DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and Slc26a11

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_038943458.1	Gene:	Slc26a11 / 360670	RGDID:	1306178	Length:	593	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	222/549 - (40%)
Similarity:	338/549 - (61%)	Gaps:	34/549 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 NRKTLHKRLPILGWLPKYNSQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFV 141
            :|..|.:|||:|.|||.|:.:....|::||::|||||||||||||.:||||..||||::|:||||
  Rat     9 SRADLRRRLPVLAWLPNYSLRWLRMDVIAGLSVGLTVIPQALAYAEVAGLPPQYGLYSAFMGCFV 73

  Fly   142 YIFLGSCKDVPMGPSAIVALLT--YQAAQGSWQKSVLLCLLSGIVELLMGLFGLGFLIDFVSGPV 204
            |..||:.:||.:||:||::||.  |...:.::  :|||..|||.::|.|||..||||:||:|.||
  Rat    74 YFVLGTSRDVTLGPTAIMSLLVSYYTFREPAY--AVLLAFLSGCIQLAMGLLHLGFLLDFISCPV 136

  Fly   205 SSGFTSAVSLIILTSQIQSVLGITAKGNTFVEIWTQVFHNIEH---TRAGDTVLGLTCIVILLLM 266
            ..|||||.|:.|...|::::||:.   |...:.:.||:|...|   ||.||.:|||.|:|:||::
  Rat   137 IKGFTSAASITIGFGQVKNLLGLQ---NIPRQFFLQVYHTFLHIGETRVGDAILGLVCMVLLLVL 198

  Fly   267 RSLSSCRIGPVDEKECS-SFQRAVNKILWIVGTARNAILVVVCCIMGYMLH-TEEHGAPFRVVGE 329
            :.:......|..|.... .|.|.   ::|.|.|||||::|....::.|... |..|  ||.:.|:
  Rat   199 KLMREHIPPPHPEMPLGVKFSRG---LVWTVTTARNALVVSFAALIAYAFEVTGSH--PFILTGK 258

  Fly   330 IPPGLPSIQLPPTSLTA-NETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFA--NGKP 391
            |..|||.:::||.|:|. |:|.:     |.|||..||.||.|:||:.|:|.||:.|:||  |...
  Rat   259 IAQGLPPVRMPPFSVTTDNKTIS-----FSEMVQDMGVGLAVVPLMGLLETIAVAKSFASQNNYR 318

  Fly   392 VDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFY 456
            :||:|||:|||..|:..|.|.::|.||:..|.|||..:||.||...:.:|.||:::|.:||..||
  Rat   319 IDANQELLAIGLTNVLGSLVSSYPVTGSFGRTAVNAQTGVCTPAGGLVTGVLVLLSLDYLTLLFY 383

  Fly   457 FIPRPTLAAIIISAVVFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFI 521
            :||:..|||:||.||..:.:||:.:.:|..::.||:|...||:... ..:::|||.|..::::.:
  Rat   384 YIPKSALAAVIIMAVAPLFDVKIFRRLWLVQRLDLLPLCVTFLLSF-WEIQYGILAGTLVSLLIL 447

  Fly   522 LYHAARPKLSTELLTTQSGVEYSMITPDRCLIFPSVDYVRNLVNKQSIRQNVP--VVIDASHVYG 584
            |:..||||      |..|..:..::.|...|.||:||.:|..:.|:::..:.|  .|::.:||..
  Rat   448 LHSVARPK------TQVSEGQILVLQPASGLHFPAVDALREAMTKRALEASPPRSAVLECTHVSN 506

  Fly   585 ADFTTATVIDSLISDFNQRGQLLFFYNLK 613
            .|:|....:..|:.||.::|..|.|..|:
  Rat   507 IDYTVILGLGELLEDFQKKGVTLAFVGLQ 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	218/540 (40%)
		HCO3_cotransp	103..520	CDD:304903	183/426 (43%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	21/71 (30%)
Slc26a11	XP_038943458.1	sulP	18..542	CDD:273284	218/540 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335192
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55446
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm45112
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.860