DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and slc26a5

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_958881.1	Gene:	slc26a5 / 322846	ZFINID:	ZDB-GENE-030131-1566	Length:	739	Species:	Danio rerio

Alignment Length:	549	Identity:	155/549 - (28%)
Similarity:	264/549 - (48%)	Gaps:	87/549 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LPILGWLPKYNSQDAV-GDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSC 148
            ||||.|||.|..::.: ||:|:||:.|:..:||.||||.:|.:|..:|||:||....:|.|.|:.
Zfish    66 LPILTWLPSYPLKEYLFGDIVSGISTGVMQLPQGLAYAMLAAVPPVFGLYSSFYPVLLYTFFGTS 130

  Fly   149 KDVPMGPSAIVALL------------------TYQA------AQGSWQKSVLLCL--LSGIVELL 187
            |.:.:|..|:::|:                  |..:      |:.|.:..|::.|  |.||::.:
Zfish   131 KHISIGTFAVISLMIGGVAVREAPDSMFMVNGTNSSLVVNIEARDSRRVEVVVALTTLVGIIQFV 195

  Fly   188 MGLFGLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGI-TAKGN---TFVEIWTQVFHNIEHT 248
            :||...|||..:::.|:..|||:|.::.:..||::.:||: ||:.|   :.|.....|..||..|
Zfish   196 LGLLRFGFLAIYLTEPLVRGFTTAAAVHVSVSQLKYLLGVKTARFNGPLSVVYSLDAVLRNIADT 260

  Fly   249 RAGDTVLGLTCIVILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIMGY 313
            .....::||.|.|.|.:::.|:               :|...|:|  :......|:|:|...:.|
Zfish   261 NIVTLIIGLGCTVFLYIIKQLN---------------ERFKKKLL--IPIPGEIIVVIVSTGISY 308

  Fly   314 -MLHTEEHGAPFRVVGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLM 377
             ||.:|.:|..  |||:||.||...::|..|:..|                :.:..|.|.::...
Zfish   309 GMLMSENYGVD--VVGKIPTGLLPPKVPDFSVFPN----------------LFADAVPIAVVGFS 355

  Fly   378 ENIAICKAFA--NGKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYS 440
            ..|::.|.||  .|..||.:|||||:|..|..:||...|..|.::||..|..::|..|.::.:.:
Zfish   356 ITISLAKTFALKYGYSVDGNQELIALGLCNFVSSFFHTFVVTASMSRSLVQESTGGHTEIAGLLA 420

  Fly   441 GGLVMIALLFLTPYFYFIPRPT--LAAIIISAVVFMI-EVKVVKPMWRSKKSDLVPGVGTFVACL 502
            ..||::.::.:.  |.|.|.||  |||||:..::.|. :.:.:..:||..|.:|...:.:|.|.:
Zfish   421 SLLVLLVVVAIG--FVFQPLPTTVLAAIIMVNLLGMFKQTRDIPVLWRKSKIELAIWLVSFFASV 483

  Fly   503 VLPLEWGILIGVGLNVIFILYHAARPKLSTELLTTQSGVEYSMITPDRCLIFPSVDY--VRNLVN 565
            :|.|::|:.:.:...::.::|...|||          .|....| ||..|.|...:|  ......
Zfish   484 LLGLDYGLAVAMAFAILTVIYRTQRPK----------NVVLGQI-PDTGLYFDVDEYEEAEECSG 537

  Fly   566 KQSIRQNVPVVIDASHVYGADFTTATVID 594
            .:..:.|..:....|.:|.......|.||
Zfish   538 IKIFQSNSSIYFANSELYVKALKAKTGID 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	154/548 (28%)
		HCO3_cotransp	103..520	CDD:304903	128/452 (28%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	12/52 (23%)
slc26a5	NP_958881.1	sulP	67..722	CDD:273284	154/548 (28%)
		LrgB	259..>366	CDD:294396	33/141 (23%)
		STAS_SulP_like_sulfate_transporter	<643..719	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740