Protein Alignment KMT2A and set-16

DIOPT Version :10

• Sequence 1: XP_011541131.1
• Gene: KMT2A / 4297
• HGNCID: 7132
• Length: 4005
• Species: Homo sapiens
• Sequence 2: NP_499819.3
• Gene: set-16 / 176802
• WormBaseID: WBGene00011729
• Length: 2475
• Species: Caenorhabditis elegans
• Alignment Length: 3346
• Identity: 613/3346 - (18%)
• Similarity: 985/3346 - (29%)
• Gaps: 1253/3346 - (37%)

Human  1023 CLSTPSSSTVK-------HSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTD 1080
            |:....|.|:.       ..:||.||    ..::...|.|..:..:|:....|
 Worm    20 CMDVNRSGTMSLDMARQCDMSSSCGS----CQRMITADSRQCTTCRKSYHLSC------------ 68

Human  1081 QPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDD-MPTLSALPWEEREKILSSMGND 1144
                     |||:.|.....:...||       |:..:.||| |.:.||.|         |.|.|
 Worm    69 ---------DSSDVSSLNNFVCISCR-------RRSQMLPDDVMLSASARP---------SRGQD 108

Human  1145 DKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVCTNCLDK 1209
                       .||:|...|..|....:....|......||:
 Worm   109 -----------APLSPFSDPSVPQISLQMQPAPLPSSYPRSQ----------------------- 139

Human  1210 PKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSS 1274
             .|.|....:.....::.|..|....:..|..||:.:.:......|:: .|...|...:...|..
 Worm   140 -DFNGDVYTQIAAMQQQRQQQQQNQVQQMLATQAQLMDEISDGGGTND-SDRNSSPFYQEASDYD 202

Human  1275 QKPTPSA-----REDPAPKK----------SSSEPPP-------------------RKPVEEKSE 1305
            :...|::     |...|.||          ..:.|.|                   .:|.:..|.
 Worm   203 EDFVPASTRGRGRGGGAKKKPGRGGSTGTRRQTNPGPSGFFSATQLQAMSGDFSHLHQPQQTSST 267

Human  1306 EG-------NVSAP-----GPESKQATTPASRKSSKQVSQPALV---------------IPPQPP 1343
            .|       ..|.|     ||...:.....|..:..|::|...|               :.|..|
 Worm   268 RGKRGKRGNGTSVPRQPGKGPGRGRGRGRGSAAAIAQLAQLQQVQYGAQGAPMFNGAPQLHPTQP 332

Human  1344 T---TGPPR---KEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVN 1402
            |   |.||.   :.|..|.|..|...|.|.|:            |.|||    .|..::.|..|.
 Worm   333 TVAPTLPPSVTYQNVAPTAPPAPPALQTPLPD------------PLPSI----VPSFQQAPQAVA 381

Human  1403 KQE-NAGTLNILSTLSNGNSSKQK---IPADGVHRIRVDF-KEDCEAENVWEMGGLGILTSVPIT 1462
            .:| :...|...|:..:|.|...:   |....|.|:..:| ::.|
 Worm   382 IREVDELMLEDESSRQSGGSRSDEPEYIRTAIVCRVNDEFLQKAC-------------------- 426

Human  1463 PRVVCFLCASSG---HVEFVYCQVCCEPFHKFCLEENERPLEDQLEN------WCCRRCKFCHVC 1518
               :|.:|.|.|   ....|.|..|.:.:|.:|:     .|.|:|.:      |.|..|..|..|
 Worm   427 ---MCLVCGSIGKGPEGSMVACSNCAQTYHTYCV-----TLHDKLNSAVVGRGWRCLDCTVCEGC 483

Human  1519 GRQHQATKQLLECNKCRNSYHPECLGP---NYPTKPTKKKKVWICTKCVRCKSCG-STTPGKGWD 1579
            |........|| |::|..|||..|:.|   ..|..|      |.|..|.||:.|. ....|....
 Worm   484 GTGGDEANLLL-CDECDVSYHIYCMKPLLDKIPQGP------WRCQWCSRCRRCNHKAASGNDLT 541

Human  1580 AQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYE 1644
            :|     .||..||.|    ..||.|::.|   ....|:::|.:|.:|.|..||.|. |::::
 Worm   542 SQ-----GLCFPCASL----RKCPRCERNY---QLNEKLIRCSQCSKWQHGACEGLY-TDEQL-- 591

Human  1645 ILSNLPESVAYTCVNCTERHPAE------------W--RLALEKELQISLKQVLTALLNSRTTSH 1695
                  |..|...:.|:...|..            |  .:||:|:....||...|.   |...:|
 Worm   592 ------EQAAIDRMRCSACRPKRVQPSGFSDVDTVWCDYVALDKDAHEILKSKYTP---SALKNH 647

Human  1696 LLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVL 1760
            ::                ||:..|.|.:..|          ||..||:
 Worm   648 MM----------------ESVGYRESFDHYD----------DDYNPLE----------------- 669

Human  1761 EFSDDIVKI-IQAAINSDGGQPEIKKANSMVKSFFIRQMERV-FPWFSVKKSRFWEPNKVSSNSG 1823
            :.||.:..: |........|.|..:           |.|.|: ...|..|..|    :::.:.:.
 Worm   670 DSSDQVTPLPIPGQRGRGRGNPSGR-----------RGMNRIGIGGFYAKLPR----HRIQALTE 719

Human  1824 MLPNAVLPPSLDHNYAQWQEREENSHTEQ--PPLMKKIIPAPKP-KGPGEPDSPTPLHPPTPPIL 1885
            ... |....|.|...|:...:...|..|.  ||.:::.....|. :|....|:|.
 Worm   720 EAA-AAAASSEDSKQAKRPRKSRRSQLEDAYPPQIQEAFFGIKAVEGKVLVDTPV---------- 773

Human  1886 STDRSREDSPELNPPPG----IEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTH-VNCALWSAE 1945
                   |.|.|....|    ....:...||:|..:....|      |.:||:.. |.......:
 Worm   774 -------DEPFLAEFNGWYKRTRSTKAFELCMTASEMLRTD------IDENEFLDCVGLPNMETD 825

Human  1946 VFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYC 2010
            ..:|.|.:|...........:|.......||                      |....:|.
 Worm   826 ALDDFDFNLLEDFDVDEENDELENSLLGAPG----------------------NTEMKEDA---- 864

Human  2011 QRHRDLIKGEVVPENGFEVFRRVFVDFEGISL--RRKFLNGLEPENIHMMIGSMTIDCLGILNDL 2073
               .:.|:|...| ..|.:.:|......|.||  :..|..|:.|.|...       ...|:.|.:
 Worm   865 ---AEGIEGSYGP-TSFNLDQRPSTSSAGGSLGSQDPFHPGMNPANFAQ-------HAPGVRNAI 918

Human  2074 SDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSF 2138
            :..               .|.||..:|..::.:                .|.||...:..:..:.
 Worm   919 ARS---------------GSQTDNSERYQFSAR----------------WEEDEPNGLQATTAAV 952

Human  2139 TESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVI--SKVPRIRTPSYSPTQRSPGCRPLP-- 2199
            ..|:.|......:.  |...||....|.......|.:  ..|.|.|     ..:...|.||.|
 Worm   953 LYSNEKHGYLRQQF--PNWVDRVKQIQKLWRTLNHEVRLDYVNRAR-----DNRTRSGNRPRPRR 1010

Human  2200 ----SAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTY----- 2255
                |..||.|.........:|  ||.:  :||   |..|:.|::..:....||.....|
 Worm  1011 TNVQSTDSPPPPQMGFKVPANP--SSNM--MGS---SEQSMQPKQVFITHHLPMDVYQVYQDLKR 1068

Human  2256 ---------------------SRNNVSS-----VSTTGTATDLESSAKVVDHVLGPLNSSTSLGQ 2294
                                 .:.|:::     |.|...|.|.:                   |:
 Worm  1069 VKFDRERLNGSLEEQLNKARKQKKNLAAKKRQMVKTQTAAPDYD-------------------GR 1114

Human  2295 NTSTSSNLQRTVVTVGNKNSHLDGSSSSEMK---------QSSASDLVSKSSSL------KGEKT 2344
            |...:.:.|:|:.|:..:..    .:.:|::         :|:.||.|.|...|      |.|..
 Worm  1115 NIDLNESDQQTLATLTEQIK----VTQAEIELHRRDLKKHESNLSDFVMKHGILRNEHEVKREDV 1175

Human  2345 KVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLR 2409
            ::.:.:..:.:||     ....||.|..|        ..:|....|  |..:.:.|:|.|.|:
 Worm  1176 QLSAIRDQQYAAH-----ADEMLAQQAQN--------QGLGQVHPP--VLVAPQAAISLPMLN-- 1223

Human  2410 GQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFK 2474
             |:....|.....|.....|.:      ..:.....:...||.|       ..:..|:...:.|:
 Worm  1224 -QQQQHHQRMMQMQMRGGPPGQ------FMMRAQPPQQPQINMH-------NHEIAKRMLMQQFR 1274

Human  2475 EKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEY---------------------MGQRPCNNV 2518
            ..|.....:...::|            |.::...|                     .||:|
 Worm  1275 NAHPVMGGIRHDEIT------------DPIMRDVYDCLEAIVFDVHTVAEREAMQAAGQQP---- 1323

Human  2519 SSDKIGDKGLSM-PGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPAS 2582
            ....|..:.:.. ||.|..|.:.:.|...:||..|                      :.:..|
 Worm  1324 PPPHIMQRMMQQHPGGPGGPRLIMPGQFPQLQGRR----------------------IPQQPP-- 1364

Human  2583 PLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGS 2647
            |:|:.......|.:|::....|  ..|..|.:|...:...:.....::.|..:.||.||.|::
 Worm  1365 PVQLPQVDVDPPKTAAKRKKGG--GNPKKNASSYPAAGEYDAWIEQMRMRFRLCPDIPKKQKE-- 1425

Human  2648 FKRRYPRRSARARSNMFFGL-----------TPLY----------GVRSYGEEDIPFYSSSTGKK 2691
                 ||.:......:..||           |||.          |.|.:|.|:
 Worm  1426 -----PRLNRPGCEFVSHGLTDMAVRATKKRTPLVGEFGAMRVKRGTRLFGNEE----------- 1474

Human  2692 RGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKI--SQLD 2754
            ||::|...|             ||                     ||::.|.|..|..:  :.|.
 Worm  1475 RGEKSIMFQ-------------DL---------------------NLYQVEPQIRLFALYNNPLP 1505

Human  2755 GVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNE----PK 2815
            .::|....|.......:.:|.:.|...|:.|.          :|..:|: :|...:..|    |.
 Worm  1506 TMEDDVFRDEEDQIIDKPTSALQKLLNKKRGA----------SGAMDHI-RSRARYMEETNIPPA 1559

Human  2816 MDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNT-ELLKSDSDNNNSDDCGN 2879
            .:.......|:.:.:.::|.                       .:|| ::.:..|.:...|.||.
 Worm  1560 PERGMFYENVEAEEEVTVEL-----------------------VFNTCDITEESSVDEKKDVCGR 1601

Human  2880 ILPSDIMDFV---------LKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQ 2935
             |...|.|.:         :::||.     |||.|.|
 Worm  1602 -LHEQIRDLLAIKDEVAWSMEDTPP-----ESPVSRS---------------------------- 1632

Human  2936 QLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITE 3000
              |..|....:|..:.|                  |:|:|:                    ..||
 Worm  1633 --PEPEATVGAVQQTSS------------------TSRAPS--------------------EATE 1657

Human  3001 KSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTP 3065
            :.:.....:.|
 Worm  1658 REIKREVEEEA------------------------------------------------------ 1668

Human  3066 GLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTL 3130
               .||:|.:    ::.:...:.|...||..|.
 Worm  1669 ---APVAPEI----KREIVEPSQSQNSSQCKNC-------------------------------- 1694

Human  3131 PNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHH 3195
                 ||  ...|.||| |::......|.....|..:||...|
 Worm  1695 -----QK--ALESHSST-SIVTVKAEKLNLAPTGSVVTTRAAP---------------------- 1729

Human  3196 QHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPIS 3260
                         .||.:...|.
 Worm  1730 -------------VPPGVPGAPG------------------------------------------ 1739

Human  3261 RLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRS 3325
                      ||      ||||:..:...|.:|.
 Worm  1740 ----------AP------IAPSEEKTKEELASFC------------------------------- 1757

Human  3326 KSSIMYFE-----PAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTT 3385
             |...|:|     .|||..:.|      ||....:|::..:.....:     :.:::..||....
 Worm  1758 -SKKCYYELASATRAPLTEEEV------AAAEQHVSEEVYNKLKQVL-----TENIVKAVSQGKK 1810

Human  3386 TTPTSSASVPGHVTLTNPR----LLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLG 3446
            ..|          .||:||    ::   |.|...|:.|......:|..:.|
 Worm  1811 PDP----------QLTSPRDTRCMM---DEGRRENVTIVPVASLIGAVEAP-------------- 1848

Human  3447 TSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLD-- 3509
             .:.||..|..||...    ...|..|      .::..:.|.||.:.:|:.|.|:......||
 Worm  1849 -KEAPSQRAAEAAEDW----KAYTKSI------WDSFVNIQQQHAHHILSPKIGVPHPPYHLDKR 1902

Human  3510 ------SASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPG 3568
                  .....:.:...:.:.......:..|.||.|| :......||..:...:..|:|..:...
 Worm  1903 ICVFCGGIGDGETTRCGRLISLTEFYWVHVNCALWSA-EVFENQTGGLTNVDRAVLRAAQTACDH 1966

Human  3569 PTKPKPKTKRFQLPLD---------KGNG----------KKH-KVSH---------LRTSSSEAH 3604
            ..:|....|..::...         :.||          |:| |||:         ||    ..:
 Worm  1967 CKRPGASVKCHKMNCGVNYHVLCAMQNNGFFIKDRTFICKQHEKVSNQAIVGRLDALR----RIY 2027

Human  3605 IPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPA--------- 3660
            :...|.|.||.                                    ..::|..|.
 Worm  2028 VKRDENTMLTR------------------------------------LFELTDGPTLCMRLGAFT 2056

Human  3661 -NEQESAEPKTVEEEE-------SNFSSPLMLWLQQEQKRK---ESITEKKPKKGLVFEISSDDG 3714
             .:..|..||.::...       :|:....:.|..:..:.:   |.|.|.:..:. :|.:.|.:.
 Worm  2057 FYKIGSITPKQLKRFHTKDYIFPNNYRITRLFWSPKSHRERMMFECIIEDRNNQP-IFVVKSLED 2120

Human  3715 FQIC--AESIEDAWKSLTDKVQEARSNARLKQLSFAG--VNGLRMLGILHDAVVFLIEQLSGAKH 3775
            ..||  |.|...||:.:.:||.:.|...:...|.|.|  :.|..:.|:..:|:..:.|.|.|...
 Worm  2121 PTICYKAVSASKAWQPIYEKVHQLREQQQGDSLKFFGSQICGETLFGLNENAITKITESLPGFDT 2185

Human  3776 CRNYKFRFHKPEEANEPPL--NPHGSARAE-------VHLR------------------------ 3807
            ...|:.| |:.....|.||  |..|.||||       .|.|
 Worm  2186 IFTYQHR-HQNSPVLELPLAENLMGCARAEPRNRTIGQHFRTKPQPMGGTHHHIGSASGLSSQAT 2249

Human  3808 ---KSAFDMFNFLASKHRQPPEYNPNDEEEEEVQL----KSARRATSMDLPMPM----------- 3854
               .|:......|.|:.......:.|......|:.    ::|.||.:..:|..|
 Worm  2250 IIASSSSSANESLQSRQAATSVTSANSGRTRGVRSYYTEEAAARARAFGIPPEMASLSLRMETTQ 2314

Human  3855 -------RFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYD 3912
                   .::.:::..|:.|.:.||.|.|.||:.|.:|..|:.:|||.|.:|||...:.||..|.
 Worm  2315 NAQTAFSAYQKMRREWKDRVYLARSRIAGLGLYAKVDISMGDFIIEYKGEIIRSEVCEVREIRYV 2379

Human  3913 SKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDG---QKHIVIFAMRKIYRGE 3974
            ::..|.||||||:..|:||||.|..||:|||||:|||.:::::...   :|.|:|.|.|.|...|
 Worm  2380 AQNRGVYMFRIDEEWVIDATMAGGPARYINHSCDPNCSTQILDAGSGAREKKIIITANRPISANE 2444

Human  3975 ELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 4005
            ||||||:|.:|..::|:||.|||..|.|::|
 Worm  2445 ELTYDYQFELEGTTDKIPCLCGAPNCVKWMN 2475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:366873	4/46 (9%)
		PHD1_KMT2A	1466..1512	CDD:277063	14/54 (26%)
		PHD2_KMT2A	1514..1563	CDD:277065	16/51 (31%)
		PHD3_KMT2A	1601..1660	CDD:277067	15/58 (26%)
		Bromo_ALL-1	1683..1813	CDD:99925	23/131 (18%)
		ePHD_KMT2A	1907..2019	CDD:277163	17/112 (15%)
		FYRN	2060..2107	CDD:461787	6/46 (13%)
		FYRC	3705..3788	CDD:197781	23/86 (27%)
		SET_KMT2A_2B	3852..4005	CDD:380947	68/173 (39%)
set-16	NP_499819.3	PHD_SF	42..84	CDD:276966	11/66 (17%)
		PHD4_KMT2C_like	427..477	CDD:276987	14/54 (26%)
		PHD5_KMT2C_like	479..524	CDD:276988	16/51 (31%)
		PHD6_KMT2C_like	554..604	CDD:276989	16/61 (26%)
		HMG_KMT2C-like	936..1002	CDD:438813	13/88 (15%)
		ePHD2_KMT2C_like	1904..2008	CDD:277136	14/104 (13%)
		FYRN	2053..2104	CDD:461787	6/50 (12%)
		FYRC	2112..2199	CDD:197781	23/87 (26%)
		SET_KMT2C_2D	2319..2474	CDD:380948	67/154 (44%)