DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and Slc26a6

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001137289.1	Gene:	Slc26a6 / 301010	RGDID:	1310197	Length:	758	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	142/587 - (24%)
Similarity:	266/587 - (45%)	Gaps:	113/587 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RSWLQDCQRRTFNRKTLHKRLPILGWLPKYNSQD-AVGDLVAGITVGLTVIPQALAYAGIAGLPV 128
            |:|.:..:.|.  :..|.:.:|:|||||:|..:: .:|||::|::|.:..:||.||||.:||||.
  Rat    59 RTWFRCSRARA--KSLLIQHVPVLGWLPRYPVREWLLGDLLSGLSVAIMQLPQGLAYALLAGLPP 121

  Fly   129 AYGLYASFVGCFVYIFLGSCKDVPMGPSAIVALL--------------------TYQAAQGSWQK 173
            .:|||:||...|||...|:.:.:.:|..|:::::                    |...|:  .|.
  Rat   122 MFGLYSSFYPVFVYFLFGTSRHISVGTFAVMSVMVGGVTESLTADEAFVQSLNTTVDGAR--VQV 184

  Fly   174 SVLLCLLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGITAKGN------ 232
            :..|..|.|:.::.:||...||::.::|.|:...:|:|.|:.:|.||::.|.||....:
  Rat   185 AYTLSFLVGLFQVGLGLVHFGFVVTYLSEPLVRSYTTAASVQVLVSQLKYVFGIKLNSHSGPLSV 249

  Fly   233 --TFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWI 295
              |.:|:..|:...:..|.....|.|:..:::.||...|......|:.           .::|.:
  Rat   250 IYTVLEVCAQLPKTVPGTVVTAIVAGVVLVLVKLLNEKLRRRLPLPIP-----------GELLTL 303

  Fly   296 VGTARNAILVVVCCIMGYMLHTEEHGAPFR--VVGEIPPGLPSIQLPPTSLTANETSNGVAEGFV 358
            :|..          .:.|.:...:.   |:  |||.|..||.....|.|.|.|....|..|
  Rat   304 IGAT----------AISYGVKLNDR---FKVDVVGNITTGLIPPVAPKTELFATLVGNAFA---- 351

  Fly   359 EMVHSMGSGLVVIPLISLMENIAICKAFA--NGKPVDASQELIAIGTANIFNSFVQAFPGTGALS 421
                        |.::.....|::.|.||  :|..||::|||:|:|.:|:...|.|.||.:.::|
  Rat   352 ------------IAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGFFQCFPVSCSMS 404

  Fly   422 RGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRPTLAAIIISAVVFMI-EVKVVKPMWR 485
            |..|..::|..|.::...|...:::.::.|...|..:|:..|||:||..:..|: :...:..:|:
  Rat   405 RSLVQESTGGNTQIAGAVSSLFILLIIVKLGELFRDLPKAVLAAVIIVNLKGMMKQFSDICSLWK 469

  Fly   486 SKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAARPKLSTELLTTQSGVEYSMITPDR 550
            :.:.||:..:.||||.::|.|:.|:.:.:..:::.::.....|             .||::..
  Rat   470 ANRVDLLIWLVTFVATILLNLDIGLAVSIVFSLLLVVIRMQLP-------------HYSVLGQ-- 519

  Fly   551 CLIFPSVDYVRNLVNKQSIRQ--NVPVVIDASHVYGADFTTATV------------IDSLISDFN 601
               .|..|..|::......::  .|.|...::.:|   |..|.:            :|.||:...
  Rat   520 ---VPDTDIYRDVAEYSGAKEVPGVKVFRSSATMY---FANAELYSDSLKKKCGVDVDRLITQKK 578

  Fly   602 QR 603
            :|
  Rat   579 KR 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	138/566 (24%)
		HCO3_cotransp	103..520	CDD:304903	114/449 (25%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	12/73 (16%)
Slc26a6	NP_001137289.1	sulP	78..737	CDD:273284	138/566 (24%)
		HCO3_cotransp	<369..452	CDD:304903	26/82 (32%)
		STAS_SulP_like_sulfate_transporter	<653..734	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710