Protein Alignment Esp and Prestin

DIOPT Version :10

• Sequence 1: NP_524490.2
• Gene: Esp / 42962
• FlyBaseID: FBgn0013953
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Alignment Length: 639
• Identity: 151/639 - (23%)
• Similarity: 271/639 - (42%)
• Gaps: 152/639 - (23%)

  Fly    28 TEPNGSSNSVGSQGS-------------------KEFILTEDG--KKVKPTVSTL-DCTRSWLQD 70
            |:|..::|:.|:.||                   .|.::.:.|  .:.|...|:| :|.|||
  Fly    10 TKPLNNNNTNGNGGSVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCWRSW--- 71

  Fly    71 CQRRTFNRKTLHKR-LPILGWLPKYN-SQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLY 133
                  |...|... :|||.|||:|: .:|..||::||.||.:..||..:||..:||:....|||
  Fly    72 ------NFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLY 130

  Fly   134 ASFVGCFVYIFLGSCKDVPMGPSAIVALLTYQA----------------------AQGSWQKSVL 176
            .:......|:|||:.|.:.:|..|:.:::|.:.                      :.|:...|.|
  Fly   131 MAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPL 195

  Fly   177 LCLLS----------------------------------------GIVELLMGLFGLGFLIDFVS 201
            |.:.|                                        |||.|||....||.|...:|
  Fly   196 LLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLS 260

  Fly   202 GPVSSGFTSAVSLIILTSQIQSVLGITA---KGNTFVEIWT--QVFHNIEHTRAGDTVLGLTCIV 261
            .|:.:|||:|.:..::|:|::.||||:.   || .|..|:|  .|...:..|...:....:..|.
  Fly   261 EPLVNGFTTAAACHVVTAQLKDVLGISVPRHKG-AFKIIYTVIDVIKGVPQTNLVNFGFCMAVIA 324

  Fly   262 ILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIMGYMLHTEEHGAPFRV 326
            .:::...:...|:    .|:| .|......|:.|.||..:         ..:.|:.:.:..|
  Fly   325 FMMICNEILKPRL----SKKC-RFPLPAELIMVIGGTLIS---------KWFNLYVDYNVNP--- 372

  Fly   327 VGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFANGKP 391
            ||:||.|||...||...|......:.:|              :.|...|::.::.:..|..:|..
  Fly   373 VGKIPSGLPEPVLPRLDLVPKVAVDSIA--------------IAIVTYSIIMSMGLTFAKKHGYE 423

  Fly   392 VDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFY 456
            |..:|||.|:|..|:........|...:|||..:.:.:|..:.::::.|..||::.|:::.|:|.
  Fly   424 VRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFS 488

  Fly   457 FIPRPTLAAIIISAV--VFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVI 519
            .:||..||.:||.|:  :|| :.|.:|...:..|.::...:.||:..:::.::.|:|||:.::::
  Fly   489 SLPRCVLAGVIIVALKPMFM-QAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLL 552

  Fly   520 FILYHAARPKLSTELLTTQSGVEYSMI---TPDRCLIFPSVDYVRNLVNKQSIR 570
            .:.....:|              ||.:   .|:...|:..::..||.:....:|
  Fly   553 ALYIKGLKP--------------YSCLLGYMPEAPGIYMDLNQHRNAMQVPEVR 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_524490.2	SUL1	93..622	CDD:440424	128/551 (23%)
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	134/558 (24%)