Protein Alignment KMT2A and egg

DIOPT Version :9

• Sequence 1: XP_011541131.1
• Gene: KMT2A / 4297
• HGNCID: 7132
• Length: 4005
• Species: Homo sapiens
• Sequence 2: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Alignment Length: 1694
• Identity: 296/1694 - (17%)
• Similarity: 508/1694 - (29%)
• Gaps: 658/1694 - (38%)

Human  2530 MPGVPKAPP-MQVEGSAKE--LQAPRKRTVKVTLTPLKMEN--ESQSKNALKESSPASPLQIEST 2589
            |.|.|.|.. ::..||..|  .:.|..|.....|...|.||  ||.::.|.|:      ::||..
  Fly     1 MSGQPTAVDCLESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQAAKD------VEIEEL 59

Human  2590 SPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPR 2654
            :.:|.|:|:     |...:..|.....                    ||.|....|.|..|:...
  Fly    60 THSEAIAAT-----GSTRKQCPYGGKA--------------------PDEPGKLADESEDRKGEN 99

Human  2655 RSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYN 2719
            ..|.|.|.:...:.....|... |..:.|.|::..:|...:.     |..::.:..:.:::
  Fly   100 TKAIASSPVLVAVDSDSSVELI-ESPVKFSSANESEKDPPKP-----DAVNEAAAKEAEEM---- 154

Human  2720 FTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKEN 2784
             |.:.|||...|.      |.|:::                       .|.:::.|.|.....:.
  Fly   155 -TDSSISSPTSES------FPEKDE-----------------------KTNKENEQEPPGMEVDQ 189

Human  2785 GTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVS-------RVKTQGQDSLEAQLSSLES 2842
            ..|. .|.||.:..:.|:..|   |||.         :|       ::..:..|.||.:|
  Fly   190 DVEE-SISRPAEEYKIENTLK---GHKR---------ISLTEIEEHKIVDKKDDVLEVEL----- 236

Human  2843 SRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDI-MDFVLKNTPSMQALGESPESS 2906
            .:........|:.|      ..|.||.|.....:|.|...:.: ..:||.|..::.......:||
  Fly   237 EKGTAPKAAEDEKL------NALLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKSS 295

Human  2907 SSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPV----------DSSVSSSISAEEQFELPL 2961
            ..:.|.:|       ..:..|.|:|.::.||...:|:          |.....|...||:.:.|.
  Fly   296 KQQFLCMG-------CHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDEEEEEKQPE 353

Human  2962 ELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMT 3026
            :  ||.|             .::|.:|.|                |.|.|:
  Fly   354 K--SDFS-------------KNKLQLIED----------------ELDDAI-------------- 373

Human  3027 PDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPG 3091
                                                                  |.|.|..|...
  Fly   374 ------------------------------------------------------KNVLNKVDFTA 384

Human  3092 PSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTS 3156
            ....|...:|....||:...                 .|.:...:|:|.|:.
  Fly   385 QLSWSKTILQAKADHLERQF-----------------ALADVELEKVQTTAD------------- 419

Human  3157 VLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLL 3221
                     .:...|..|.|.:                |:||            |.:...||..:
  Fly   420 ---------KMHCALYNSCPVA----------------HKHL------------PTLDIEPSDYV 447

Human  3222 IGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTR---KNKKLAPSSTPSNIAPSD 3283
            ..|.||.:                        :.:.||...:|.   |||.:|          |.
  Fly   448 HEVPPPGE------------------------IVRPPIQLGETYYAVKNKAIA----------SW 478

Human  3284 VVSNMTLINFTPSQLPNHPSL--LDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTA 3346
            |  ::.:|.||.|...|..::  ..:..||| .::.:..:   :...|.||||.|:
  Fly   479 V--SIKVIEFTESTAINGNTMKSYKIRYLNT-PYQMIKTV---TAKHIAYFEPPPV--------- 528

Human  3347 ATAAGTSTISQ-DTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSAS-----------VPGHVT 3399
            ....||..|:. |.:.|:.|...|:..|:....:::     .|...|:           ...:|.
  Fly   529 RLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIA-----EPLKQANRYRYLIFYDDGYTQYVP 588

Human  3400 LTNPRLLGT------PDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITA 3458
            ..:.||:..      .|:.:.|...|:...:...: |:|: :..:.|   |..|:::..|.....
  Fly   589 HRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYSV-DRPM-VQCTRG---QSMTTESNGTWLYAR 648

Human  3459 ASSI-CVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVS----- 3517
            ...| |.|...|.          |.|:::........|........:|.:::|:|..|:.
  Fly   649 VIDIDCSLVLMQF----------EGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRT 703

Human  3518 ----NFTQTVD------------APNSMGLEQNKALSSAVQASP-----TSPGG-SPSSPSSGQR 3560
                .:|:.::            |..|....||.||::|..|:.     |:.|| |.|:.:|..|
  Fly   704 EPFIRYTKEMESSSKVNQQMRAFARKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVR 768

Human  3561 SASPS---VPGPTKPKPK----TKRFQLPLDKGNGKKH--------KVSHLRTSSSEAHIPDQET 3610
            ..:.|   |....:||..    |.:..||  ....|.|        |:.|...|.|....|
  Fly   769 HLNNSTIYVDDENRPKGHVVYFTAKRNLP--PKMYKCHECSPNCLFKIVHRLDSYSPLAKP---- 827

Human  3611 TSLTSGTGTPGAEAEQQDTASVEQSSQKE------CGQPAGQVA-VLPEVQVTQNPAN------- 3661
              |.||          .:...:.|.::|.      ||:....:| |...::.|:|..|
  Fly   828 --LLSG----------WERLVMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFT 880

Human  3662 ------EQESAEPKTVEEE-----ESNFSSPLMLWLQQEQKRKESITEKK-PKKGLVFEISSDDG 3714
                  .:.|.:|..|::.     :...:.||:.:.........:..::: |.:|:  .::.|:.
  Fly   881 PDLKCLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGV--HLNLDEE 943

Human  3715 FQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNY 3779
            |.:|.:..:|.    :||     |.....||:.|||
  Fly   944 FLLCCDCEDDC----SDK-----SKCACWQLTVAGV----------------------------- 970

Human  3780 KFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSAR- 3843
              |:..|::    |:...|.....:|                    |:.|....|...:.|..:
  Fly   971 --RYCNPKK----PIEEIGYQYKRLH--------------------EHVPTGIYECNSRCKCKKN 1009

Human  3844 ---RATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQT- 3904
               |.....|.|.::             |:::...|.||.|..:|..|..:..|||:::.....
  Fly  1010 CLNRVVQFSLEMKLQ-------------VFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMAN 1061

Human  3905 ----DKREKYY-----------------------------DSKGIGC---------YMFR----- 3922
                |..::|:                             |:.|...         |.::
  Fly  1062 EGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKR 1126

Human  3923 ----------------IDDSE--------------------------------VVDATMHGNAAR 3939
                            :|..|                                ::||...||..|
  Fly  1127 SSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGR 1191

Human  3940 FINHSCEPNCYSRVINIDGQKH------IVIFAMRKIYRGEELTYDYKFPIEDASNK-LPCNCGA 3997
            :.||||.||.:.:.:.:|  .|      :..|:...|..|.|||::|.:.:.....| |.|.|||
  Fly  1192 YFNHSCSPNLFVQNVFVD--THDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGA 1254

Human  3998 KKCR 4001
            ..||
  Fly  1255 PNCR 1258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:251032
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163
		FYRN	2061..2107	CDD:283589
		FYRC	3705..3788	CDD:197781	14/82 (17%)
		SET	<3861..4005	CDD:225491	45/244 (18%)
		SET	3867..3987	CDD:214614	37/221 (17%)
		PostSET	3989..4005	CDD:214703	8/14 (57%)
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	13/71 (18%)
		Pre-SET	901..1013	CDD:282838	25/177 (14%)
		SET	1022..1239	CDD:214614	37/231 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930