DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH4 and ca4b

DIOPT Version :9

Sequence 1:	NP_651298.1	Gene:	CAH4 / 42965	FlyBaseID:	FBgn0039235	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_001159683.1	Gene:	ca4b / 553246	ZFINID:	ZDB-GENE-080815-5	Length:	304	Species:	Danio rerio

Alignment Length:	257	Identity:	87/257 - (33%)
Similarity:	132/257 - (51%)	Gaps:	21/257 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DW---NVKCG-ERQSPIALWSCNAIT-CNVPKLKFLNYHKSLCDPLSVINNGLTVLMRIP--KTV 86
            ||   ...|| .:||||.:.:..|.| ..:..::|.:|.:.|  ...::|||.||.:.:|  ..:
Zfish    39 DWATVAAACGNNKQSPINIVTNKASTDSRLTPVQFTDYQERL--NAVIVNNGHTVQINLPDRAKI 101

  Fly    87 DGSRPSLCISTEGQQVFEADQLHFHWGSALSKGSEHCLDGNYYDGEVHIVHKNASYKSNKEAGLQ 151
            :|:...        ..::|.|||.|||.....||||.:||..:..|:|:||....|.|.::|...
Zfish   102 NGANLG--------STYKAQQLHLHWGKNGGPGSEHTIDGEKFPMELHVVHIKEEYNSLEQAVGD 158

  Fly   152 PNGFAVLALFIRNLEDPNIETPAMNMICKQVSSITKLDDSCPLEDSMALQDLFASIDSQKYFTYQ 216
            .:|.|||..|....|:.|....|   |...:::||..:.:..| .:::|..|..:.|..|||.|:
Zfish   159 SSGVAVLGFFYEESENANKNYDA---IINSLTNITHPESNAEL-GAISLDMLIPNEDLDKYFRYE 219

  Fly   217 GSLTTPPCAEAVIWFVFPTPLDVPKELWKHFWQLRDSRDQRVLNTYRELQDGHDRPVYRSKA 278
            ||||||.|||||:|.:|...:.:.||....|..|..|....::||:|.:|...|||||.|::
Zfish   220 GSLTTPGCAEAVVWTIFEKTIPLSKEQLSAFSNLTFSDGAAMVNTFRPIQLRFDRPVYYSRS 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH4	NP_651298.1	alpha_CA	35..274	CDD:238200	81/242 (33%)
ca4b	NP_001159683.1	alpha_CA_IV_XV_like	50..278	CDD:239391	81/241 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm6335
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.810