DRSC/TRiP Functional Genomics Resources

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Protein Alignment KMT2A and Set2

DIOPT Version :9

Sequence 1:XP_011541131.1 Gene:KMT2A / 4297 HGNCID:7132 Length:4005 Species:Homo sapiens
Sequence 2:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster


Alignment Length:2052 Identity:381/2052 - (18%)
Similarity:637/2052 - (31%) Gaps:709/2052 - (34%)


- Green bases have known domain annotations that are detailed below.


Human  2155 PPSPDRPPHSQTSGSCYYHVISKVPRIRTPSY--SPTQRSPGCRPLPSAGSPTPTTHEIVTVGD- 2216
            |||...|..|:..|.      .:.|::...:.  :|...:|..:...:..|||....:.....: 
  Fly     6 PPSNPSPVASRGRGR------GRPPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSEC 64

Human  2217 ------PLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESS 2275
                  .::...:|.:.::......:   :.:.||.|...||::.|....:|.|           
  Fly    65 RRSSRKKIIKFDVRDLLNKNRKAHKI---QIEARIDSNPSTGHSQSGTTAASTS----------- 115

Human  2276 AKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSS---------ASD 2331
                      ::::|:...:.|:::.:.|..             |..||...|         |.:
  Fly   116 ----------MSTATASAASASSAATVSRLF-------------SMFEMSHQSLPPPPPPPTALE 157

Human  2332 LVSKSSSLKGEKTKVLSSKSSEGSAHNVAYP-----GIPKLAPQVHN--TTSRELNVSKIGSFAE 2389
            :.:|.   :..::.:::..:||.||...|:|     |:|.:.|:...  ..|:..:.:.|.:...
  Fly   158 IFAKP---RPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTVIV 219

Human  2390 PSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDED---------------TEVKTLK 2439
            ||.                    :|.|.::.||.::|.|.|..               ..:|.||
  Fly   220 PSC--------------------SDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLK 264

Human  2440 LSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEV 2504
            |.|....|...|....||..                       :||            |...|| 
  Fly   265 LGGRLESSDSGNSPSSSSPE-----------------------VEP------------PALQDE- 293

Human  2505 LTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENES 2569
               ..|.:||....:..::.|              ..|.|..:.|.            :.:|.|:
  Fly   294 ---NAMDERPKQEQNLSRMVD--------------AEENSDSDSQI------------IFIEIET 329

Human  2570 QSKNALKESSPASPLQIESTSPTEPIS-----ASENPGDGP----------VAQPSPNNTSCQDS 2619
            :|....:|.....|:::|   |.:.|.     |.:.|...|          |....|:..|. |.
  Fly   330 ESPKGEEEQEEGRPVEVE---PQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSA-DD 390

Human  2620 QSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFY 2684
            ::...::..||...   |.|.:|..|.....  ||||.|:        .||.|            
  Fly   391 EAEEEEDATVQRAT---PPGKEPAADSCSSA--PRRSRRS--------APLSG------------ 430

Human  2685 SSSTGKKRGKRSAEGQVDGADDLSTSDED----------DLYYYNFTRTVISSGGE---ERLASH 2736
            ||..||...:..||...:.:..:..::|.          ||.....:.:.::|...   |.:...
  Fly   431 SSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVE 495

Human  2737 NLFREEEQCDLPKISQLDGVDDG----------TESDTSVTATTRKSSQIPKRNGKENGTENLKI 2791
            .:..||.|.    :.:.|.:.|.          :||| ::.|:..|....||...|....|  .:
  Fly   496 EVVVEENQL----VDEADEILDSKQEFVIKKVFSESD-NIAASLNKDIFEPKVETKATCGE--VV 553

Human  2792 DRPEDAGEKEHVT--------KSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHT 2848
            .|||...|..::|        ||:|..|...:|     ::..|...:..:|..|......::...
  Fly   554 PRPEMVTEDVYITEGIAATLEKSAVVTKPTTEM-----IAETKLSDEVVIEPPLKDESDPKQTEV 613

Human  2849 STPSDKNLLDTYNTE-LLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLN 2912
            ..|..|..::...:| :|.::.:..:|.    ::|.:.......:.|.:.....|.|..|:|   
  Fly   614 ELPESKPAVNIPKSERILSAEVETTSSP----LVPPECCTLESVSGPVLLETSLSTEEKSNE--- 671

Human  2913 LGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSS----------------ISAEE------ 2955
                     |.|......|...:..|...|.:.:.:||                ::.:|      
  Fly   672 ---------NVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNN 727

Human  2956 -----QFELP-LELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLS 3014
                 |..|| ::.|......|........:||:|         ....|.:|.|.:.|.:..::.
  Fly   728 QKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPAR---------SSPAIVDKKVRAGEMEKKVVK 783

Human  3015 PGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSV------EQGHGNNQDLTRNSSTPGLQVPVSP 3073
            ......||..|.              |...|.:|      |.|....:.:.:..:          
  Fly   784 STKGTVPEKKMD--------------SKKSCAAVTPAKQKESGKSAKEAILKKET---------- 824

Human  3074 TVPIQNQK-------YVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLP 3131
                :.:|       ..||:.|..|..     ..|.:|.                     |||||
  Fly   825 ----EKEKSSAKLDSSSPNTLDKKGKD-----TAQWSPQ---------------------LQTLP 859

Human  3132 NGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQ 3196
            ...|:..|     .|.|||:...||               |...|..:.  .:|.|||...|...
  Fly   860 KSSTKPPQ-----ESAPSVISKTTS---------------NQPAPKEEQ--HAAKKGLSDNSPPS 902

Human  3197 HLHSFPAATQSSF------------------------------PPNISNPPSGLLIGVQPPPDPQ 3231
            .|.:...|. |.|                              |..:..||.     |:||    
  Fly   903 VLKAKEKAV-SGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPK-----VEPP---- 957

Human  3232 LLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPS 3296
                           .|.|..|.||....:...|:|                     |:...:|:
  Fly   958 ---------------TAVPVPGQKKSLSGKTSLRRN---------------------TVYEDSPN 986

Human  3297 QLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSH 3361
            ...|.....|....|||:.:..|:.:|:.           :.|:           .|||.:....
  Fly   987 LERNSSPSSDSAQANTSAGKLKPSKVKKK-----------INPR-----------RSTICEAAKD 1029

Human  3362 LTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSL 3426
            |.|.|    :||:....|.:....:|.:.|:|.......|...|    |.||      |..|:..
  Fly  1030 LRSSS----SSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDL----DGGS------KLDQRRY 1080

Human  3427 GIQD--QP---VALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHY 3486
            .|.:  ||   :.:|.:...|     |..|..:|         .|...|...||....|..:...
  Fly  1081 TICEDRQPETAIPVPLTKRRF-----SMHPKASA---------NPLHDTLLQTAGKKRGRKEGKE 1131

Human  3487 QLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGS 3551
            .|              |.|..|||:|..             |.|..:.|||.||...|       
  Fly  1132 SL--------------SRQNSLDSSSSA-------------SQGAPKKKALKSAEILS------- 1162

Human  3552 PSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSG 3616
                                                     .:.|.|.|||:      |:|    
  Fly  1163 -----------------------------------------AALLETESSES------TSS---- 1176

Human  3617 TGTPGAEAEQQDTASVEQSSQKECGQPAGQVA--------VLPEVQVTQNPANEQESAEPKTVEE 3673
                |::..:.|   |:.|.:.|...|.|.:|        :|...:|.::...|.:....:..:.
  Fly  1177 ----GSKMSRWD---VQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADP 1234

Human  3674 EESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQE--- 3735
            ||..|:..:............|.|:..|                     ||: .|.|..::|   
  Fly  1235 EEDEFAQRVANMETPATTPTPSPTQSNP---------------------EDS-ASTTTVLKELET 1277

Human  3736 ---ARSNARLKQLSFAGVNGLRMLGILHDAV--VFLIEQLSGAKHCRNYKFRFHKPEEANEPPLN 3795
               .|.:.|:||.. .|....:..|:...|:  :.:.|||:               |.||...:|
  Fly  1278 GGGVRRSHRIKQKP-QGPRASQGRGVASVALAPISMDEQLA---------------ELANIEAIN 1326

Human  3796 PHGSARAEVHLRKSAFDMFNFLASKH----RQPPEYNP--------NDEEEEEVQLKSARRATSM 3848
                   |..||....:.|..|....    ||..:.|.        ..:||.:..|.......:.
  Fly  1327 -------EQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINR 1384

Human  3849 DLPM---PMRFRHLKKTSKE-------AVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQ 3903
            .|.:   |:.....:.|:|.       ...|:|:...|.|:..:..|..||.::||.|.||.|.:
  Fly  1385 MLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEE 1449

Human  3904 TDKREKYYD-SKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAM 3967
            .::|:..|. .:....|...:....|:|||..||.:|:|||||:||..::...::|:..|..|::
  Fly  1450 FERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSV 1514

Human  3968 RKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFL 4004
            :.|..|||:|:||:: :....:...|.|.|..||.::
  Fly  1515 KPIQPGEEITFDYQY-LRYGRDAQRCYCEAANCRGWI 1550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KMT2AXP_011541131.1 zf-CXXC 1180..1227 CDD:251032
PHD1_KMT2A 1466..1512 CDD:277063
PHD2_KMT2A 1514..1563 CDD:277065
PHD3_KMT2A 1601..1660 CDD:277067
Bromo_ALL-1 1683..1813 CDD:99925
ePHD_KMT2A 1907..2019 CDD:277163
FYRN 2061..2107 CDD:283589
FYRC 3705..3788 CDD:197781 15/90 (17%)
SET <3861..4005 CDD:225491 47/152 (31%)
SET 3867..3987 CDD:214614 40/120 (33%)
PostSET 3989..4005 CDD:214703 5/16 (31%)
Set2NP_572888.2 AWS 1358..1410 CDD:197795 7/51 (14%)
SET 1414..1533 CDD:214614 40/119 (34%)
PostSET 1535..1551 CDD:214703 5/16 (31%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158003
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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