  3126 VLQTLPNGVTQKIQLTS--SVSST--PSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQ--SLFPS 3184
               .||...:.::.|.|  .:|||  .:.:::.:||......||::.|  :|..||.|  .||..
  Fly   342 ---ALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVT--DPGWPTYQVGDLFWG 401

Human  3185 ASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQ---------------LLV 3234
                             ...:...:|..:...|.|.::| ..|..||               ...
  Fly   402 -----------------KVFSYCFWPCMVCPDPLGQIVG-NMPSHPQRSSLDNANVPIQVHVRFF 448

Human  3235 SESSQRTDLSTTVATPSSGLKKRPISRLQTR--------KNKKLAPSSTPSNIAPSDVVSNMTLI 3291
            :::.:|..:........:|||.....|.:.|        |.:::.|..|...|....:.....:
  Fly   449 ADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAM- 512

Human  3292 NFTPSQLPNHPSLLDLGSLNTSSHRTVPNII-----KRSKSSIMYFEPAPLLPQSVGGTAATAAG 3351
                :|:|....|       ...::|..|::     ||.::..|
  Fly   513 ----TQIPYSDRL-------EKFYQTYENVVTLNRQKRKRTKYM--------------------- 545

Human  3352 TSTISQDTSHLTSG---SVSGLASSSSV-LNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIG 3412
                .||||.:.|.   |...|.:.... |..|..:.:.:|.|.|..|  |...|.:
  Fly   546 ----MQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSP--VKSKNEK-------- 596

Human  3413 SISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAAS 3477
                   :|.::.|           |:|            |.|.|.::|:.|.||...|  |..|
  Fly   597 -------RAKRRKL-----------SNG------------TEADTGSNSMAVTPSQTET--TVDS 629

Human  3478 PSGEADEHYQL--------------QHVNQLLAS---------KTGIHSSQRDLDSASG----PQ 3515
            .:.|..|..||              :.|.::|.|         :..:...:|||  |||    |.
  Fly   630 SAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDL--ASGEIEEPL 692

Human  3516 VSNFTQTVDAPNSMGLEQNKALSSAVQASPT---SPGGSPSSPSSGQRSASPSVPGPTKPKPKTK 3577
            .|:.........::....|:.::..|:.|.|   :|..:|:.....:|.:.|    |...||..:
  Fly   693 GSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEPDRRLSEP----PKTKKPVNR 753

Human  3578 RFQ------LPLD-----KGNGKK-----------HKVSHLRTSSSEAHIP--DQETTSL----- 3613
            ..:      |.||     :|..::           ..|...||.||..|..  :::.|..
  Fly   754 PIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKI 818

Human  3614 ----------TSGTGTPGAE---AEQQDTASVEQSSQ-KEC--GQPAGQVAVLPEVQVTQNPANE 3662
                      ||.:.:|..:   |:.::..:|..|.. .||  |:|.|.|.           .::
  Fly   819 GSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVI-----------CHQ 872

Human  3663 QES-AEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGF----------- 3715
            .|| |.|.|..:|:|:..:|:      |.|   .:|..:|..|..|..|....:
  Fly   873 VESPAVPSTPRKEDSSSHTPI------EDK---LLTCSQPMCGKRFHTSCCKYWPQASSSKHSAR 928

Human  3716 ---QICAESIEDAWKSLTDKVQE---------ARSNARLKQLSF---AGVNGLRMLGIL------ 3759
               .:|...:.|   ..:.|.|:         .|..|...|||.   ||...|....|:
  Fly   929 CPRHVCHTCVSD---DPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNI 990

Human  3760 -----HDAVVFLIEQLSGAK-------------HCRNYKFRFHKP---EEA-------------- 3789
                 |..|::....:.|.:             ||||...:.::.   ||.
  Fly   991 AKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWA 1055

Human  3790 ---------------NEPPLN----PHGS----------------ARAEVHL---------RKSA 3810
                           .|.|.|    .||.                :|..|:|         .|:.
  Fly  1056 KFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTK 1120

Human  3811 FDMFNFLASKHRQPPEYNP---NDEEEEEVQLKSARR---------ATSMDLPMPMRF------- 3856
            ..:|....:...:...:.|   ...:|::::.:|..:         .|:..:| |:||
  Fly  1121 SQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVP-PLRFSQNLEDL 1184

Human  3857 -----------------------------------------RHLKKTSKEAVGVYRSPIHGRGLF 3880
                                                     |..::.....:.|......|.||.
  Fly  1185 STCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLV 1249

Human  3881 CKRNIDAGEMVIEYAGNVIRSI---------QTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN 3936
            .:..|..|:.||||.|.||...         |.|:.|.|        |...::...::||...||
  Fly  1250 NREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENY--------YFLGVEKDFIIDAGPKGN 1306

Human  3937 AARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASN--KLPCNCGAKK 3999
            .|||:||||||||.::...::....:.|||::.|....|||::|.:  :|..|  |..|.||||:
  Fly  1307 LARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLW--DDLMNNSKKACFCGAKR 1369

Human  4000 C 4000
            |
  Fly  1370 C 1370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:366873
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163
		FYRN	2060..2107	CDD:461787
		FYRC	3705..3788	CDD:197781	22/135 (16%)
		SET_KMT2A_2B	3852..4005	CDD:380947	54/208 (26%)
NSD	NP_733239.1	PWWP_NSD_rpt1	395..514	CDD:438972	19/141 (13%)
		PHD2_NSD	867..932	CDD:277040	16/84 (19%)
		PHD3_NSD	933..988	CDD:277041	13/57 (23%)
		PHD4_NSD	1001..1041	CDD:277042	6/39 (15%)
		PWWP_NSD_rpt2	1048..1143	CDD:438963	11/94 (12%)
		AWS	1183..1233	CDD:197795	1/49 (2%)
		SET_NSD	1233..1375	CDD:380950	50/148 (34%)