Protein Alignment Esp and Slc26a5

DIOPT Version :9

• Sequence 1: NP_001189282.1
• Gene: Esp / 42962
• FlyBaseID: FBgn0013953
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_109652.3
• Gene: Slc26a5 / 80979
• MGIID: 1933154
• Length: 744
• Species: Mus musculus
• Alignment Length: 603
• Identity: 154/603 - (25%)
• Similarity: 275/603 - (45%)
• Gaps: 125/603 - (20%)

  Fly    43 KEFILTEDGKKVKPTVSTLDCTRSWLQDCQRRTFNRKTLHKRLPILGWLPKYNSQDAV-GDLVAG 106
            |:.:....|.|:|   ....||...:         |..::..|||..|||.|..::.| ||||:|
Mouse    35 KDKVTESIGDKLK---QAFTCTPKKI---------RNIIYMFLPITKWLPAYKFKEYVLGDLVSG 87

  Fly   107 ITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKDVPMGPSAIVALLT-------- 163
            |:.|:..:||.||:|.:|.:|..:|||:||....:|.|.|:.:.:.:||.|:::|:.
Mouse    88 ISTGVLQLPQGLAFAMLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLV 152

  Fly   164 ---------YQAAQGSWQKSVL-------LCLLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAV 212
                     ..|..|:..:..|       :.|||||::..:|:...||:..:::.|:..|||:|.
Mouse   153 PDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAA 217

  Fly   213 SLIILTSQIQSVLGITAKGNTFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGP- 276
            ::.:.||.::.:.|:..|  .:..|::.|:               :.:.:|..:::|:.|.:|.
Mouse   218 AVHVFTSMLKYLFGVKTK--RYSGIFSVVY---------------STVAVLQNVKNLNVCSLGVG 265

  Fly   277 -------VDEKECSSFQRAVNKI---------LWIVGTARNAILVVVCCIMGYMLHTEEHGAPFR 325
                   :..||.:  :|...|:         ..::||..:|         |:.|| |.:...
Mouse   266 LMVFGLLLGGKEFN--ERFKEKLPAPIPLEFFAVVMGTGISA---------GFNLH-ESYSVD-- 316

  Fly   326 VVGEIPPGLPSIQLPPTSLTAN-ETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFAN- 388
            |||.:|.||    |||    || :||         :.|.:....:.|.::.....|::.|..||
Mouse   317 VVGTLPLGL----LPP----ANPDTS---------LFHLVYVDAIAIAIVGFSVTISMAKTLANK 364

  Fly   389 -GKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLT 452
             |..||.:|||||:|..|...|..|.|..:.:|||..|...:|.:|.|:...:.  :||.|:.|.
Mouse   365 HGYQVDGNQELIALGICNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLAS--LMILLVILA 427

  Fly   453 PYFYF--IPRPTLAAIIISAV--VFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIG 513
            ..|.|  :|:..|:||:|..:  :|| :...:...||:.|.:|...:.|||:.|.|.|::|::..
Mouse   428 TGFLFESLPQAVLSAIVIVNLKGMFM-QFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITA 491

  Fly   514 VGLNVIFILYHAARP--KLSTELLTTQSGVEYSMITPDRCLIFPSVDYVRNLVNKQSIRQNVPVV 576
            |.:.::.::|....|  |:..:|..|           |..:...:.:.|:.:...:..:.|.|:.
Mouse   492 VIIALLTVIYRTQSPSYKVLGQLPDT-----------DVYIDIDAYEEVKEIPGIKIFQINAPIY 545

  Fly   577 IDASHVYGADFTTATVID 594
            ...|.:|.:.....|.::
Mouse   546 YANSDLYSSALKRKTGVN 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	146/560 (26%)
		HCO3_cotransp	103..520	CDD:304903	125/464 (27%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	7/50 (14%)
Slc26a5	NP_109652.3	sulP	66..709	CDD:273284	146/560 (26%)
		STAS_SulP_like_sulfate_transporter	526..694	CDD:132913	6/38 (16%)
		STAS_anti-anti-sigma_factors	589..683	CDD:132914
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	720..744

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740