Protein Alignment KMT2A and CG4565

DIOPT Version :10

• Sequence 1: XP_011541131.1
• Gene: KMT2A / 4297
• HGNCID: 7132
• Length: 4005
• Species: Homo sapiens
• Sequence 2: NP_001097743.1
• Gene: CG4565 / 41303
• FlyBaseID: FBgn0037841
• Length: 269
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 75/286 - (26%)
• Similarity: 116/286 - (40%)
• Gaps: 81/286 - (28%)

Human  3761 DAVVFLIEQL----SGAKHCRNYKFRFHKPEEANEPPLNP--------------HGSA------R 3801
            |.:.:::|.:    .|:|     :|:| ..:|.|...|||              ||..      .
  Fly    16 DGLDYILESVLMPSDGSK-----EFKF-LADEYNSVLLNPCHCKGACENSEVCAHGGQYEFTEDG 74

Human  3802 AEVHLRKSAFDMFNFLASKHRQPPEYNP----NDEEEEEVQLKSARRATSMDLPMPMRFRHLKKT 3862
            :|:.||.||                 ||    ||      ..|..|...|..|......:||:
  Fly    75 SELILRNSA-----------------NPVIECND------MCKCCRNTCSNRLVYSGPRKHLE-- 114

Human  3863 SKEAVGVYRSPIHG-RGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDS 3926
                  ::.||::| :||.....|..|..:.||||.::  ...:.|.:.:|::.:|...:.:..:
  Fly   115 ------IFDSPVYGSKGLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGLMNYILVLN 171

Human  3927 E----------VVDATMHGNAARFINHSCEPNCYSRVINIDGQ-KHIVIFAMRKIYRGEELTYDY 3980
            |          :||.:..||..|::||||||||:...:.||.. ..|.|||.|.|...|||.:.|
  Fly   172 EYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEELCFHY 236

Human  3981 --KFPIEDASNKLPCNCGAKKCRKFL 4004
              :...:..:....|.|||.||..|:
  Fly   237 GGEGQYKKMTGGKTCLCGASKCTGFM 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:366873
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163
		FYRN	2060..2107	CDD:461787
		FYRC	3705..3788	CDD:197781	6/30 (20%)
		SET_KMT2A_2B	3852..4005	CDD:380947	49/167 (29%)
CG4565	NP_001097743.1	SET_SETMAR	16..267	CDD:380942	75/286 (26%)