DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and SUL1

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_009853.3	Gene:	SUL1 / 852597	SGDID:	S000000498	Length:	859	Species:	Saccharomyces cerevisiae

Alignment Length:	601	Identity:	169/601 - (28%)
Similarity:	269/601 - (44%)	Gaps:	112/601 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PILGWLPKYNSQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKD 150
            ||:.|.|.||......|||||||||..::||:::||.||.|...||||:||:|.|:|....:.||
Yeast   108 PIIKWFPHYNFTWGYADLVAGITVGCVLVPQSMSYAQIASLSPEYGLYSSFIGAFIYSLFATSKD 172

  Fly   151 VPMGPSAIVALLTYQAAQGSWQK-------------SVLLCLLSGIVELLMGLFGLGFLIDFVSG 202
            |.:||.|:::|.|.:......:|             :..||||.|||...:|:..||||::.:|.
Yeast   173 VCIGPVAVMSLQTAKVIAEVLKKYPEDQTEVTAPIIATTLCLLCGIVATGLGILRLGFLVELISL 237

  Fly   203 PVSSGFTSAVSLIILTSQIQSVLGITAKGNTFVEIWTQVFHNIEH---TRAGDTVLGLTCIVILL 264
            ...:||.:..:..|:..||.:::|..:..||....:..|.:.::|   |:. |.|.||..:|||.
Yeast   238 NAVAGFMTGSAFNIIWGQIPALMGYNSLVNTREATYKVVINTLKHLPNTKL-DAVFGLIPLVILY 301

  Fly   265 LMRSLSSCRIGPVDEKECSSF------------QRAVNKI---LWIVGTARNAILVVVCCIMGYM 314
            :.:..            |.:|            .:..|::   .:.....|||:::||...:.:.
Yeast   302 VWKWW------------CGTFGITLADRYYRNQPKVANRLKSFYFYAQAMRNAVVIVVFTAISWS 354

  Fly   315 L--HTEEHGAPFRVVGEIPPGLPSIQLP--PTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLIS 375
            :  :......|..::|.:|.||..:.:.  |..|.:|                |.|.:....::.
Yeast   355 ITRNKSSKDRPISILGTVPSGLNEVGVMKIPDGLLSN----------------MSSEIPASIIVL 403

  Fly   376 LMENIAICKAFA--NGKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNI 438
            ::|:|||.|:|.  |...|...|||||||..|:..:|..::|.||:.||.|:.....||||.|.:
Yeast   404 VLEHIAISKSFGRINDYKVVPDQELIAIGVTNLIGTFFHSYPATGSFSRSALKAKCNVRTPFSGV 468

  Fly   439 YSGGLVMIALLFLTPYFYFIPRPTLAAIIISAVV-FMIEVKVVKPMWRSKKSDLVPGVGTFVACL 502
            ::||.|::||..||..|:|||:.||:|:||.||. .:...|.....|::...|.:..:.|....:
Yeast   469 FTGGCVLLALYCLTDAFFFIPKATLSAVIIHAVSDLLTSYKTTWTFWKTNPLDCISFIVTVFITV 533

  Fly   503 VLPLEWGILIGVGLNVIFILYHAARPKLS-------TELL--TTQSGV-----------EYSMIT 547
            ...:|.||...:..:...:|...|.|...       .|:|  |.|..:           |.:...
Yeast   534 FSSIENGIYFAMCWSCAMLLLKQAFPAGKFLGRVEVAEVLNPTVQEDIDAVISSNELPNELNKQV 598

  Fly   548 PDRCLIFPSVD-------------YVRNLVNKQSIRQNVPVVIDASHVY--GADFTTAT------ 591
            .....:.|:.:             |.|.|....::|...|.||    ||  |..||...
Yeast   599 KSTVEVLPAPEYKFSVKWVPFDHGYSRELNINTTVRPPPPGVI----VYRLGDSFTYVNCSRHYD 659

  Fly   592 VIDSLISDFNQRGQLL 607
            :|...|.:..:||||:
Yeast   660 IIFDRIKEETRRGQLI 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	169/601 (28%)
		HCO3_cotransp	103..520	CDD:304903	135/454 (30%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	19/84 (23%)
SUL1	NP_009853.3	SUL1	102..784	CDD:223732	169/601 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341584
Domainoid	1	1.000	211	1.000	Domainoid score	I497
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I705
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		mtm9191
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
TreeFam	1	0.960	-	-
	13	12.780