DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and YGR125W

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_011641.1	Gene:	YGR125W / 853026	SGDID:	S000003357	Length:	1036	Species:	Saccharomyces cerevisiae

Alignment Length:	714	Identity:	130/714 - (18%)
Similarity:	258/714 - (36%)	Gaps:	204/714 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EDG-----KKVKPTVSTLDCTRSWLQDCQRRTFNRKTLHKRLP--ILGWLPKYNSQDAVGDLVAG 106
            |||     :.::|:.:.....|:....|  .:|..|..| .||  :||.|  .|..||
Yeast   172 EDGYAGGYQSLRPSHNLRFRPRNLWHMC--TSFPSKFAH-YLPAAVLGLL--LNILDA------- 224

  Fly   107 ITVGLTVIP---QALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKDVPMGPSA----------I 158
            ::.|:.:.|   ...::.|..|:.:.|  .::.:...||  .|.....|.|..:          .
Yeast   225 LSYGMIIFPITEPVFSHLGPTGISMFY--ISTIISQAVY--SGGWSSFPSGIGSEMIEITPFYHT 285

  Fly   159 VALLTYQAAQGSWQK---SVLLC-----LLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLI 215
            :||...:|..|:..:   :.:.|     :|:|:|...:|...||.::.|....:..|....|...
Yeast   286 MALAIKEALAGNDDEIITTTIFCYVISSMLTGVVFYALGKLRLGKIVGFFPRHILIGCIGGVGYF 350

  Fly   216 ILTSQIQSVLGITAKGNTFVEIW---TQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGPV 277
            ::.:.|:    :|.:...|...|   :.:|.:.      ||:......|:|.::
Yeast   351 LIITGIE----VTTRVAKFEYSWPFFSGLFTDY------DTLAKWLLPVLLTVV----------- 394

  Fly   278 DEKECSSFQRAVNKILWIVGTAR---NAILVVVCCIMGYMLHTEEHGAPFRVVGEIPPGLPSIQL 339
                             ::||.|   |::::....|:..:|        |..:..|   :|::.|
Yeast   395 -----------------LIGTQRYFKNSLVLPSFYILTLVL--------FHFIVAI---IPTLSL 431

  Fly   340 PPTSLT------ANETSNGVAEGFVEMVHSMGSGLVVIPLISLME-----------NIAICKAFA 387
            ......      ||..|.......:..||.:...||:..:.::|.           |:.......
Yeast   432 DALRQAGWIFPIANSDSKWYDHYRLFNVHKVHWSLVLQQIPTMMALTFFGILHVPINVPALAMSL 496

  Fly   388 NGKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAV--NNASGVRTPLSNIYSGGLVM---IA 447
            .....|..:||||.|.:|.|:..:      |::....|  |:...:|....:.::|.|::   |.
Yeast   497 QMDKYDVDRELIAHGYSNFFSGLL------GSVQNYLVYTNSVLFIRAGADSPFAGFLLIALTIC 555

  Fly   448 LLFLTPYFY-FIPRPTLAAIIISAVVFMIE----VKVVKPMWRSKKS----------------DL 491
            ::.:.|... |||     ..|:.:::|::.    |:.:...|.....                |.
Yeast   556 IMIIGPVIISFIP-----ICIVGSLIFLLGYELLVEALVDTWNKLNRFEYLTVVIIVFTMGIFDF 615

  Fly   492 VPG--VGTFVACLVLPLEWGILIGVGLNVIFILY--HAARPKLSTELLTTQ----SGVEYSMITP 548
            |.|  ||..:||...     ::....|..|...|  :.||..:..:.:.|:    .|.:..::..
Yeast   616 VLGIIVGILIACFSF-----LVDSTKLQTINGEYNGNVARSTVYRDYVQTKFLDGIGEQIYVLKL 675

  Fly   549 DRCLIF-------PSVDYVRNLVNKQSIRQNVP-VVIDASHV------YGA--------DFTTAT 591
            ...|.|       ..::.:..:.||.:.::.:. :::|..::      |.|        .||...
Yeast   676 QNLLFFGTIISIEEKIERLLQISNKDATKRRIKYLILDFKNINADNIDYSAAEGFNRIKRFTETK 740

  Fly   592 VIDSLISDFNQRGQLLFFYNLKPSI-----CSIFEHVSAA------QFVVYYQEQQLDELLKER 644
            .|..:||...:|.::   ||...::     ..:|..:::|      :|:  :|.:||.:..|||
Yeast   741 RIKLIISSIKERDRI---YNAFNNVGLLNDVELFADLNSALEWCENEFL--FQYKQLRKKAKER 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	111/630 (18%)
		HCO3_cotransp	103..520	CDD:304903	83/488 (17%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	16/104 (15%)
YGR125W	NP_011641.1	SUL1	128..785	CDD:223732	123/696 (18%)
YGR125W	NP_011641.1	CAP_ED	910..1014	CDD:237999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810