Protein Alignment Esp and SLC26A6

DIOPT Version :9

• Sequence 1: NP_001189282.1
• Gene: Esp / 42962
• FlyBaseID: FBgn0013953
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_075062.2
• Gene: SLC26A6 / 65010
• HGNCID: 14472
• Length: 759
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 147/581 - (25%)
• Similarity: 280/581 - (48%)
• Gaps: 95/581 - (16%)

  Fly    65 RSWLQDCQRRTFNRKTLHKRLPILGWLPKYNSQD-AVGDLVAGITVGLTVIPQALAYAGIAGLPV 128
            |:|||..:.|.:  ..|.:.||:|.|||:|..:| .:|||::|::|.:..:||.||||.:||||.
Human    57 RTWLQCSRARAY--ALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPP 119

  Fly   129 AYGLYASFVGCFVYIFLGSCKDVPMGPSAIVAL--------LTYQAAQGSW-----------QKS 174
            .:|||:||...|:|...|:.:.:.:|..|::::        |..||...|.           |.:
Human   120 VFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVA 184

  Fly   175 VLLCLLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLG--ITAKGNTFVEI 237
            ..|.:|.|:.::.:||...||::.::|.|:..|:|:|.::.:..||::.|.|  :::.......|
Human   185 STLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLI 249

  Fly   238 WT--QVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTAR 300
            :|  :|...:..::.|..|......|:|::::.|:       |:.:.........::|.::|...
Human   250 YTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLN-------DKLQQQLPMPIPGELLTLIGATG 307

  Fly   301 NAILVVVCCIMGYMLHTEEHGAPFRVVGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMG 365
                  :...||.     :|.....|||.||.||    :||.:......|..|...|
Human   308 ------ISYGMGL-----KHRFEVDVVGNIPAGL----VPPVAPNTQLFSKLVGSAF-------- 349

  Fly   366 SGLVVIPLISLMENIAICKAFA--NGKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNA 428
                .|.::.....|::.|.||  :|..||::|||:|:|.:|:.....|.||.:.::||..|..:
Human   350 ----TIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQES 410

  Fly   429 SGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRPTLAAIIISAVVFMI-EVKVVKPMWRSKKSDLV 492
            :|..:.::...|...:::.::.|...|:.:|:..||||||..:..|: ::..::.:|::.::||:
Human   411 TGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLL 475

  Fly   493 PGVGTFVACLVLPLEWGILIGVGLNVIFILYHAARPKLSTELLTTQSGVEYSMITPDRCLIFPSV 557
            ..:.||.|.::|.|:.|:::.|..:::.::.....|             .||::..     .|..
Human   476 IWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMP-------------HYSVLGQ-----VPDT 522

  Fly   558 DYVRNLVNKQSIRQ--NVPVVIDASHVY--GADFTTATV-------IDSLISDFNQRGQLL 607
            |..|::......::  .|.|...::.||  .|:|.:..:       :|.|||   |:.:||
Human   523 DIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLIS---QKKKLL 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	140/560 (25%)
		HCO3_cotransp	103..520	CDD:304903	112/442 (25%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	16/74 (22%)
SLC26A6	NP_075062.2	sulP	76..738	CDD:273284	140/560 (25%)
		HCO3_cotransp	<299..451	CDD:304903	47/178 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..657
		STAS_SulP_like_sulfate_transporter	<656..735	CDD:132913

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740