DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nct and NCSTN

DIOPT Version :9

Sequence 1:	NP_001262932.1	Gene:	Nct / 42964	FlyBaseID:	FBgn0039234	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_056146.1	Gene:	NCSTN / 23385	HGNCID:	17091	Length:	709	Species:	Homo sapiens

Alignment Length:	721	Identity:	222/721 - (30%)
Similarity:	351/721 - (48%)	Gaps:	89/721 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLILSYGATIA---QGERTRDKMYEPIG-GASCFRRLNGTHQTGCSSTYSGSVGVLHLINVEADL 72
            |.:||:...:|   :|.....|:|.|:. .|.|.|.||.|||.||.|:.||..||:|::..|.||
Human    18 LRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDL 82

  Fly    73 EFLLSSPPSPPYAPMIPPHLFTRNNLMRLKEAGPKNISVVLLINRTNQMKQFSHELNCPNQYSGL 137
            :::|:..|:|||..::....|||:.:.:||....:...:.:.:.:.:....||..:.|||...|:
Human    83 QWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGV 147

  Fly   138 NSTSETCDASNPAK-NWNPWGTGLLHEDFPFPIYYIADLDQVTKLEKCFQDFNNHNYETHALRSL 201
            .|.|...:.::..: .||..|.||.:|||.|||:.:.|.::...:::|:||.|.....:.....|
Human   148 YSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPL 212

  Fly   202 CAVEVKSFMSAAVNTEVCMRRTNFIN--NLGGSKYCDPLEGRNVYATLYPRKPAIENNLETVHTN 264
            ||:::.|.|.|.::|..||||::..:  ::.....||||...||::.|.|     .|...|:..:
Human   213 CAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKP-----INTTGTLKPD 272

  Fly   265 EKFILVTCRLDTTTMFDGVGLGAMDSLMGFAVFTHVAYLLKQLLPPQSKDLHNVLFVTFNGESYD 329
            ::.::...|||:.:.|..|..||..::..|......|..| |..|..:....||:||.|.||::|
Human   273 DRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEAL-QKAPDVTTLPRNVMFVFFQGETFD 336

  Fly   330 YIGSQRFVYDMEKLQFPTESTGTPPIAFDNIDFMLDIGTLDDISNIKL--H----ALNGTTLAQQ 388
            ||||.|.||||||.:|        |:..:|:|..:::|.:...::::|  |    :....::..|
Human   337 YIGSSRMVYDMEKGKF--------PVQLENVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQ 393

  Fly   389 ILERLNNYAKSPRYGFNLNI--QSEMSAHLPPTSAQSFLRRDPNFNALIL---NARPTNKYYHSI 448
            :.:.|....||.. |....|  :...|..|||:|.|.|||. .|.:.::|   :....||||.||
Human   394 VEDLLATLEKSGA-GVPAVILRRPNQSQPLPPSSLQRFLRA-RNISGVVLADHSGAFHNKYYQSI 456

  Fly   449 YDDADNVDFTYANTSKDFTQLTEVNDFKSLNPDSLQMKVRNVSSIVAMALYQTITGKEYTGTKVA 513
            ||.|:|::.:|.........|..|.|......|        |::::..|||:...|..::.|..|
Human   457 YDTAENINVSYPEWLSPEEDLNFVTDTAKALAD--------VATVLGRALYELAGGTNFSDTVQA 513

  Fly   514 NPLMADEFLYCFLQSADCPLFKA------ASYPGSQLTNLPPMRYISVLGGSQESSGYTYRLLGY 572
            :|......||.||..|:...|::      .||.|..    |...||:|    ...:..|| ::.|
Human   514 DPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDG----PLQHYIAV----SSPTNTTY-VVQY 569

  Fly   573 LLSQLQ---PDIHRDNCTDL------------------PLHYFAGFNN----IGECRLTTQNYSH 612
            .|:.|.   .::.|:.|.|.                  |||     :|    :..|..:|...:.
Human   570 ALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLH-----SNETDRLPRCVRSTARLAR 629

  Fly   613 ALSPAFLIDGYDWSSGMYSTWTESTWSQFSARIFLRPSNVHQVTTLSVGIVVLIISFCLVYIISS 677
            ||||||.:.  .|||..|||||||.|....|||||..|...::.||:||..:||.|..:.|.|::
Human   630 ALSPAFELS--QWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVTYCINA 692

  Fly   678 RSEVLF 683
            :::|||
Human   693 KADVLF 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nct	NP_001262932.1	M28_Nicastrin	164..471	CDD:193502	98/319 (31%)
NCSTN	NP_056146.1	M28_Nicastrin	52..654	CDD:349877	193/641 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152704
Domainoid	1	1.000	115	1.000	Domainoid score	I6054
eggNOG	1	0.900	-	-		E1_KOG2657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41029
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2784
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54418
OrthoDB	1	1.010	-	-		D280914at33208
OrthoFinder	1	1.000	-	-		FOG0005662
OrthoInspector	1	1.000	-	-		oto89949
orthoMCL	1	0.900	-	-		OOG6_104690
Panther	1	1.100	-	-	LDO	PTHR21092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2986
SonicParanoid	1	1.000	-	-		X4637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800