DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and slc26a11

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_956061.1	Gene:	slc26a11 / 327138	ZFINID:	ZDB-GENE-030131-5349	Length:	572	Species:	Danio rerio

Alignment Length:	572	Identity:	217/572 - (37%)
Similarity:	328/572 - (57%)	Gaps:	32/572 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 LHKRLPILGWLPKYNSQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFL 145
            |....||:.|||:||......|::||:|||||.:|||||||.:|||||.||||::|:|.|:|...
Zfish    11 LRSCFPIITWLPRYNLTWLKMDVIAGLTVGLTAVPQALAYAEVAGLPVQYGLYSAFMGGFIYCIF 75

  Fly   146 GSCKDVPMGPSAIVALLTYQAAQGSWQKSVLLCLLSGIVELLMGLFGLGFLIDFVSGPVSSGFTS 210
            |:.||:.:||:||::||......|....:|:|.||.|:::..|.|..||||:||:|.||..|||.
Zfish    76 GTSKDITLGPTAIMSLLCSSYITGDPVFAVVLTLLCGVIQTGMALLRLGFLLDFISYPVIKGFTC 140

  Fly   211 AVSLIILTSQIQSVLGI-TAKGNTFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLM----RSLS 270
            |.::.|...|::::||: ......|:::: ..||.|...|.||.:|||:|:..||::    .||:
Zfish   141 AAAVTIGFGQVKNILGLKEIPQQFFLQVY-YTFHKIPEARVGDVILGLSCLFFLLILTFMKNSLN 204

  Fly   271 SCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIMGYMLHTEEHGAP-FRVVGEIPPGL 334
            |.      |.|.|...|:..::||.:.|.|||::|:...  |.....|..|.. |.:.|:...||
Zfish   205 SA------EDEASFLVRSARQLLWSLATIRNALVVIAAA--GVAFSAEVTGNHFFSLTGKTAKGL 261

  Fly   335 PSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFA--NGKPVDASQE 397
            |..:.||.|.|   .:||....|.::...:|.||.||||:.::|:|||.|||.  |...:||:||
Zfish   262 PPFRAPPLSET---IANGTVITFSDIAKDLGGGLAVIPLMGVLESIAIAKAFGSKNNYRIDANQE 323

  Fly   398 LIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRPT 462
            |.|||..||..|||.|:|.||:..|.|||:.:||.:|...|.:..:|:::|.||.|.|::||:.:
Zfish   324 LFAIGLTNIMGSFVSAYPVTGSFGRTAVNSQTGVCSPAGGIITSVIVLLSLAFLMPLFFYIPKAS 388

  Fly   463 LAAIIISAVVFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAAR 527
            |||:||.||..|::.:|...:||.|:.||:|.:.||:... ..:::||..||.::...:||..||
Zfish   389 LAAVIICAVSPMVDFRVPLHIWRVKRLDLLPFLVTFLLSF-WEVQYGIAGGVLVSAFMLLYIMAR 452

  Fly   528 PKLSTELLTTQSGVEYSMITPDRCLIFPSVDYVRNLVNKQSIRQNVP--VVIDASHVYGADFTTA 590
            ||:.    .:..||  .::..|..|.|.|.:::..||.|.::..:.|  :|:|.|.:...|||..
Zfish   453 PKVK----VSDHGV--IVLEIDNGLNFTSTEHLSRLVYKHALHASPPRSLVLDCSQISSIDFTVI 511

  Fly   591 TVIDSLISDFNQRGQLLFFYNLKPSICSIFEHVSAAQFVVYYQEQQLDELLK 642
            ..:..|:..|..||..|.|..||||:..:   :..|....:.....:||.|:
Zfish   512 HELTDLLKQFQIRGAALIFTGLKPSVLQV---LLLADLPAFRHTDTVDEALQ 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	210/538 (39%)
		HCO3_cotransp	103..520	CDD:304903	172/424 (41%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	24/79 (30%)
slc26a11	NP_956061.1	sulP	16..541	CDD:273284	212/546 (39%)
slc26a11	NP_956061.1	STAS_SulP_like_sulfate_transporter	454..546	CDD:132913	28/100 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574464
Domainoid	1	1.000	46	1.000	Domainoid score	I12111
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm25858
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.740