DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nct and ncstn

DIOPT Version :9

Sequence 1:	NP_001262932.1	Gene:	Nct / 42964	FlyBaseID:	FBgn0039234	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001009556.1	Gene:	ncstn / 494449	ZFINID:	ZDB-GENE-050131-1	Length:	707	Species:	Danio rerio

Alignment Length:	750	Identity:	228/750 - (30%)
Similarity:	362/750 - (48%)	Gaps:	99/750 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEMRLNAASIWLLILSYGATIAQGERTRDKMYEPIG-GASCFRRLNGTHQTGCSSTYSGSVGVLH 64
            ||..::...:.|||.:...|.........|:|..:. .|.|.|.||.|||.||.|:.||..||:|
Zfish     1 MENLISINCVQLLITALFYTCISCSSVEQKIYVELNKTAPCVRLLNATHQIGCQSSISGDTGVVH 65

  Fly    65 LINVEADLEFLLSSPPSPPYAPMIPPHLFTRNNLMRLKEAGPKNISVVLLINRTNQMKQFSHELN 129
            ::..|:||:::||:.|.|||..::....|.|:.::.:|.:. :...|.::|::....:.||....
Zfish    66 VLESESDLDWILSAGPHPPYMVIMETAFFNRSVMLSMKNSS-RVAGVAVIISKAGLAEHFSPHTT 129

  Fly   130 CPNQYSGLNST-SETCDASNPAKNWNPWGTGLLHEDFPFPIYYIADLDQVTKLEKCFQDFNNHNY 193
            ||||.:|:.|. ||..:.:...  |||.|.||.:|||.||::.:.|.:|...:.||::|.|....
Zfish   130 CPNQNTGVYSAGSEFANCNGTV--WNPLGNGLSYEDFTFPVFALKDENQTQVIRKCYEDHNLRVN 192

  Fly   194 ETHALRSLCAVEVKSFMSAAVNTEVCMRRTNFIN--NLGGSKYCDPLEGRNVYATLYPRKPAIEN 256
            .:.....|||:::.|.|.|..:|..|||||:..|  ::.....||||...||:.::.|...:...
Zfish   193 GSAPQYPLCAMQLFSHMHAVTDTVTCMRRTDLQNKFSINPEILCDPLSDYNVWTSIRPLNNSARG 257

  Fly   257 NLETVHTNEKFILVTCRLDTTTMF---DGVGLGAMDSLMGFAVFTHVAYLLKQLLPPQSKDLHNV 318
            :.|    ||..::...|||..:.|   .....|.:.:::......|..|.:.|..||    |.|:
Zfish   258 HAE----NESVVIAAVRLDGRSFFWEEAPAAEGTVSAIVTLLAAIHALYPVIQEAPP----LRNI 314

  Fly   319 LFVTFNGESYDYIGSQRFVYDMEKLQFPTESTGTPPIAFDNIDFMLDIGTL------------DD 371
            .|..|.||::|||||.|.|:|||:.||..:        .||:..||:||.:            |.
Zfish   315 FFTFFQGEAFDYIGSSRMVFDMERNQFVMD--------LDNVHSMLEIGQVGLRGGRDVWIHSDP 371

  Fly   372 ISNIKLHALNGTTLAQQILERLNNYAKSPRYGFNLNIQS-EMSAHLPPTSAQSFLRRDPNFNALI 435
            :|.      ..:::.:|:.|.:.: ..|...|.|:|:|. .:|..|||:|.|.|||..| ...|:
Zfish   372 VSR------RNSSMEKQVSEMIKD-VNSSAAGLNINLQEPSVSQPLPPSSFQRFLRVRP-IPGLV 428

  Fly   436 LNARP---TNKYYHSIYDDADNVDFTYANTSKDFTQLTEVNDFKSLNPDSLQMKVRNVSSIVAMA 497
            |....   .|:||.|:||||:|::.:|.      ..||.  |.:.:.|......:..|:::||.:
Zfish   429 LTDHEKAFNNRYYESMYDDAENLNVSYP------PNLTP--DEQLVYPTDAAKSLAEVATLVARS 485

  Fly   498 LYQTITGKEYTGTKV-ANPLMADEFLYCFLQSADCPLFKAASYP-------GSQLTNLPPMRYIS 554
            ||....|::...:.: |:..|..:.||.||...:...|::...|       .|.|::.||..||.
Zfish   486 LYTQAGGEQNNLSNITADATMVSQLLYGFLVQKNNSWFRSLLPPEITKKGGSSILSSGPPQFYIG 550

  Fly   555 VLGGSQESSGYTYRL-LGYLLSQLQPDIHRDNCT---------------DLPLHYFAGFNNIGE- 602
             ||...:|..::..| :.|:|:.|..::  .|.|               ||..:::....:.|.
Zfish   551 -LGPRLQSPVHSVTLFVQYILANLTGNV--TNLTESQCQNPKELSGENKDLYSYFWVSGPSSGNS 612

  Fly   603 -----CRLTTQNYSHALSPAFLIDGYDWSSGMYSTWTESTWSQFSARIFLRPSNVHQVTTLSVGI 662
                 |...:...|.|:||||.:  ..:.|..|||||||.|....|||||..|...::.||.||:
Zfish   613 SADPLCVRASVRLSKAVSPAFEL--LQYGSSDYSTWTESRWKSIRARIFLVASRELEMLTLGVGV 675

  Fly   663 VVLIISFCLVYIISSRSEVLFEDLPASNAASPRPT 697
            .||::|..:.|.|||::|:||      ::|...||
Zfish   676 AVLLLSLLVTYFISSKAELLF------SSARETPT 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nct	NP_001262932.1	M28_Nicastrin	164..471	CDD:193502	99/327 (30%)
ncstn	NP_001009556.1	M28_Nicastrin	163..470	CDD:193502	102/338 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41029
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D280914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010