DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH4 and ca6

DIOPT Version :9

Sequence 1:	NP_651298.1	Gene:	CAH4 / 42965	FlyBaseID:	FBgn0039235	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	XP_009295179.1	Gene:	ca6 / 100006448	ZFINID:	ZDB-GENE-030131-7091	Length:	538	Species:	Danio rerio

Alignment Length:	291	Identity:	85/291 - (29%)
Similarity:	147/291 - (50%)	Gaps:	41/291 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLVARSFAPINSGT-RSHFGFNYDKQGRDWNVK---C-GERQSPIAL------WSCNAITCNVP 54
            :|:.:.:||  ::|. ..::.::.:...:.|..|   | |::||||.:      :|        |
Zfish     9 LFVTSLNFA--SAGVDGDYWTYSGELDQKHWAEKYHDCGGQQQSPIDIQRRKVRYS--------P 63

  Fly    55 KLKFLNY--HKSLCDPLSVINNGLTVLMRIPKTVDGSRPSLCISTEG-QQVFEADQLHFHWG--S 114
            :::.|..  ::.:.....:.|||.:|.:::|.|:.        .|:| ...:.|.|:|.|||  .
Zfish    64 RMQQLELTGYEDIRGSFLMKNNGHSVEIQLPSTMK--------ITKGFPHQYTAVQMHLHWGGWD 120

  Fly   115 ALSKGSEHCLDGNYYDGEVHIVHKNA-SYKSNKEAGLQPNGFAVLALFIRNLEDPNIETPAMNMI 178
            ..:.||||.:||..|..|:|:||.|: .|.|.:||..:|:|.||||.|   .||.:.|....:..
Zfish   121 LEASGSEHTMDGIRYMAELHVVHYNSEKYPSFEEAKNKPDGLAVLAFF---FEDGHFENTYYSDF 182

  Fly   179 CKQVSSITKLDDSCPLEDSMALQDLFASIDSQKYFTYQGSLTTPPCAEAVIWFVFPTPLDVP-KE 242
            ...:::|..:..|..:.:...|..|  |.:...::.|:||||||||.|:|:|.||.||:.:. .:
Zfish   183 ISNLANIKYVGQSMSISNLNVLSML--SENLSHFYRYKGSLTTPPCFESVMWTVFDTPITLSHNQ 245

  Fly   243 LWKHFWQLRDSRDQRVLNTYRELQDGHDRPV 273
            :.|....|.|..::.:.|.||..|..::|.|
Zfish   246 IRKLESTLMDHDNKTLWNDYRMAQPLNERVV 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH4	NP_651298.1	alpha_CA	35..274	CDD:238200	78/252 (31%)
ca6	XP_009295179.1	alpha_CA	33..281	CDD:320708	81/265 (31%)
ca6	XP_009295179.1	LamG	332..521	CDD:328935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750