DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nct and Ncstn

DIOPT Version :9

Sequence 1:	NP_001262932.1	Gene:	Nct / 42964	FlyBaseID:	FBgn0039234	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_067620.3	Gene:	Ncstn / 59287	MGIID:	1891700	Length:	708	Species:	Mus musculus

Alignment Length:	720	Identity:	225/720 - (31%)
Similarity:	352/720 - (48%)	Gaps:	87/720 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLILSYGATIA---QGERTRDKMYEPIG-GASCFRRLNGTHQTGCSSTYSGSVGVLHLINVEADL 72
            ||:||:...:|   .|.....|:|.|:. .|.|.|.||.|||.||.|:.||..||:|::..|.||
Mouse    17 LLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDL 81

  Fly    73 EFLLSSPPSPPYAPMIPPHLFTRNNLMRLKEAGPKNISVVLLINRTNQMKQFSHELNCPNQYSGL 137
            :::|:..|:|||..::...||||:.:.:||....:...:.:.:.:.|....||..:.|||...|:
Mouse    82 KWVLTDGPNPPYMVLLEGKLFTRDVMEKLKGTTSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGI 146

  Fly   138 NSTSETCDASNPAKN-WNPWGTGLLHEDFPFPIYYIADLDQVTKLEKCFQDFNNHNYETHALRSL 201
            .|.|...:.::..|. ||..|.||.:|||.|||:.:.|.::...:::|:||.|.....:.....|
Mouse   147 YSNSYGPEFAHCKKTLWNELGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPL 211

  Fly   202 CAVEVKSFMSAAVNTEVCMRRTNFIN---NLGGSKYCDPLEGRNVYATLYPRKPAIENNLETVHT 263
            ||:::.|.|.|.::|..|||| :||.   ::.....||||...||::.|.|...::  .||   .
Mouse   212 CAMQLFSHMHAVISTATCMRR-SFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSV--GLE---P 270

  Fly   264 NEKFILVTCRLDTTTMFDGVGLGAMDSLMGFAVFTHVAYLLKQLLPPQSKDLHNVLFVTFNGESY 328
            :.:.::...|||:.:.|..|..||..::..|......|..|.: .|..:....||:||.|.||::
Mouse   271 DVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHK-APDVTTLSRNVMFVFFQGETF 334

  Fly   329 DYIGSQRFVYDMEKLQFPTESTGTPPIAFDNIDFMLDIG--TLDDISNIKLH----ALNGTTLAQ 387
            |||||.|.|||||..:|        |:..:|||..:::|  .|....::.:|    :....::..
Mouse   335 DYIGSSRMVYDMENGKF--------PVRLENIDSFVELGQVALRTSLDLWMHTDPMSQKNESVKN 391

  Fly   388 QILERLNNYAKS----PRYGFNLNIQSEMSAHLPPTSAQSFLRRDPNFNALIL---NARPTNKYY 445
            |:.:.|....||    |........||:.   |||:|.|.|||. .|.:.::|   :....|:||
Mouse   392 QVEDLLATLEKSGAGVPEVVLRRLAQSQA---LPPSSLQRFLRA-RNISGVVLADHSGSFHNRYY 452

  Fly   446 HSIYDDADNVDFTYANTSKDFTQLTEVND-FKSLNPDSLQMKVRNVSSIVAMALYQTITGKEYTG 509
            .||||.|:|::.||.........|..|.| .|:|         .||::::|.|||:...|..::.
Mouse   453 QSIYDTAENINVTYPEWQSPEEDLNFVTDTAKAL---------ANVATVLARALYELAGGTNFSS 508

  Fly   510 TKVANPLMADEFLYCFLQSADCPLFKA------ASYPGSQLTNLPPMRYISVLGGSQESSGYTYR 568
            :..|:|......||.||..|:...|::      .||    |.:.|...||:|    ...:..||
Mouse   509 SIQADPQTVTRLLYGFLVRANNSWFQSILKHDLRSY----LDDRPLQHYIAV----SSPTNTTY- 564

  Fly   569 LLGYLLSQL---QPDIHRDNCTD---LP-----LHYFAGF---------NNIGECRLTTQNYSHA 613
            ::.|.|:.|   ..::.|:.|.|   :|     |:.::..         ..:.:|..:|...:.|
Mouse   565 VVQYALANLTGKATNLTREQCQDPSKVPNESKDLYEYSWVQGPWNSNRTERLPQCVRSTVRLARA 629

  Fly   614 LSPAFLIDGYDWSSGMYSTWTESTWSQFSARIFLRPSNVHQVTTLSVGIVVLIISFCLVYIISSR 678
            |||||.:.  .|||..||||.||.|....|||||..|...:..||.||...|:.|..:.|.|:::
Mouse   630 LSPAFELS--QWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSTLVFSLIVTYCINAK 692

  Fly   679 SEVLF 683
            ::|||
Mouse   693 ADVLF 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nct	NP_001262932.1	M28_Nicastrin	164..471	CDD:193502	99/322 (31%)
Ncstn	NP_067620.3	M28_Nicastrin	174..481	CDD:193502	100/325 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842759
Domainoid	1	1.000	121	1.000	Domainoid score	I5720
eggNOG	1	0.900	-	-		E1_KOG2657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41029
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2751
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54418
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005662
OrthoInspector	1	1.000	-	-		oto93525
orthoMCL	1	0.900	-	-		OOG6_104690
Panther	1	1.100	-	-	LDO	PTHR21092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2986
SonicParanoid	1	1.000	-	-		X4637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790