DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and CG7912

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_651761.2	Gene:	CG7912 / 43561	FlyBaseID:	FBgn0039736	Length:	602	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	219/537 - (40%)
Similarity:	330/537 - (61%)	Gaps:	30/537 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 RRTFNRKTLHKRLPILGWLPKYNSQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFV 137
            |...:.:::|:.||:..|||||.......|:|||:|||||.:|||:||..:|.||.|||||::|:
  Fly    25 RSCCSMRSVHRYLPVTDWLPKYQLNFLAMDVVAGLTVGLTAVPQAIAYGAVANLPPAYGLYSAFM 89

  Fly   138 GCFVYIFLGSCKDVPMGPSAIVALLTYQAAQGSWQKSVLLCLLSGIVELLMGLFGLGFLIDFVSG 202
            |.||||.||:|||:.:||:||:||:......|:...:||:|.|||.:..||||..||.|:.|:|.
  Fly    90 GGFVYILLGTCKDITVGPTAIMALMVQPYVDGNPAYAVLICFLSGCIITLMGLLNLGVLMRFISV 154

  Fly   203 PVSSGFTSAVSLIILTSQIQSVLGITAKGNTFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLMR 267
            ||::|||.|.:|.|.|.|:.|:.||::..:.|:..|...|.:|..||..|.:||...:|:|||||
  Fly   155 PVTTGFTMAAALTIATGQVNSLFGISSSASGFLNSWIYFFGHITQTRRNDAILGCCTLVLLLLMR 219

  Fly   268 SLSSCRIGPVDEKECSSFQRAVNKILW-IVGTARNAILVVVCCIMGYMLHTEEHGAPFRVVGEIP 331
            .|.:...|              .|.:| .:..||||:.|::..::.|:|..:.. .||.|.|.|.
  Fly   220 QLKNLTFG--------------FKSVWKYISLARNAVAVLIGILLCYLLKNDGK-LPFLVSGSIT 269

  Fly   332 PGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFANGKPVDASQ 396
            ||||..:|||......||...::  |..||.::|:.||.|||:|::|:||:.|||:.||.|||||
  Fly   270 PGLPPFKLPPFHTEDPETGETIS--FGGMVSNVGTALVSIPLLSILESIAVAKAFSKGKIVDASQ 332

  Fly   397 ELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRP 461
            |:||:|.:||.:||..:.|.||:.:|.|:||||||:|||....:|.||::.|.|||..|.:||:.
  Fly   333 EMIALGVSNILSSFFSSMPITGSFTRTAINNASGVKTPLGGAVTGALVLMTLAFLTTTFAYIPKA 397

  Fly   462 TLAAIIISAVVFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAA 526
            |||||||:|:.||:|.:.:..:||:||.|::|.:.|.:.|:...||:|:::|:..|.:|:||.:.
  Fly   398 TLAAIIIAAMFFMVEYETIGEIWRAKKRDMLPFLVTVLTCVFWTLEYGMVVGIVFNALFLLYKSM 462

  Fly   527 RPKLSTELLTTQ--SGVEYSMITPDRCLIFPSVDYVR-NLV------NKQSIRQNVPVVIDASHV 582
            :|:.   .|||:  :|:|.:|......:.:.:.:|:: :||      |.:.......|||....:
  Fly   463 KPQF---FLTTEKFNGIEVTMADLKGSVDYAAAEYLKMSLVSHVTQRNSEGSAPTTLVVIKGHEI 524

  Fly   583 YGADFTTATVIDSLISD 599
            ...|.|.|..:.||..|
  Fly   525 ASIDTTVALNLKSLRED 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	216/524 (41%)
		HCO3_cotransp	103..520	CDD:304903	186/417 (45%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	14/62 (23%)
CG7912	NP_651761.2	sulP	38..542	CDD:273284	216/524 (41%)
CG7912	NP_651761.2	STAS	485..582	CDD:294402	13/57 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439033
Domainoid	1	1.000	214	1.000	Domainoid score	I761
eggNOG	1	0.900	-	-		E1_COG0659
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I1009
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm25858
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	P	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
	12	11.830