DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and Slc26a8

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_038954621.1	Gene:	Slc26a8 / 309646	RGDID:	1308898	Length:	1006	Species:	Rattus norvegicus

Alignment Length:	701	Identity:	149/701 - (21%)
Similarity:	266/701 - (37%)	Gaps:	215/701 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EDGKKVKPTVSTLD-----------CTRSWLQDCQRRTFNRKTLHKRL-------PILGWLPKYN 95
            ::.::..||...:|           |..||              ||.|       |.|.|:..|.
  Rat    35 QEHRRKGPTSGNMDINITTFKHHVQCRCSW--------------HKFLRCMLTVFPFLEWMCLYR 85

  Fly    96 SQD-AVGDLVAGITVGLTVIPQALAYAGIAG--LPVAYGLYASFVGCFVYIFLGSCKDVPMGPSA 157
            .:| .:|||:||::|||..:||.|..:.:..  :|.....||:|....:|:..|||..:.:||..
  Rat    86 FKDWLLGDLLAGLSVGLVQVPQGLTLSLLTRQLIPPLNVAYAAFCSSVIYVIFGSCHQMSIGPFF 150

  Fly   158 IVALLTYQAAQ-----------GSWQKS------------------VLLCLLSGIVELLMGLFGL 193
            :|:.|.....:           |::.|.                  .....|:||::|.||:.|:
  Rat   151 LVSALMINVLKERPFNNGHLIMGTFVKDDFSVPTFYLNYNRSLSMVASTTFLTGIIQLSMGMLGM 215

  Fly   194 GFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGITAK--GNTFVEIWTQVFHNIEHTRAGDT--V 254
            ||:..::....:|.:.:||:|.|:.:|:..:.||...  ......|:..:.:.|...:|..|  :
  Rat   216 GFVATYLPEAATSAYLAAVALHIILAQMTCIFGIMVSFHAGPIAFIYNIINYCIALPKANSTSIL 280

  Fly   255 LGLTCIVILLLMRSLSSCRIG--------PVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIM 311
            |.||.:|.|.:.:.:   ||.        |::......|....::|  .:.|..:.:|:.:....
  Rat   281 LFLTAVVALRVNKCI---RISFNRYPIEFPMELLLILGFSMLTSRI--TMATENSKMLINMIPYS 340

  Fly   312 GYMLHTEEHGAPFRVVGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISL 376
            .....|.|.|...|:|      |.::.|            .|...|:              ||||
  Rat   341 FVFPETPEFGILSRIV------LQALSL------------SVVSSFL--------------LISL 373

  Fly   377 MENIAICKAFANGKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVR--------- 432
            .:.||....:.    .:::|:|||||..|:.:||.:....||.::|..:.:.||.|
  Rat   374 GKKIANLHNYR----TNSNQDLIAIGLCNLVSSFFRCCVFTGGMARTIIQDKSGGRQQKKLACFS 434

  Fly   433 -----------------------TP-LSNIYSGGLVMIALLFLTPYFYFIPRPTLAAIIISAVVF 473
                                   :| .:::...|::::.::.:..:|..:|...||.||:|.||.
  Rat   435 ANRRPQLQTGTNACLTRSLQPALSPQFASLVGAGVMLLLMVKIGSFFDNLPNAVLAGIILSNVVP 499

  Fly   474 MIEVKVVKP-MWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAARPKLSTELLTT 537
            .:|.....| :||..:.:.|..:.||.|.:.|.|:.|:||.:......|...:.|.|:   |:..
  Rat   500 YLETIYNLPTLWRQDQYECVVWMVTFSAAIFLGLDVGLLISLVFTFFVITVRSHRTKI---LVLG 561

  Fly   538 QSGVEYSMITPDRCLIFPSVDYVRNLVNKQSIRQNVPVVIDASHVYGADFTTATVIDSLISDFNQ 602
            |               .|:.:..||:                                     |:
  Rat   562 Q---------------IPNTNIYRNV-------------------------------------NE 574

  Fly   603 RGQLLFFYNLKPSICSIFEHVSAAQFV-VYYQEQQLDELLKERNYVQKRLE 652
            ..:::....:|     |.:..|:..|| ||:.:.   :||||.|.|:..|:
  Rat   575 YREVILIPGVK-----ILQCCSSITFVNVYHLKH---KLLKEVNMVKLPLK 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	127/606 (21%)
		HCO3_cotransp	103..520	CDD:304903	110/493 (22%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	6/77 (8%)
Slc26a8	XP_038954621.1	Sulfate_transp	90..524	CDD:395733	104/474 (22%)
Slc26a8	XP_038954621.1	STAS_SulP_like_sulfate_transporter	<730..805	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920