DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and CG5404

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_650482.1	Gene:	CG5404 / 41901	FlyBaseID:	FBgn0038354	Length:	627	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	177/580 - (30%)
Similarity:	324/580 - (55%)	Gaps:	31/580 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 RKTLHKRLPILGWLPKYNSQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVY 142
            ::.||:.:|:..|||.|:::..:.|.:||||:|||:||:::|.|.:||||..|||.::|:|..:|
  Fly    42 KRRLHRHVPVFQWLPLYSTEWGIDDFIAGITLGLTIIPESMACALLAGLPARYGLCSAFIGPLIY 106

  Fly   143 IFLGSCKDVPMGPSAIVALLTYQAAQG-SWQKSVLLCLLSGIVELLMGLFGLGFLIDFVSGPVSS 206
            :..||...|.:||:::|||::.|...| ..:.:.||..|||||:::||...:||:.:|:|.||..
  Fly   107 MVFGSIDKVIIGPTSLVALVSVQFTVGRPIEFAFLLTFLSGIVQIIMGTMRMGFIFEFISMPVIK 171

  Fly   207 GFTSAVSLIILTSQIQSVLGITAKGNTFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSS 271
            .|:||.:::::.||::.:|||.......:.....:...||.:...|.::|:..||.|||:..|.
  Fly   172 AFSSATAILVIESQLKVLLGIKYLVAGLMNSVGMLSSRIEESNMADLIMGVCAIVFLLLLELLD- 235

  Fly   272 CRIGPVDEKECSSFQRAVNKILWI----VGTARNAILVVVCCIMGYMLHTEEHGAPFRVVGEIPP 332
             |:...:::         ||||.|    :.|:||.::|::..|:.::...:....|:.:......
  Fly   236 -RVANNEKR---------NKILRIFCRYLSTSRNTLIVLIAAIVSFIWIQKCGQVPYALSKNALS 290

  Fly   333 GLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFANGKPVDASQE 397
            .||:..:|...:...|.:..:    .|::..:..|::|||::.::.||:|.|....|. ||.:||
  Fly   291 TLPNFTVPSFHIETAERNYSI----WEVLKELNIGIIVIPIVGILTNISIGKLTPKGL-VDTNQE 350

  Fly   398 LIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRPT 462
            |:.:|..|:|.|.|||.|.:||.:|.|::.|.|:|||::|:|.|.:|::||.:|:|||.:||..|
  Fly   351 LLTVGLCNMFGSCVQAMPSSGAFTRYAISTACGLRTPMANLYLGIIVLLALSYLSPYFNYIPEAT 415

  Fly   463 LAAIIISAVVFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAAR 527
            ||||:|.::..:::.|:...:||..|.|....:..|...::..:|.|:.:.:.:..:.:|:..||
  Fly   416 LAAILICSIFTLLDFKLPMRLWRDSKRDFATWLLCFCVSVLFGVEVGLFVSIVVTALHLLFLWAR 480

  Fly   528 PKLSTELLTTQSGVEYSMITPDRCLIFPSVDYVRNLVNK--QSIRQNVPVVIDASHVYGADFTTA 590
            |::..::..... ::|..:||...:.||:::|:|..|.|  :.....:.||||...:.|.|:|.|
  Fly   481 PEIRVKIEQLDE-MQYIRVTPSNGIYFPAINYLRERVLKACEQADFRITVVIDGQRISGMDYTAA 544

  Fly   591 TVIDSLISDFNQRGQ-----LLFFYNLKPSICSIFEHVSAAQFVVYYQEQQLDELLKERN 645
            ..|..|.||..::..     ||..:.....:..:.::..  ..|....|.::.|.|.:.:
  Fly   545 QGISKLSSDLCRQADASSSTLLILFRFPEHLQRLIDNTD--NLVFCESENKVKEFLTQES 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	171/540 (32%)
		HCO3_cotransp	103..520	CDD:304903	138/421 (33%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	22/84 (26%)
CG5404	NP_650482.1	sulP	50..557	CDD:273284	169/523 (32%)
CG5404	NP_650482.1	STAS_SulP_like_sulfate_transporter	498..>554	CDD:132913	19/55 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439016
Domainoid	1	1.000	214	1.000	Domainoid score	I761
eggNOG	1	0.900	-	-		E1_COG0659
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I1009
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm51364
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
	10	9.900