DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and Slc26a1

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_071623.2	Gene:	Slc26a1 / 64076	RGDID:	620136	Length:	703	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	136/542 - (25%)
Similarity:	242/542 - (44%)	Gaps:	103/542 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SQGSKEFILTEDGKKVKPTVSTLDCTRSWLQDCQRRTFNRKTLHKRLPILGWLPKYNSQD-AVGD 102
            |||..|   |...:..|....::.|.::.:|..             .|::.|||:|..:: ..||
  Rat    24 SQGLLE---TLKARLKKSCTCSMPCAQALVQGL-------------FPVIRWLPQYRLKEYLAGD 72

  Fly   103 LVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKDVPMGPSAIVALLTYQAA 167
            :::|:.:|:.::|||:||:.:|||...|.||.||....:|..:|:.:.|.:|..:::.|:..|..
  Rat    73 VMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVNVGIFSLLCLMVGQVV 137

  Fly   168 QGSWQK-----------------------------------------SVLLCLLSGIVELLMGLF 191
            ....|.                                         :..|.|::|:.::|||:.
  Rat   138 DRELQLAGFDPSQDSLGPGNNDSTLNNTATLTVGLQDCGRDCHAIRIATALTLMAGLYQVLMGIL 202

  Fly   192 GLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGITAKGN----TFVEIWTQVFHNIEHTRAGD 252
            .|||:..::|.|:..||....|:.|||||.:.:||:....:    ..:..|..:..|:......|
  Rat   203 RLGFVSTYLSQPLLDGFAMGASVTILTSQAKHLLGVRIPRHQGLGMVIHTWLSLLQNVGQANLCD 267

  Fly   253 TVLGLTCIVILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIMGY--ML 315
            .|....|:.:||             ..||.|...|...|    |......:::||..|..:  .|
  Rat   268 VVTSAVCLAVLL-------------TAKELSDRYRHYLK----VPVPTELLVIVVATIASHFGQL 315

  Fly   316 HTEEHGAPFRVVGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENI 380
            ||....:   |.|.||.|..:.|:|..                :::.|:....:.:.|:....:|
  Rat   316 HTRFGSS---VAGNIPTGFVAPQIPDP----------------KIMWSVALDAMSLALVGSAFSI 361

  Fly   381 AICKAFA--NGKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGL 443
            ::.:.||  :|..|.|:|||:|:|..|:..:|...|..:.|||:..|..|:|.:|.||::.|..:
  Rat   362 SLAEMFARSHGYSVSANQELLAVGCCNVLPAFFHCFATSAALSKTLVKIATGCQTQLSSVVSAAV 426

  Fly   444 VMIALLFLTPYFYFIPRPTLAAIIISAVVFMI-EVKVVKPMWRSKKSDLVPGVGTFVACLVLPLE 507
            |::.||.|.|.|:.:.|..||.||:.::...: :||.:..:||...:|.:..|.|...|:::.:|
  Rat   427 VLLVLLVLAPLFHDLQRCVLACIIVVSLRGALRKVKDLPQLWRLSPADALVWVATAATCVLVSIE 491

  Fly   508 WGILIGVGLNVIFILYHAARPK 529
            .|:|.||..:::.:.....||:
  Rat   492 AGLLAGVFFSLLSLAGRTQRPR 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	128/495 (26%)
		HCO3_cotransp	103..520	CDD:304903	119/466 (26%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913
Slc26a1	NP_071623.2	sulP	55..685	CDD:273284	128/495 (26%)
Slc26a1	NP_071623.2	STAS_SulP_like_sulfate_transporter	537..682	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810