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Protein Alignment CAH4 and CA2

DIOPT Version :9

Sequence 1:	NP_651298.1	Gene:	CAH4 / 42965	FlyBaseID:	FBgn0039235	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_000058.1	Gene:	CA2 / 760	HGNCID:	1373	Length:	260	Species:	Homo sapiens

Alignment Length:	287	Identity:	80/287 - (27%)
Similarity:	117/287 - (40%)	Gaps:	60/287 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 HFGFNYDKQGRDWN----VKCGERQSPIALWSCNAITCNV-PKLKFLNYHKSLCDPLSVINNG-- 75
            |:|:........|:    :..||||||:.:   :..|... |.||.|:........|.::|||
Human     4 HWGYGKHNGPEHWHKDFPIAKGERQSPVDI---DTHTAKYDPSLKPLSVSYDQATSLRILNNGHA 65

  Fly    76 ----------LTVLMRIPKTVDGSRPSLCISTEGQQVFEADQLHFHWGSALSKGSEHCLDGNYYD 130
                      ..||...|  :||:             :...|.||||||...:||||.:|...|.
Human    66 FNVEFDDSQDKAVLKGGP--LDGT-------------YRLIQFHFHWGSLDGQGSEHTVDKKKYA 115

  Fly   131 GEVHIVHKNASYKSNKEAGLQPNGFAVLALFIRNLEDPNIETPAMNMICKQVSSITKLDDSCPLE 195
            .|:|:||.|..|....:|..||:|.|||.:|::    .....|.:..:...:.||.....|..
Human   116 AELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLK----VGSAKPGLQKVVDVLDSIKTKGKSAD-- 174

  Fly   196 DSMALQDLFASID-------SQKYFTYQGSLTTPPCAEAVIWFVFPTPLDVPKELWKHFWQL--- 250
                    |.:.|       |..|:||.|||||||..|.|.|.|...|:.|..|....|.:|
Human   175 --------FTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFN 231

  Fly   251 -RDSRDQRVLNTYRELQDGHDRPVYRS 276
             ....::.:::.:|..|...:|.:..|
Human   232 GEGEPEELMVDNWRPAQPLKNRQIKAS 258

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.