Protein Alignment Esp and Slc26a4

DIOPT Version :10

• Sequence 1: NP_524490.2
• Gene: Esp / 42962
• FlyBaseID: FBgn0013953
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_062087.1
• Gene: Slc26a4 / 29440
• RGDID: 3293
• Length: 780
• Species: Rattus norvegicus
• Alignment Length: 642
• Identity: 166/642 - (25%)
• Similarity: 286/642 - (44%)
• Gaps: 158/642 - (24%)

  Fly    55 KPTVSTLDCTRSWLQDCQRRTFNRKTL-----------HKR--------LPILGWLPKYNSQD-A 99
            :|..|.|    ::.|..:||...|:||           .||        ||||.|||||..:: .
  Rat    24 RPVYSEL----AFQQQRERRLPERRTLRDSLARSCSCSRKRAFGALKALLPILDWLPKYRVKEWL 84

  Fly   100 VGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKDVPMGPSAIVALL-- 162
            :.|:::|::.||....|.:|||.:|.:||.||||::|.....|...|:.:.:.:||..:|:|:
  Rat    85 LSDIISGVSTGLVGTLQGMAYALLAAVPVQYGLYSAFFPILTYFVFGTSRHISVGPFPVVSLMVG 149

  Fly   163 ------------------------------TYQAAQGSWQKSVLLC----LLSGIVELLMGLFGL 193
                                          |..||:      |||.    ||.||::|:.|...:
  Rat   150 SVVLSMAPDDHFLVPSGNGSTLNTTTLDTGTRDAAR------VLLASTLTLLVGIIQLVFGGLQI 208

  Fly   194 GFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGITAKGNTFV--EIWT--QVFHNIEHTRAGDTV 254
            ||::.:::.|:..|||:|.:..:|.||::.||.::.|....|  .|:|  ::|.||..|...|.:
  Rat   209 GFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLIEIFQNIGDTNIADFI 273

  Fly   255 LGLTCIVILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIMGYMLHTEE 319
            .||..|::.:.::.|:               .|..:||  .|......|:.::...:.|..:.|.
  Rat   274 AGLLTIIVCMAVKELN---------------DRFKHKI--PVPIPIEVIVTIIATAISYGANLEA 321

  Fly   320 H-------GAPFRVVGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLM 377
            :       ..|   .|.:||.|||:.|                 |.:|:.:..|..||...|:
  Rat   322 NYNAGIVKSIP---SGFLPPVLPSVGL-----------------FSDMLAASFSIAVVAYAIA-- 364

  Fly   378 ENIAICKAFANGKP--VDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYS 440
              :::.|.:|....  :|.:||.||.|.:|:|:.|...|..|.||||.||..::|.:|.::.:.|
  Rat   365 --VSVGKVYATKHDYIIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQESTGGKTQVAGLIS 427

  Fly   441 GGLVMIALLFLTPYFYFIPRPTLAAIIISAV--VFMIEVKVVKPMWRSKKSDLVPGVGTFVACLV 503
            ..:||:|::.|......:.:..|||::|:.:  :|| :|..|..:|:..|:|.|..|.|.:..::
  Rat   428 AVIVMVAIVALGKLLEPLQKSVLAAVVIANLKGMFM-QVCDVPRLWKQNKTDAVIWVFTCIMSII 491

  Fly   504 LPLEWGILIGVGLNVIFILYHAARPKLSTELLTTQSGVEYSMITPDRCLIFPSVDYVRNLVNKQS 568
            |.|:.|:|.|:...::.::.....|        :.:|:. |:.:.|   |:.|:.:.:||...:.
  Rat   492 LGLDLGLLAGLLFGLLTVVLRVQFP--------SWNGLG-SVPSTD---IYKSITHYKNLEEPEG 544

  Fly   569 IR----------QNV---------PVVIDASHVYGADFTTATVIDSLISDFNQRGQL 606
            ::          .||         .|..||..||.........|..||    ::|||
  Rat   545 VKILRFSSPIFYGNVDGFKKCVKSTVGFDAIRVYNKRLKALRRIQKLI----KKGQL 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_524490.2	SUL1	93..622	CDD:440424	148/585 (25%)
Slc26a4	NP_062087.1	PRK11660	70..725	CDD:481320	154/592 (26%)