DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and SPBC3H7.02

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_595773.1	Gene:	SPBC3H7.02 / 2540681	PomBaseID:	SPBC3H7.02	Length:	877	Species:	Schizosaccharomyces pombe

Alignment Length:	587	Identity:	176/587 - (29%)
Similarity:	289/587 - (49%)	Gaps:	87/587 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 STNLTEPNGSSNSVGSQGSKEFILTEDGKKVKPTVSTLDCTRSWLQDCQRRTFNRKTLH---KRL 85
            ::.||:...||.|:.:..:.:..:   |:.|:|    |.....||:......|..:.||   ...
pombe    63 ASKLTKHGDSSQSLSTLPNNDISV---GEYVEP----LPSVPGWLKQNIFSHFGTRLLHYLRSLF 120

  Fly    86 PILGWLPKYNSQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKD 150
            ||:.|||:||....|.|.:||||||..|:||.::||.:|.||..||||:||||..:|....:.||
pombe   121 PIMNWLPRYNWNWLVYDFIAGITVGCVVVPQGMSYAKVATLPAQYGLYSSFVGVAIYCIFATSKD 185

  Fly   151 VPMGPSAIVALLT-------------YQAAQGSWQKSVLLCLLSGIVELLMGLFGLGFLIDFVSG 202
            |.:||.|:::|:|             |.||    |....|.||:|.:...:||..|||:|:|:..
pombe   186 VSIGPVAVMSLVTSKVIANVQAKDPNYDAA----QIGTTLALLAGAITCGLGLLRLGFIIEFIPV 246

  Fly   203 PVSSGFTSAVSLIILTSQIQSVLGITAKGNT---FVEIWTQVFHNIEHTRAGDTVLGLTCIVILL 264
            |..:|||:..:|.|:..|:.|::|..::.:|   ...:..|...|:.||:. |...||..:.||.
pombe   247 PAVAGFTTGSALNIMAGQVSSLMGYKSRVHTNAATYRVIIQTLQNLPHTKV-DAAFGLVSLFILY 310

  Fly   265 LMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIMGYML--HTEEHGAPFRVV 327
            |:|......|     |..:.|||    :.::....|:|::::|...:.|.:  |..|: .|..::
pombe   311 LVRYTCQHLI-----KRYTKFQR----VFFLTNVLRSAVIIIVGTAISYGVCKHRREN-PPISIL 365

  Fly   328 GEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAF--ANGK 390
            |.:|.|...:.:|..|.              ::...:.|.|.|..::.|:|:|:|.|:|  .|..
pombe   366 GTVPSGFRDMGVPVISR--------------KLCADLASELPVSVIVLLLEHISIAKSFGRVNDY 416

  Fly   391 PVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYF 455
            .|...|||||:|..|:...|..|:|.||:.||.|:|..|||||||..|::.|:|::||..||..|
pombe   417 KVIPDQELIAMGATNLIGVFFHAYPATGSFSRSAINAKSGVRTPLGGIFTAGVVVLALYCLTGAF 481

  Fly   456 YFIPRPTLAAIIISAVV-FMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVI 519
            |:||...|:|:||.:|. .:|..:.....||.:..:.:..:......:...:|.||...|.|:..
pombe   482 YYIPNAVLSAVIIHSVFDLIIPWRQTLLFWRMQPLEALIFICAVFVSVFSSIENGIYTAVCLSAA 546

  Fly   520 FILYHAARP--------KLSTELLTTQSGVEYSMITPDRCLIFPSVDYVRNL---VNKQSIRQNV 573
            .:|:..|:|        |::.:....::                |:|.||::   :|::.:..|:
pombe   547 LLLFRIAKPSGSFLGILKIANKFDDDEN----------------SIDVVRDIYVPLNQKGMNPNL 595

  Fly   574 PV 575
            .|
pombe   596 TV 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	162/522 (31%)
		HCO3_cotransp	103..520	CDD:304903	142/437 (32%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	7/34 (21%)
SPBC3H7.02	NP_595773.1	SUL1	114..720	CDD:223732	163/529 (31%)
SPBC3H7.02	NP_595773.1	STAS_SulP_like_sulfate_transporter	597..729	CDD:132913	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	213	1.000	Domainoid score	I589
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I801
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		mtm9288
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
TreeFam	0	0.000	Not matched by this tool.
	11	10.890