DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH4 and CAH2

DIOPT Version :9

Sequence 1:	NP_651298.1	Gene:	CAH4 / 42965	FlyBaseID:	FBgn0039235	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster

Alignment Length:	265	Identity:	82/265 - (30%)
Similarity:	138/265 - (52%)	Gaps:	14/265 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FGFNYDKQGRDWN---VKC-GERQSPIALWSCNAITCNVPKLKFLNYHKSLCDPLSVINNGLTVL 79
            ||:........|:   .:| |:.||||.:...:|:....|||:|.|: |.:.|.|.:.|||.|||
  Fly    28 FGYEGRHGPEHWSEDYARCSGKHQSPINIDQVSAVEKKFPKLEFFNF-KVVPDNLQMTNNGHTVL 91

  Fly    80 MRIPKTVDGSRPSL---CISTEGQQVFEADQLHFHWGSALSKGSEHCLDGNYYDGEVHIVHKNAS 141
            :::....| ..||:   .::.:....::.:|.|||||...:.|||..::...|..|:|:|.:|..
  Fly    92 VKMSYNED-EIPSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHVVLRNLE 155

  Fly   142 YKSNKEAGLQPNGFAVLALFIRNLEDPNIETPAMNMICKQVSSITKLDDSCPLEDSMALQDLFAS 206
            |.....|..:.:|.||:|.|.: :.|.:  |.........:|.|.:...|..:.:.:.|.: :.|
  Fly   156 YPDFASALDKDHGIAVMAFFFQ-VGDKS--TGGYEGFTNLLSQIDRKGKSVNMTNPLPLGE-YIS 216

  Fly   207 IDSQKYFTYQGSLTTPPCAEAVIWFVFPTPLDVPKELWKHFWQLRDSRDQRVLNTYRELQDGHDR 271
            ...:.||:|.||||||||:|.|.|..|.||:|:.::....| :|..:.|..:.|.:|.:|..:||
  Fly   217 KSVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAF-RLLTANDDHLKNNFRPIQPLNDR 280

  Fly   272 PVYRS 276
            .:|::
  Fly   281 TLYKN 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH4	NP_651298.1	alpha_CA	35..274	CDD:238200	77/241 (32%)
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	80/259 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG3338
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I2251
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113047at6656
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm1014
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
	9	8.970