DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KMT2A and set1

DIOPT Version :9

Sequence 1:	XP_011541131.1	Gene:	KMT2A / 4297	HGNCID:	7132	Length:	4005	Species:	Homo sapiens
Sequence 2:	NP_587812.1	Gene:	set1 / 2538762	PomBaseID:	SPCC306.04c	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	627	Identity:	172/627 - (27%)
Similarity:	259/627 - (41%)	Gaps:	161/627 - (25%)

- Green bases have known domain annotations that are detailed below.

Human  3416 NLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGIT------ 3474
            |||:    .|..:.|.|:.:..:.|..|.|     |.......:|.:.:...::|....
pombe   418 NLLV----SSTSVPDVPLKIESTVGKLPSL-----PKFKKRVDSSKMNLSAGSKTKSKLQRRRRR 473

Human  3475 --AASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKAL 3537
              .|.|.     ||||   ||:..|......|.::|..:||.:              .:|:.|.
pombe   474 RHEARPL-----HYQL---NQMYNSSASEAESDQELLLSSGDE--------------RVERGKI- 515

Human  3538 SSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSE 3602
                        ||..|..|.:  |:|.....:....|..||:........|..|:....|||||
pombe   516 ------------GSIKSVKSDE--ATPVFSDTSDENDKFHRFRTKSKISKKKYEKMEVDYTSSSE 566

Human  3603 AHIPDQETTSLTSGTGTPGAEAEQQDTASVEQ--SSQKECGQPAGQVAVLPEVQVTQNPANEQES 3665
            .    :...|:.|    |.|...:..:|..::  |.:||..:   .:|:.|:.::  |..:|..|
pombe   567 T----ESDASILS----PSAAIPKSGSAIKDELISPKKEIDE---VLALAPKWRI--NEFDETGS 618

Human  3666 ----AEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAW 3726
                |.|....|::      ::|.|.                ||.:.:.:|:.:....|:::|
pombe   619 VYYGALPYNYPEDD------VLLDLD----------------GLQYLVKNDEDYSYLQEALKD-- 659

Human  3727 KSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHC--RNYKFRFHKPEEA 3789
            :.|.|                           ::|...:..|:    |.|  :|...::......
pombe   660 EPLMD---------------------------INDPNFWAYER----KSCKFKNGDVKYGDTAIL 693

Human  3790 NEPP----LNPHGSARAE-------------VHLR-KSAFDMFNFLASKHRQPPEYNPNDEEEEE 3836
            .||.    .|..|||::|             :.|| :|..|..:.  |..|.....|..:.....
pombe   694 PEPKGYFRSNTSGSAKSEGYYIIPTTEKSLYLPLRNRSTIDTISH--STSRITSRMNRVNNRRLA 756

Human  3837 VQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSP--IHGRGLFCKRNIDAGEMVIEYAGNVI 3899
            ..::.::.....||   :||..||...|:   ::..|  ||..|||...|||..:|||||.|.:|
pombe   757 AGVEKSQLPAEADL---LRFNALKARKKQ---LHFGPSRIHTLGLFAMENIDKNDMVIEYIGEII 815

Human  3900 RSIQTDKREKYYDSKGIG-CYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIV 3963
            |....|.|||.|..:||| .|:||||:..:||||..||.||||||||.|||.:|:|.::|::.||
pombe   816 RQRVADNREKNYVREGIGDSYLFRIDEDVIVDATKKGNIARFINHSCAPNCIARIIRVEGKRKIV 880

Human  3964 IFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 4005
            |:|.|.|..|||||||||||.|  ::|:||.|||..||.:||
pombe   881 IYADRDIMHGEELTYDYKFPEE--ADKIPCLCGAPTCRGYLN 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:251032
		PHD1_KMT2A	1466..1512	CDD:277063
		PHD2_KMT2A	1514..1563	CDD:277065
		PHD3_KMT2A	1601..1660	CDD:277067
		Bromo_ALL-1	1683..1813	CDD:99925
		ePHD_KMT2A	1907..2019	CDD:277163
		FYRN	2061..2107	CDD:283589
		FYRC	3705..3788	CDD:197781	11/84 (13%)
		SET	<3861..4005	CDD:225491	77/146 (53%)
		SET	3867..3987	CDD:214614	68/122 (56%)
		PostSET	3989..4005	CDD:214703	8/15 (53%)
set1	NP_587812.1	RRM	<90..>226	CDD:223796
		RRM_spSet1p_like	96..180	CDD:240749
		SET_assoc	279..342	CDD:288600
		SET	457..920	CDD:225491	159/577 (28%)
		N-SET	641..771	CDD:288597	26/167 (16%)
		SET	783..899	CDD:214614	64/115 (56%)
		PostSET	904..920	CDD:214703	8/15 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870