Protein Alignment Nct and Ncstn

DIOPT Version :10

• Sequence 1: NP_001262932.1
• Gene: Nct / 42964
• FlyBaseID: FBgn0039234
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_777353.1
• Gene: Ncstn / 289231
• RGDID: 631418
• Length: 708
• Species: Rattus norvegicus
• Alignment Length: 719
• Identity: 219/719 - (30%)
• Similarity: 353/719 - (49%)
• Gaps: 85/719 - (11%)

  Fly    12 LLILSYGATIA---QGERTRDKMYEPIG-GASCFRRLNGTHQTGCSSTYSGSVGVLHLINVEADL 72
            ||:||:...:|   .|.....|:|.|:. .|.|.|.||.|||.||.|:.||..||:|::..|.||
  Rat    17 LLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEDDL 81

  Fly    73 EFLLSSPPSPPYAPMIPPHLFTRNNLMRLKEAGPKNISVVLLINRTNQMKQFSHELNCPNQYSGL 137
            :::|:..|:|||..::...||||:.:.:||....:...:.:.:.:.|....||..:.|||...|:
  Rat    82 KWVLTDGPNPPYMVLLEGKLFTRDIMEKLKGETSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGI 146

  Fly   138 NSTSETCDASNPAKN-WNPWGTGLLHEDFPFPIYYIADLDQVTKLEKCFQDFNNHNYETHALRSL 201
            .|.|...:.::..|. ||..|.||.::||.|||:.:.|.::...:::|:||.|.....:.....|
  Rat   147 YSNSYGPEFAHCKKTLWNELGNGLAYDDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPL 211

  Fly   202 CAVEVKSFMSAAVNTEVCMRRTNFIN---NLGGSKYCDPLEGRNVYATLYPRKPAIENNLETVHT 263
            ||:::.|.|.|.::|..|||| :||.   ::.....||||...||::.|.|     .|....:..
  Rat   212 CAMQLFSHMHAVISTATCMRR-SFIQSTFSINPEIVCDPLSDYNVWSMLKP-----INTSGGLEP 270

  Fly   264 NEKFILVTCRLDTTTMFDGVGLGAMDSLMGFAVFTHVAYLLKQLLPPQSKDLHNVLFVTFNGESY 328
            :.:.::...|||:.:.|..|..||..::..|......|..|.: .|..:....||:||.|.||::
  Rat   271 DVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHK-APDVTTLPRNVMFVFFQGETF 334

  Fly   329 DYIGSQRFVYDMEKLQFPTESTGTPPIAFDNIDFMLDIGTLDDISNIKL--H----ALNGTTLAQ 387
            |||||.|.|||||..:|        |:..:|||..:::|.:...::::|  |    :....::..
  Rat   335 DYIGSSRMVYDMENGKF--------PVRLENIDSFVELGQVALRTSLELWMHTDPMSQKNESVKN 391

  Fly   388 QILERL----NNYAKSPRYGFNLNIQSEMSAHLPPTSAQSFLRRDPNFNALIL---NARPTNKYY 445
            |:.:.|    .:.|.:|:...:..:||:.   |||:|.|.|||. .|.:.::|   :....|:||
  Rat   392 QVEDLLVTLEQSGADTPQVVLSRLVQSQA---LPPSSLQRFLRA-RNISGVVLADHSGSFHNRYY 452

  Fly   446 HSIYDDADNVDFTYANTSKDFTQLTEVNDFKSLNPDSLQMKVRNVSSIVAMALYQTITGKEYTGT 510
            .||||.|:|::.||..:......|..|.|......|        |::::|.|||:...|..:..:
  Rat   453 QSIYDTAENINVTYPESQSPEEDLNFVTDTAKALAD--------VATVLARALYKLAGGTNFNNS 509

  Fly   511 KVANPLMADEFLYCFLQSADCPLFKA------ASYPGSQLTNLPPMRYISVLGGSQESSGYTYRL 569
            ..|:|......||.||..|:...|::      .||    |.:.|...||:|    ...:..|| :
  Rat   510 IQADPQTVTRLLYGFLVRANNSWFQSILRHDLRSY----LDDGPLQHYIAV----SSPTNTTY-V 565

  Fly   570 LGYLLSQLQ---PDIHRDNCTD---LP-----LHYFAGF---------NNIGECRLTTQNYSHAL 614
            :.|.|:.|.   .::.::.|.|   :|     |:.::..         ..:..|..:|...:.||
  Rat   566 VQYALANLTGKVTNLTQEQCQDPSKVPNESKDLYEYSWVQGPWNSNKTERLPRCVRSTVRLARAL 630

  Fly   615 SPAFLIDGYDWSSGMYSTWTESTWSQFSARIFLRPSNVHQVTTLSVGIVVLIISFCLVYIISSRS 679
            ||||.:.  .|||..||||.||.|....|||||..|...:..||.||..:|:.|..:.|.|::::
  Rat   631 SPAFELS--QWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSILVFSLIVTYCINAKA 693

  Fly   680 EVLF 683
            :|||
  Rat   694 DVLF 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nct	NP_001262932.1	M28_Nicastrin	42..639	CDD:349877	190/639 (30%)
Ncstn	NP_777353.1	M28_Nicastrin	51..653	CDD:349877	190/639 (30%)