DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nct and aph-2

DIOPT Version :9

Sequence 1:NP_001262932.1 Gene:Nct / 42964 FlyBaseID:FBgn0039234 Length:699 Species:Drosophila melanogaster
Sequence 2:NP_492712.2 Gene:aph-2 / 172905 WormBaseID:WBGene00000148 Length:723 Species:Caenorhabditis elegans


Alignment Length:778 Identity:177/778 - (22%)
Similarity:311/778 - (39%) Gaps:153/778 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 WLLILSYGATIAQGERT---RDKMYEP--IG-GASCFRRLNGTHQTGCSSTYSGSVGVLHLINVE 69
            ||:|:    .|..|.|.   .|:::..  || |.:|:|..|.||:.||.:......|::..|:.:
 Worm     4 WLVIV----LIIAGIRCDGFSDQVFRTLFIGEGNACYRTFNKTHEFGCQANRENENGLIVRIDKQ 64

  Fly    70 ADLEFLLSSPPS--PPYA----PMIPPHLFTRNNLMRLKEAGPKNISVVLLINR------TNQMK 122
            .|.:.|.|...|  |.|:    .::|.:|..|:.:.:||.:  |.:|.::|.|.      .::..
 Worm    65 EDFKNLDSCWNSFYPKYSGKYWALLPVNLIRRDTISQLKSS--KCLSGIVLYNSGESIHPGDEST 127

  Fly   123 QFSHELNCPN---QYSGLNSTSETCDASNPAKNWNPWGT----GLLHEDFPFPIYYIADLDQVTK 180
            ..||:..|||   .|...:...|.|:     :..|..|.    ||:..|:...:.:|.:...:..
 Worm   128 AASHDAECPNAASDYYLQDKNEEYCE-----RKINSRGAITRDGLMKIDWRIQMVFIDNSTDLEI 187

  Fly   181 LEKCFQDFNNHNYETHALRSLCAVEVKSFMSAAVNTEVCMRRTN-----FINNLGGS---KYCDP 237
            :|||:..||....:..:....|.:..:....||.|:|:|.||..     |..|:...   :.|..
 Worm   188 IEKCYSMFNKPKEDGSSGYPYCGMSFRLANMAAGNSEICYRRGKNDAKLFQMNIDSGDAPQLCGA 252

  Fly   238 LEGRNVYA--TLYPRKPAIENNLETVHTNEKFILVTCRLDTTTMFDGVGLGAMDSLMG----FAV 296
            :...|::|  |..|..|    ..||:.|: |:::||.|:|:..|...:.:|.:..|..    .|.
 Worm   253 MHSDNIFAFPTPIPTSP----TNETIITS-KYMMVTARMDSFGMIPEISVGEVSVLTSIISVLAA 312

  Fly   297 FTHVAYLLKQLLPPQSKDLHNVLFVTFNGESYDYIGSQRFVYDMEKLQFP----TESTGTPPIAF 357
            ...:...:::.....:....||.|..|||||.|||||....|.||..:||    ::.|...||..
 Worm   313 ARSMGTQIEKWQKASNTSNRNVFFAFFNGESLDYIGSGAAAYQMENGKFPQMIRSDRTHIHPIRP 377

  Fly   358 DNIDFMLDIGTLDDISNIKLHA-LNG------TTLAQQILERLNNYAKSPRYGFNLNIQSEMSAH 415
            :.:|::|::..:......|.:. ::|      .|...::::|:....:|  :.|:|...|.....
 Worm   378 NELDYILEVQQIGVAKGRKYYVHVDGERYQQNKTQTDRVIDRIERGLRS--HAFDLEKPSGSGDR 440

  Fly   416 LPPTSAQSFLRRDPNFNALILNARPTNKYYHSIYDDADNVDFTYANTSKDFTQLTEVNDFKSLNP 480
            :||.|..||.:.|.:..:::|  .|..|.|          ::...|:..|..:.||....|::. 
 Worm   441 VPPASWHSFAKADAHVQSVLL--APYGKEY----------EYQRVNSILDKNEWTEDEREKAIQ- 492

  Fly   481 DSLQMKVRNVSSIVAMALYQTITGKEYTG-------TKVANPLMADEFLY-C-FLQSAD----CP 532
               :::..:.:.:.|.|.|..:...|...       |.:.:.|:...|.: | |:|..|    ..
 Worm   493 ---EIEAVSTAILAAAADYVGVETDEVVAKVDKKLITTIFDCLITSNFWFDCDFMQKLDGGRYHK 554

  Fly   533 LFKA---------------ASYP-----------GS--QLTNLPPMRYISVLGGSQESSGYTYRL 569
            ||.:               .::|           ||  :..|:...:..|.||..|....|||  
 Worm   555 LFNSYGFNQKSTYISMESHTAFPTVLHWLTIFALGSDKETLNVKSEKSCSHLGQFQAFQMYTY-- 617

  Fly   570 LGYLLSQLQPDIHRDNCTDLPLHYFAGFNNIGECRLTTQNYSHALSPAFLIDGYDWSSGM---YS 631
                             |..|..|...|:    |..:.......:|||  :|.......|   ||
 Worm   618 -----------------TWQPNPYTGNFS----CLKSAIVKKVMVSPA--VDSQTPEEEMNTRYS 659

  Fly   632 TWTESTWSQFSARIFLRPSNVHQVTTLSVGIVVLIISFCLVYIISSRSEVLFEDLPASNAASP 694
            ||.||.:...|..::|......:.|.:.:.::..::|...|...|..:.::.|..||:....|
 Worm   660 TWMESVYIIESVNLYLMEDASFEYTMILIAVISALLSIFAVGRCSETTFIVDEGEPAAEGGEP 722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NctNP_001262932.1 M28_Nicastrin 164..471 CDD:193502 78/331 (24%)
aph-2NP_492712.2 M28_Nicastrin 171..500 CDD:193502 81/351 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160162579
Domainoid 1 1.000 66 1.000 Domainoid score I6603
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H41029
Inparanoid 1 1.050 119 1.000 Inparanoid score I3355
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54418
OrthoDB 1 1.010 - - D280914at33208
OrthoFinder 1 1.000 - - FOG0005662
OrthoInspector 1 1.000 - - oto20639
orthoMCL 1 0.900 - - OOG6_104690
Panther 1 1.100 - - LDO PTHR21092
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2986
SonicParanoid 1 1.000 - - X4637
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.940

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