DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KMT2A and CG4565

DIOPT Version :9

Sequence 1:	XP_011541131.1	Gene:	KMT2A / 4297	HGNCID:	7132	Length:	4005	Species:	Homo sapiens
Sequence 2:	NP_001097743.1	Gene:	CG4565 / 41303	FlyBaseID:	FBgn0037841	Length:	269	Species:	Drosophila melanogaster

Alignment Length:	286	Identity:	75/286 - (26%)
Similarity:	116/286 - (40%)	Gaps:	81/286 - (28%)

- Green bases have known domain annotations that are detailed below.

Human  3761 DAVVFLIEQL----SGAKHCRNYKFRFHKPEEANEPPLNP--------------HGSA------R 3801
            |.:.:::|.:    .|:|     :|:| ..:|.|...|||              ||..      .
  Fly    16 DGLDYILESVLMPSDGSK-----EFKF-LADEYNSVLLNPCHCKGACENSEVCAHGGQYEFTEDG 74

Human  3802 AEVHLRKSAFDMFNFLASKHRQPPEYNP----NDEEEEEVQLKSARRATSMDLPMPMRFRHLKKT 3862
            :|:.||.||                 ||    ||      ..|..|...|..|......:||:
  Fly    75 SELILRNSA-----------------NPVIECND------MCKCCRNTCSNRLVYSGPRKHLE-- 114

Human  3863 SKEAVGVYRSPIHG-RGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDS 3926
                  ::.||::| :||.....|..|..:.||||.::  ...:.|.:.:|::.:|...:.:..:
  Fly   115 ------IFDSPVYGSKGLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGLMNYILVLN 171

Human  3927 E----------VVDATMHGNAARFINHSCEPNCYSRVINIDGQ-KHIVIFAMRKIYRGEELTYDY 3980
            |          :||.:..||..|::||||||||:...:.||.. ..|.|||.|.|...|||.:.|
  Fly   172 EYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEELCFHY 236

Human  3981 --KFPIEDASNKLPCNCGAKKCRKFL 4004
              :...:..:....|.|||.||..|:
  Fly   237 GGEGQYKKMTGGKTCLCGASKCTGFM 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:251032
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163
		FYRN	2061..2107	CDD:283589
		FYRC	3705..3788	CDD:197781	6/30 (20%)
		SET	<3861..4005	CDD:225491	47/158 (30%)
		SET	3867..3987	CDD:214614	40/133 (30%)
		PostSET	3989..4005	CDD:214703	7/16 (44%)
CG4565	NP_001097743.1	Pre-SET	10..103	CDD:282838	25/115 (22%)
CG4565	NP_001097743.1	SET	111..239	CDD:214614	42/137 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840