DRSC/TRiP Functional Genomics Resources

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Protein Alignment KMT2A and ash1

DIOPT Version :9

Sequence 1:XP_011541131.1 Gene:KMT2A / 4297 HGNCID:7132 Length:4005 Species:Homo sapiens
Sequence 2:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster


Alignment Length:1961 Identity:386/1961 - (19%)
Similarity:625/1961 - (31%) Gaps:649/1961 - (33%)


- Green bases have known domain annotations that are detailed below.


Human  2244 RIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQR---- 2304
            :::...|...:.|.|     ..|.:.||..|.:|       .:.|:|......|.:..|:.    
  Fly    12 KVLETQRAQESGSEN-----EETDSITDQSSQSK-------SIKSATQFSVQRSDTDGLRMRISA 64

Human  2305 ---TVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPK 2366
               |:..|..|........|::..:|..|:..:::.|   :|.||...|.:..|       ||  
  Fly    65 IRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVS---KKVKVKRKKLASSS-------GI-- 117

Human  2367 LAPQVHNTTSRELNVSKIGSFAEPSSVS-FSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPD 2430
                     |:...|||    ::.|.:| |||......| |.:..||..|...:...|:|.|:  
  Fly   118 ---------SKSDKVSK----SKKSQISAFSSDSEDDLP-LKVHQQRAPRVLLSAIIQAAQSA-- 166

Human  2431 EDTEVKTLKLSGMSNRSSIIN------EHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVT 2489
               ...||.:...|:.:.:.|      :.:.|.:.|...:|  |.::..|:|:..:         
  Fly   167 ---SKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEG--SFRKAAKDKNLPQ--------- 217

Human  2490 TGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKR 2554
              .:..|..:||::.   :.:||.....::.:|          |.||.    |.:..:...||||
  Fly   218 --YQSTLLQDFMEKT---QMLGQTVNAKLAEEK----------VAKAK----EETLVQTAVPRKR 263

Human  2555 TVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDS 2619
            ..:.......:.....|..|:.||:.:.  .|.:||.|:..:            |||.      .
  Fly   264 RGRPKKVVPTVPAPGNSGPAINESADSG--VISTTSTTQSTT------------PSPK------M 308

Human  2620 QSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFY 2684
            |:.|    .|...:|.:....||:.|.::..:                      |.|..|.: .|
  Fly   309 QNEN----AVPTGSLPIASSSKPKIDMAYLDK----------------------RMYATERV-LY 346

Human  2685 SSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPK 2749
            .....|:|                         .|..:|..||..:|.|....|:||   .|:.|
  Fly   347 PPPRSKRR-------------------------QNNKKTACSSSNKEELQLDPLWRE---IDVNK 383

Human  2750 ISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEP 2814
            ..:|..:..|..|.|. .:||..|..:..::|..:           |.|...| .:||..|.:..
  Fly   384 KFRLRSMSVGAASGTG-ASTTICSKVLAAKSGYVS-----------DYGSVRH-QRSSHNHNSGY 435

Human  2815 KMD-NCHS----------VSRVKTQG--QDSLEAQLSSLESSRRVHTS---------TPSDKNLL 2857
            |.| :|.|          .||.|:.|  .|..|:..|.|...|:...|         |..|:::|
  Fly   436 KSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDIL 500

Human  2858 DTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLN---------- 2912
            ......|.:|..::|              :::.|  ||:::|   |.:|:|:...          
  Fly   501 QLAGLSLGQSSEESN--------------EYISK--PSLKSL---PTTSASKKYGEINRYVTTGQ 546

Human  2913 -LGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVS---------------------------- 2948
             .|.| |..|....|..:.::.:|:..|..|..||..                            
  Fly   547 YFGRG-GSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRR 610

Human  2949 SSISAEEQFELPLELPSDLSVLTT------------------RSPTVPSQNPSRLAVISDSGEKR 2995
            .|.|..:...:..:|.:::.::|:                  :...:...|..:..:.:.|..::
  Fly   611 KSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQ 675

Human  2996 VTITEKSVASSESDP-----------------ALLSPGVDPTPEGHMTPDHFIQGHMDADHISSP 3043
            :|:.....||:.|.|                 |:||.....||.|                 |..
  Fly   676 LTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNG-----------------SGS 723

Human  3044 PCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLK 3108
            ..|:.::.|..:|  :.:||:|.     ...:|::.:.|:....:.| |::::.|          
  Fly   724 SNGNTKRRHKKSQ--SNDSSSPD-----DHKLPLKKRHYLLTPGERP-PAEVAFA---------- 770

Human  3109 PATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNP 3173
                                   ||........::.::..|...|.                   
  Fly   771 -----------------------NGKLNAEAWAAAAAAAKSTASTK------------------- 793

Human  3174 SLPTSQSLF--PSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPP-----------SGLLIGVQ 3225
                ||:.|  .|....|.|..  :||...|.:. |....:.||.|           .|.|:.: 
  Fly   794 ----SQAQFNARSVKSALTPKK--RHLLEQPTSV-SGAGSSASNSPLRIVVDNNSISGGKLLDI- 850

Human  3226 PPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTL 3290
               .|..|.|...||          ..|..|:.:|..     |.|....:|:...|...|     
  Fly   851 ---SPSSLCSLKQQR----------RGGAAKQKVSAA-----KDLVQLQSPAGSYPPPGV----- 892

Human  3291 INFTPS-----QLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAA 3350
              |.||     |:|       |..||.|       :|.:::..      :|||            
  Fly   893 --FEPSVELEIQIP-------LSKLNES-------VITKAEVE------SPLL------------ 923

Human  3351 GTSTISQDTS------------HLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLT-- 3401
            ....|.:||.            |.|.|::. |......:|.....|........||....|..  
  Fly   924 SALDIKEDTKKEVGQRVVETLLHKTGGNLL-LKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVID 987

Human  3402 --NPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICV 3464
              .|..  .||...:.:|....|..::.:|..|         .|.|...:.|.            
  Fly   988 EHEPEF--DPDDEPLQSLRETRSSNNVNVQAAP---------NPPLDCERVPQ------------ 1029

Human  3465 LPSTQTTGITAASPSGEADEHYQLQHVNQLL--ASKTGIHSSQRDLDSASGPQVSNFTQTVDAPN 3527
                          :|||.|.: :...||..  .|...:...||....|.|           .|.
  Fly  1030 --------------AGEARETF-VARTNQKAPRLSVVALERLQRPQTPARG-----------RPR 1068

Human  3528 SMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVP----GPTKPKPKTKR------FQLP 3582
            ....:..:...:|.|..|.|   .|....:.:|...|..|    .|..|.|:.|:      .:||
  Fly  1069 GRKPKNREQAEAAPQPPPKS---EPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLP 1130

Human  3583 --LDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAG 3645
              :|.......|:...|..:.||              ||              |..:::..||..
  Fly  1131 DGIDPNTNFSCKIRLKRRKNLEA--------------GT--------------QPKKEKPVQPVT 1167

Human  3646 QVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI-TEKKPKKGLVFEI 3709
            ...:.||:.|:|    |:..||                    .|.||.:|| ||..|........
  Fly  1168 VEEIPPEIPVSQ----EEIDAE--------------------AEAKRLDSIPTEHDPLPASESHN 1208

Human  3710 SSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLS-------FAGV--NGLRMLGILHDAVV- 3764
            .....:..|:||.||           ..|...|::||       .||:  |..:...:...|.| 
  Fly  1209 PGPQDYASCSESSED-----------KASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVN 1262

Human  3765 ---FLIEQLSGAK------HCRNYKFR----FHKPEE------------ANEPPLNPHGSARAEV 3804
               .|.||:..|.      :|..|..|    |..|.:            .|..|...:...|..|
  Fly  1263 KKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNV 1327

Human  3805 HLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARR-----ATSMDLPMPMRFRHLKKTSK 3864
            :......::..|      ..|..|..::.|:........|     .:..:.|...:.|: :|..:
  Fly  1328 YAESVRPNLAGF------DHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRN-QKIQR 1385

Human  3865 EAV--GVYR--SPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDD 3925
            .||  ||.|  :...|.|:..|..|..|..::||.|.|:...:..:|...........|...:|.
  Fly  1386 HAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDG 1450

Human  3926 SEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNK 3990
            ..|:|....|:..||:||||||||..:..:::|...:|:||.|.|..||||||||.|.:.:.|..
  Fly  1451 GLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEG 1515

Human  3991 LPCNCGAKKCR 4001
            .||.|...:||
  Fly  1516 QPCRCNTPQCR 1526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KMT2AXP_011541131.1 zf-CXXC 1180..1227 CDD:251032
PHD1_KMT2A 1466..1512 CDD:277063
PHD2_KMT2A 1514..1563 CDD:277065
PHD3_KMT2A 1601..1660 CDD:277067
Bromo_ALL-1 1683..1813 CDD:99925
ePHD_KMT2A 1907..2019 CDD:277163
FYRN 2061..2107 CDD:283589
FYRC 3705..3788 CDD:197781 23/105 (22%)
SET <3861..4005 CDD:225491 52/145 (36%)
SET 3867..3987 CDD:214614 44/123 (36%)
PostSET 3989..4005 CDD:214703 5/13 (38%)
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 7/48 (15%)
SET 1392..1512 CDD:214614 42/119 (35%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158009
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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