| Sequence 1: | XP_011541131.1 | Gene: | KMT2A / 4297 | HGNCID: | 7132 | Length: | 4005 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001259088.1 | Gene: | G9a / 30971 | FlyBaseID: | FBgn0040372 | Length: | 1657 | Species: | Drosophila melanogaster |
| Alignment Length: | 1882 | Identity: | 357/1882 - (18%) |
|---|---|---|---|
| Similarity: | 597/1882 - (31%) | Gaps: | 574/1882 - (30%) |
- Green bases have known domain annotations that are detailed below.
|
Human 2419 TDSTQSANSSPDEDT-------EVKTLKLSGMSNR--SSIINEHMGSSSRDRRQKGKKSCKETFK 2474
Human 2475 ----------------EKHSSKSFLEP-GQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDK 2522
Human 2523 IGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENES-----QSKNAL-KESSP- 2580
Human 2581 -----------------------ASPLQIESTS------PTEPISASENPGDGPVAQPSPNNTSC 2616
Human 2617 QDSQSNNYQNLPVQDRNLML-PDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEED 2680
Human 2681 IPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQC 2745
Human 2746 DLPKISQLDGVDDGTESDTSVTATTRKSSQIPK-RNGKENGTENLKIDRPEDAGEKEHVTKSSVG 2809
Human 2810 HKNEP-KMDNCHSVSRVKTQGQDSLEAQLSSLESSR-------RVHTSTPSDKNLLDTYNTELL- 2865
Human 2866 -KSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQ--ALGESP----ESSSSELLNLGEGLGLDSNR 2923
Human 2924 EKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVI 2988
Human 2989 SD--------SGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDH-----------FIQGH 3034
Human 3035 MDADHISS--------PPCGSVEQG----HGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYV---- 3083
Human 3084 --PNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSS 3146
Human 3147 --TPSVMETN-TSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSS 3208
Human 3209 FPP--NISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKR--------PISRLQ 3263
Human 3264 TRK----NKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNT--------SSHR 3316
Human 3317 TVPNIIKRSKSSIMY-------------FEPAPLLPQSVGGTAATAAGTSTISQDTSHLT----- 3363
Human 3364 ---SGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQS 3425
Human 3426 LGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGIT---AASPSGEA----- 3482
Human 3483 --DEHY-----QLQHVNQLLASKTGI-----------------HSSQRDL------DSASGPQVS 3517
Human 3518 NFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLP 3582
Human 3583 LDKGNGKKHKVSHLRTSSSEAHIPDQETTS--LTSGTGTPGAEAEQQDTASVEQSSQKECGQ-PA 3644
Human 3645 GQVAVLPE------------VQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESIT 3697
Human 3698 EKKPKKGLVFEISSDDGFQ----------ICAESIEDAWKSLTDKVQEARSNARLKQLSF----- 3747
Human 3748 --------AGVN---------GLRMLGILHDAVVFLIEQLSGAKHC------RNYKFRFHKPEEA 3789
Human 3790 NE---PP----------------------------LNPHGSARAEVHLRKSAFDMFNFLASKHRQ 3823
Human 3824 PPEYNPNDE----EEEEV----QLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLF 3880
Human 3881 CKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSC 3945
Human 3946 EPNCYSRVINIDGQKH----IVIFAMRKIYRGEELTYDY--KFPIEDASNKLPCNCGAKKCR 4001 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| KMT2A | XP_011541131.1 | zf-CXXC | 1180..1227 | CDD:251032 | |
| PHD1_KMT2A | 1466..1512 | CDD:277063 | |||
| PHD2_KMT2A | 1514..1563 | CDD:277065 | |||
| PHD3_KMT2A | 1601..1660 | CDD:277067 | |||
| Bromo_ALL-1 | 1683..1813 | CDD:99925 | |||
| ePHD_KMT2A | 1907..2019 | CDD:277163 | |||
| FYRN | 2061..2107 | CDD:283589 | |||
| FYRC | 3705..3788 | CDD:197781 | 18/120 (15%) | ||
| SET | <3861..4005 | CDD:225491 | 43/147 (29%) | ||
| SET | 3867..3987 | CDD:214614 | 39/125 (31%) | ||
| PostSET | 3989..4005 | CDD:214703 | 3/13 (23%) | ||
| G9a | NP_001259088.1 | ATP-synt_B | 150..248 | CDD:304375 | 24/121 (20%) |
| Ank_2 | 1056..1152 | CDD:289560 | 20/109 (18%) | ||
| ANK | 1088..1217 | CDD:238125 | 33/160 (21%) | ||
| ANK repeat | 1088..1120 | CDD:293786 | 6/34 (18%) | ||
| ANK repeat | 1124..1153 | CDD:293786 | 6/33 (18%) | ||
| Ank_2 | 1127..1249 | CDD:289560 | 29/149 (19%) | ||
| ANK | 1155..1306 | CDD:238125 | 30/169 (18%) | ||
| ANK repeat | 1155..1196 | CDD:293786 | 10/40 (25%) | ||
| ANK repeat | 1199..1249 | CDD:293786 | 11/57 (19%) | ||
| Ank_2 | 1205..1316 | CDD:289560 | 17/129 (13%) | ||
| ANK repeat | 1251..1283 | CDD:293786 | 4/38 (11%) | ||
| ANK repeat | 1285..1316 | CDD:293786 | 3/30 (10%) | ||
| PreSET | 1357..1466 | CDD:128744 | 18/120 (15%) | ||
| SET | 1495..1602 | CDD:214614 | 39/124 (31%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165158006 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.840 | |||||